Conserved Protein Domain Family
DGCR6
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pfam07324: DGCR6 (this model, PSSM-Id:148752 is obsolete and has been replaced by 462145)
DiGeorge syndrome critical region 6 (DGCR6) protein
This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.
Links
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Statistics
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PSSM-Id: 148752
Aligned: 8 rows
Threshold Bit Score: 233.966
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
O73770         1 MERFGGAGYEv-------aAAELSRQ-----Q-------ERHYRLLSELQELVKALPSSCQQRLSYTTLSDLALALLDGT 61  chicken
Q640G2         1 MAGYLGMYEE---------TRDITQQ-----Q-------ERHYYLLSELQSLVKDLPSACHQRMSHTILSDLALALIDGT 59  African clawed ...
Q4T1V1         1 MERYPGAVSG-----------DSTKQ-----Q-------ERHYYLLSELQALVKDLPSSFQQRLSYSTLGDLALALIDGT 57  spotted green p...
Q6TH21         1 MDLY-CTVSGd--------QSDSARQ-----Q-------ERHYYLLSELQTLVKDLSSSFQQRLSYTTLSDLAQALIDGT 59  zebrafish
Q17NK5       268 SQDSQAESQEstt---dlaLVEEPYQsqeflQ-------RKLYFLLEQLKKMHATLPEQFQLRISYELLAGLANSLLNDT 337 yellow fever mo...
O35347         1 MDRYAAAGDE---------AADRARQ-----Q-------ERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGT 59  house mouse
XP_001353153   1 MTDITVSNEGptngsepvaVAEDPFQ-----QpspeflqRKIYFLVDQLRTMHAELPENLQTRISYDLLTELANCVLNDS 75  Drosophila pseu...
XP_001638724   1 M---------------------------------------------SDVQCSSSFLHSKYKGKFTYDVLADVATSLLDGT 35  starlet sea ane...

O73770        62 VFEIVQGLLEIQHLTEKNLYSQRLKLHSEHRGLKQELFHRHKEAQQ--CCRPHNLPLLRAAQQREMEAVEQRIREEQRMM 139 chicken
Q640G2        60 VFEIVQGLLEIQHLTEKNLYNQRLKLHAEHRALKQDLLRKHREAQQ--SCKTHNFSVLKATQQKELESLEQRIKEEQRMM 137 African clawed ...
Q4T1V1        58 VYEIVQGLLDIQHLTEKNLYNQRQKLHCEHQALKQELTKKHKDALQ--TCKSHNLALLKTNQQAEVEALEIRVREEQRMM 135 spotted green p...
Q6TH21        60 VYEIVQGLLDIQHLTEKNLYNQRQKLHSEHRGLKQDLIRKHKQALQ--ACKSHNLSVLKTNQRAETEALDQRVKDEQRMM 137 zebrafish
Q17NK5       338 IFEIVKGLMEIQHVTEKHLMQVREKVENDHQLEVKQWESKIQDPEE----LEHIIALMKIKHSKNMKE-----------T 402 yellow fever mo...
O35347        60 VFEIVQGLLEIQHLTEKSLYNQRLRLQNEHRVLRQTLRQKHLEAQQ--SCRPHNLPVLQAAQQRELEAMEHRIREEQQAM 137 house mouse
XP_001353153  76 IFVIVKALMELQHETERHLIKMRMQVENEYEIEVSDWRAKIKDPEE----LLHILGLMKLKHSKKLVE-----------S 140 Drosophila pseu...
XP_001638724  36 VFEIVKGLEDIQQLTERNLLNKRMKVINSHKVQRMEQAKKHKEEIEknQHRPHHIPIVEKTNEEDKEKLEQRLETEITSM 115 starlet sea ane...

O73770       140 DEKIVLELDQKVIDQQSTLEKAGVSGFYITTNPQELTLQMNLLELIRKLQQKESESEK 197 chicken
Q640G2       138 DEKIVLELDQKVIDQQSTLEKAGVSSFYITKNPQELMLQMNILELIQKLQQKESLSSK 195 African clawed frog
Q4T1V1       136 DKKIVAEMDQKVVDQQNTLEKAGVPGFYITTNPQELTMQMNLLELILKLQQ------K 187 spotted green pufferfish
Q6TH21       138 DEKIVAEMDQKVLDQQNTLEKAGVPGFYITSNPQEVMMQMNLLELVLKLQQKETLSGS 195 zebrafish
Q17NK5       403 DMKLVLHLDQKVKDQQSTLEKAGVPGFYVSDNPMEIKIQMYLLDFILRLSRLKFEPNK 460 yellow fever mosquito
O35347       138 DRKIVLELDRKVADQQSTLEKAGVAGFYVTTNPQELTLQMNLLELIRKLQQRSCQVGK 195 house mouse
XP_001353153 141 DKKIIEILDQKVNDQQSTLQKAGVPGFYVTENPKEIKIQMFLLDFILRLSRLNYEPNK 198 Drosophila pseudoobscura pseudoobscura
XP_001638724 116 DQKLVLELDQIVCDQQATLERAGVPLFFVTNNPDDVRLQMYLLEFIQQL-----IPGP 168 starlet sea anemone
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