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pfam07458: SPAN-X 
Sperm protein associated with nucleus, mapped to X chromosome
This family contains human sperm proteins associated with the nucleus and mapped to the X chromosome (SPAN-X) (approximately 100 residues long). SPAN-X proteins are cancer-testis antigens (CTAs), and thus represent potential targets for cancer immunotherapy because they are widely distributed in tumors but not in normal tissues, except testes. They are highly insoluble, acidic, and polymorphic.
Links
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Statistics
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PSSM-Id: 148837
View PSSM: pfam07458
Aligned: 9 rows
Threshold Bit Score: 120.343
Threshold Setting Gi: 75044179
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:

pfam07458 is a member of the superfamily cl06478.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75044176   1 MGQ-QCSAGGVKRSVPCDSNE-AGETMPETPSGDSDPQPAPKKLKTSDSST-IVVVRHRRKVKRrysVSDELVNDHSRGN 77
gi 75044163   1 MEQpTSSTNGEKRKSPCESNNnKNDEMQETPNRDLAPKQSLKKTKTSEYPT-LLMFPYKKFKKI---SSSQVENYQSPGN 76
gi 74743051   1 MEQpTSSTNGEKTKSPCESNNkKNDEMQEVPNRVLAPEQSLKKTKTSEYPI-IFVYYLRKGKKI---NSNQLENEQSQEN 76
gi 74743052   1 MEQpTSSTNGEKRKSPCESNNkKNDEMQEAPNRVLAPKQSLQKTKTIEYLT-IIVYYYRKHTKI---NSNQLEKDQSREN 76
gi 77416663   1 MDK-QSSAGGVKRSVPCDSNE-ANEMMPETPTGDSDPQPAPKKMKTSESST-ILVVRYRRNFKRt--SPEELLNDHAREN 75
gi 75044179   1 MDE-KSRAGGVKRSAPCDSNE-ANEAMPETQSGDSHPQPAPKKLKTSESST-TIVLSYRRNVKIt--SAQELVNDHAREN 75
gi 75044177   1 MGQ-QSSAGGVKRSTPCESNE-VNETMPETSRGDSQPEPAPKKSKASDSST-VLVLCYRREVRRrysVSDELVNDHSREN 77
gi 75044172   1 MEKpTSSTNGEKRKSPCDSNN-RNDEMQETPNRDLVTEPSLKKMKTSEYSTvVLVLCCRETKKI---HSNQLENDQSQEN 76
gi 75044171   1 MEKpTSSTNGEKRKSPCDSNN-RNDEMQETPNRDLALEPSLKKMKTSEYST-VLVLCYRKTKKI---HSNQLENDQSQEN 75
                        90       100
                ....*....|....*....|..
gi 75044176  78 GINPLQMEEKEFMEIRVETPAK 99
gi 75044163  77 TIYPIQEEEEDLDSFEGSSQEG 98
gi 74743051  77 SINPIQKEEDEGVDLSEGSSNE 98
gi 74743052  77 SINPVQEEEDEGLDSAEGSSQE 98
gi 77416663  76 RINPLQMEEEEFMEIMVEIPAK 97
gi 75044179  76 RINTLQMEEEEFIEITTEIPEK 97
gi 75044177  78 RINRLQIDEEEFTQISVETAAN 99
gi 75044172  77 SINPVQEEEDEDLDSSAESSKQ 98
gi 75044171  76 SVNPVQEEEDEGSSQEDEDLDS 97
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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