Conserved Protein Domain Family
DAP10
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pfam07213: DAP10 (this model, PSSM-Id:148675 is obsolete and has been replaced by 284598)
DAP10 membrane protein
This family consists of several mammalian DAP10 membrane proteins. In activated mouse natural killer (NK) cells, the NKG2D receptor associates with two intracellular adaptors, DAP10 and DAP12, which trigger phosphatidyl inositol 3 kinase (PI3K) and Syk family protein tyrosine kinases, respectively. It has been suggested that the DAP10-PI3K pathway is sufficient to initiate NKG2D-mediated killing of target cells.
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Statistics
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PSSM-Id: 148675
Aligned: 3 rows
Threshold Bit Score: 116.569
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6X9T8  1 MAPPGHLLFLFLLPVAASQTNEGSCSGCGPLSLPLLAGLVAADAVMSLLIVGVVFVCMRLHSRPAQeDGRVYINMPGRG 79  Norway rat
Q70RD5  1 MIHPGHILFLLLLPVAAAQTTPGSCSGCGSLSLPLLAGLVAADAVASLLIVGAVFLCARPRRSPAQ-DGKVYINMPGRG 78  crab-eating macaque
Q1XF11  1 MVPPGNILFLLLLPVATAQMTPGSCSGCGPLSLPLLAGLVAADAVVSLLIVVVVFVCARLRSRPTQeDDKIYINMPGRG 79  cattle
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