3B4W


Conserved Protein Domain Family
ALDH_CddD-AldA-like
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cd07089: ALDH_CddD-AldA-like 
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Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins
The 6-oxolauric acid dehydrogenase (CddD) from Rhodococcus ruber SC1 which converts 6-oxolauric acid to dodecanedioic acid; and the aldehyde dehydrogenase (locus SSP0762) from Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305 and also, the Mycobacterium tuberculosis H37Rv ALDH AldA (locus Rv0768) sequence; and other similar sequences, are included in this CD.
Links
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Statistics
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PSSM-Id: 143408
Aligned: 23 rows
Threshold Bit Score: 558.397
Created: 12-Dec-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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NAD bindingcatalytic
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:NAD binding site [chemical binding site]
Evidence:
  • Structure:3B4W: Mycobacterium tuberculosis aldehyde dehydrogenase complexed with NAD+, defined using 3.5 A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3B4W_A        28 VRCPATGEYVGKVPMaaaaDVDAAVAAARAAFDNgpwpstPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQpptiIET 107 Mycobacterium t...
NP_737165     42 VVDPATGQEWGSVPEagqvELDHAVGAAREALPGwg--slTAADRAEYLVRIAEEIEKRAEVLALTNTRENGSpi-sETR 118 Corynebacterium...
YP_001508870  25 VLNPATEEVIGAVPDgtvsDVDRAVAAARRAFDEgpwptlSANERATALLRMADVMERRVDELKELSVREAGStralADT 104 Frankia sp. EAN...
YP_714390     24 AINPATEQPLGVVPQasaeDVTRAIMAAREAFDDgpwpgmKPSERSRVLMRMAEVMRRRQAELVDLDVAEVGRarmlAES 103 Frankia alni AC...
YP_615953     25 VINPADESLLIEAPVgsarQVEAAIGAARHAFDRsdwshlPVAERQKILTRFLDALDARKGAIVDMIVAEAGAtrmlAEF 104 Sphingopyxis al...
ZP_01301841   27 IINPATEAVIGHAPVgnaaAVDAAIAAARDAFDTgiwprmAMSERATCLRRMHAALDARRQQIAALIIAEVGCsqgiTQG 106 Sphingomonas sp...
YP_002087356  26 ILNPASEAVIGQAPVgdlaSAEAAICAARAAFDHgpwpllGMAERAACMRRLHAALVARRERIVALIVAEVGCsqgvTQA 105 Pseudomonas aer...
YP_289348     37 VYNPATEEVIATVSGatkeQVDEAIRAARTAFDTws--kmSGEERSAAMHSLADRLEARWEELLASIVNEVGTpvstAEF 114 Thermobifida fu...
AAL14238      26 VLNPATEEVIGTVPDgtaaDVDAAVAAARAAFDGwa--stPVDKRAQYLRAIAAGIADRSDELARTISAEMGAplsfAQA 103 Rhodococcus ruber
NP_961517     29 DLSPSTEAVIATAPDasvaQVDDAIAAARRAFDSgpwgrmSAEQRARCLNQLGEALTKHADDFFALSQTEWGCig-nERI 107 Mycobacterium a...

Feature 1                                                                    #####               
3B4W_A       108 MHWMGSMGAMNYFAGAadk----vtwTETRTgs-----------yGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALL 172 Mycobacterium t...
NP_737165    119 GAAANAAGIFRYFATLapf----lddPDIRPfpa---------ggAESLVDKDPIGVCALIAPWNFPINLVVIKLAPALL 185 Corynebacterium...
YP_001508870 105 LQVSVPLHHFRDMAERvl-------rQFPFEramlpt---vgptlAQGVVRREPYGVAALISAYNFPLFLNILKLAPALA 174 Frankia sp. EAN...
YP_714390    104 VFVDVPIEHFEDMAERvl-------lSFEFDepmlpy--etplgvGQGVVRREPYGVASIITPYNAPFFLAAFKLAPALA 174 Frankia alni AC...
YP_615953    105 LQYGIPMKHARRTVELasrpa-vtplPVELTpnaqg-----rttlGTGVVSREPVGVVAAISPYNFPFFLNVGKVVPALA 178 Sphingopyxis al...
ZP_01301841  107 MQVANPLDHLLAAVEHstrdd-svrlPIDITpdpfnp--dgpkkiGGTTVVREPVGVVAAITGYNFPFLINLAKIVPALL 183 Sphingomonas sp...
YP_002087356 106 MQVDMPLAHVLTAIEQslss--learPISVSmqpdpmnpqgphllGSGSIEREPVGVVAGITGYNFPFLLNLAKVFPALL 183 Pseudomonas aer...
YP_289348    115 LQVKMGLGHLRWFADAakkdrtvhlgPYDVPv------------pTMSDVDHYPVGVVAAITGYNYPLNLAGFKYGAALA 182 Thermobifida fu...
AAL14238     104 MQVPLPINSFSHAAAVa--------eSFPFErt-----------eGSSVIVREPIGVVGAITPWNYPLHQIAAKVAYALA 164 Rhodococcus ruber
NP_961517    108 MQIDGAGFMSLHAAQLatql---vdqEVAGIs------------aGTTLLRHVPLGVVAVLTPWNFPHCLNVMKLNHALA 172 Mycobacterium a...

Feature 1               #                                     #             ####  #  #           
3B4W_A       173 AGCTIVLKPAAetPLTANALAEVFAe-vGLPEGVLSVVPGGIe-tGQALTSNPdIDMFTFTGSSAVGREVGRRAAemLKP 250 Mycobacterium t...
NP_737165    186 AGCSVVIKPASptPLSIRFIIEAVEa-aGVPAGVINLLTGSGr-fGDAMVRHPgVNKVAFTGSTPVGRKIASACGelLRP 263 Corynebacterium...
YP_001508870 175 AGCTVVLKPAPttPLEAFVLGEMADe-aGLPPGVLNIVSGGIa-aGEALTTHPgVDIVSFTGSDTVGRLVYTQAAqsLKK 252 Frankia sp. EAN...
YP_714390    175 AGCTTVLMPSPhtPLSAFLVAEIAEe-aGLPPGVFNVVTGTPa-aGELLTSHPaVDIVSFTGSDTVGRKIVKQAAdtLKK 252 Frankia alni AC...
YP_615953    179 VGCTVVLKPSPytPMEALILGEIADe-vGLPKGVLSIVTGDIe-tGKLLTTDPrVDLVHFTGSDKVGAMIQAQAAptLKR 256 Sphingopyxis al...
ZP_01301841  184 AGNTMVLKPSPftPFSALLFGEIAEe-iGLPKGVLNIVTGGPe-vGTTLTCDPrVDLVTFTGSEGVGAAIMAQAAptLKR 261 Sphingomonas sp...
YP_002087356 184 AGNTLVLKPSPftPYSALLFGEVAEe-aGLPRGVLNIVTGGAe-vGTLLSSDPrVDMVSFTGSEAVGISIMSQAAatLKR 261 Pseudomonas aer...
YP_289348    183 AGCTVVLLPSPrtPLTTLLLGEIIRe-sDLPDGVINVVLGGAd-iGQYLSSHPgVDKVSFTGSDAVGAKIMEQAAanLND 260 Thermobifida fu...
AAL14238     165 AGNTIVVKPSEvaPLNAWMLAEIIDa-aGVPAGVFNLVSGTGpvvGEALASHHeVDMISFTGSTNAGKRVSELAAqtVKR 243 Rhodococcus ruber
NP_961517    173 AGNTVVLKPSPltPLAGLALARLIDehtDIPPGVVNVVTPSGveaAKLLTTDPrIDMVSFTGSSAVGRQVMSAAGdtIKR 252 Mycobacterium a...

Feature 1           ###                                  #                                       
3B4W_A       251 CTLELGGKSAAIILEDv---DLAAAIPMMVFSGVMNaGQGCVNQTRILAPrsrYDEIVAAVTNFVTALpvgppsdpaaQI 327 Mycobacterium t...
NP_737165    264 VTLELGGKSSAIVLPDa---DMSVLSARLIRSCMRNtGQTCYISTRIIAPasrYEEVVQVVADTIAAGrqgdpldedtIF 340 Corynebacterium...
YP_001508870 253 VVLELGGKSANIITADv---DLDLVVPTIVNGMTTHaGQGCSLLTRTLVHrsrLDELVGLVKQSLDHItvgdpadpatTM 329 Frankia sp. EAN...
YP_714390    253 VVLELGGKSANIVCEDa---DLTKVIPDVVMNFTVNcGQGCSMLTRTLVHesiHDDLVAGLKKAMDHVrigdpadptvTM 329 Frankia alni AC...
YP_615953    257 IVMELGGKSALIVRSDa---DIQKAAAAGLMGFTTHcGQGCALTTRHLVHnsvRPQFVEALKGMLTHIrignpadpavNY 333 Sphingopyxis al...
ZP_01301841  262 VHLELGGKSALIVRQDa---DIARAAGMAVGVLSVNaGQGCALLTRLVVHnsiRKAFVETACAIASQFkigdpadptvAM 338 Sphingomonas sp...
YP_002087356 262 VHLELGGKSPLIVRADa---DVQAAAFAAVAGLTVNaGQGCALLTRFLVHnslRAAFVQCAKAIASQWkigdpadpsvLM 338 Pseudomonas aer...
YP_289348    261 VVLELGGKSANIVLPGc---DVESFAVDMHMRWSRNsGQGCAALARLLVHedlFDRFMKAGAEAFPKMkvgdpwdpetHI 337 Thermobifida fu...
AAL14238     244 VALELGGKSANIVLDDa---DIDELMPNAVQWAMINsGQTCSALTRLLVPraiLTEAETAAKTIAEAYtvgapddpdtTL 320 Rhodococcus ruber
NP_961517    253 ILLELGGKSASIVLDDanvtDEMLEQMLFQSCSLHA-GQACILHSRLLLPdslHDDVVDRLAALAREVkvgdptdpdvQM 331 Mycobacterium a...

Feature 1                                                                       # #              
3B4W_A       328 GPLISEKQRTRVEGYIAKgieeGARLVCGGGRpeg----ldnGFFIQPTVFADvdnkmTIAQEEIFGPVLAIIPYDt--- 400 Mycobacterium t...
NP_737165    341 GPVATASQYATVMEYIESghaeGARAVTGGAAtagltgglenGVFIEPTVFADvtpdmRIAAEEIFGPVISILRYDdsag 420 Corynebacterium...
YP_001508870 330 GPLISAAQRAKVESLISAgraeGAQVAYGGGRpah----ldkGFFVEPTLFVDvdnsmTVARKEFFGPVGVVIAFDd--- 402 Frankia sp. EAN...
YP_714390    330 GPLISAAQRDKVETLIRAgldeGAQLAYGGGRpth----lpkGFFVEPTVFVGvensmTIAQREFFGPVTVVIPFRd--- 402 Frankia alni AC...
YP_615953    334 GPLIREVARKRTEDYVAIardeGATLVSGGKRpeg----ldkGFYFEPTLFDNvkndsRLAQEEVFGPIGAVIGFDd--- 406 Sphingopyxis al...
ZP_01301841  339 GPLIRESQREKVERLITIgrdeGARIVHGGGRpag----ldkGFFTDITIFDDvdnkmTIAQEEVFGPVDCVIGFDt--- 411 Sphingomonas sp...
YP_002087356 339 GPLIRESQRARVEHFIASgrdaGATLVCGGGRpag----ldqGFFSEITLFDDvrndmAIAQEEIFGPVGVTIGFDt--- 411 Pseudomonas aer...
YP_289348    338 GPLIRPDHRDRVNGFITEaleqGGKALLQVETplp-----ekGWYVNPILLGNlphsaRAVQQEIFGPVAVVLTYKd--- 409 Thermobifida fu...
AAL14238     321 GPLVSATQLKRVRGYIDRgvqeGATLITGGSEpveg---lavGYYVKPTIFSEvtpdmTIHREEIFGPVLSIAPYDt--- 394 Rhodococcus ruber
NP_961517    332 GPLISAAQRDRVEAHIAGarsdGATLVTGGGRpag----ldvGYYVEPTILSGvepnsTIAQEEVFGPVLSVLRYRd--- 404 Mycobacterium a...

Feature 1                                                             #                          
3B4W_A       401 EEDAIAIANDSVYGLAGSVWTTdVPKGIKISQqIRTGTYGINWYa--FDPGSPFGGYKNSGIGRENG-PEGVEHFTQQKS 477 Mycobacterium t...
NP_737165    421 VEEAIAIANNTEFGLGGLVFGAdEDRALDVARrVDSGSVGINFFg--SNHSAPFGGRHDSGMGVEYG-IEGLSAYLSYKS 497 Corynebacterium...
YP_001508870 403 DDEAVRLANDSEFGLGGGVWAQsPVRAYEIAKrLRTGMIYINGGgagSSPHTAFGGYKQSGLGLERG-EFGLEEFLLSKS 481 Frankia sp. EAN...
YP_714390    403 DDEAVRLANDSDFGLGGGVWSGdPTRAYRIGGrIRAGMVSLNGGtggLSPHGPFGGYKASGIGREWG-KWGLSEFLQHKS 481 Frankia alni AC...
YP_615953    407 DDEAIALANASDFGLSGAIYSAdAGQAYRMALkIRTGGVSINGGagtMQSDAPFGGIKRSGYGREYG-EDGLNEFTYQKV 485 Sphingopyxis al...
ZP_01301841  412 DEEAIRIANDSRYGLNGGIETAdAAKGYEMAMhIRAGSVMLNGGt-gRMTYAPIGGYKRSGVGREYG-PDWLHEYQNQKS 489 Sphingomonas sp...
YP_002087356 412 DDEAIAIANDSRYGLNGGILSAdAATAYRMARrIRAGSVYLNGGg-gGLPYAPIGGYKRSGIGREFG-PDWLKEFSQEKS 489 Pseudomonas aer...
YP_289348    410 VDEAIRLANDTAYGLAANVWAPtLEEGRRVAEqLRAGTVWINGGg-aMRPDAPFGGSGRSGIGRELG-EWGIQEFLEPRH 487 Thermobifida fu...
AAL14238     395 EEDAVRIANDSEYGLRGGVWSRdVDRARAVAArMRTGQVMINGGe--FNPNAPFGGYKQSGTGREFG-THGLEEFLEIKS 471 Rhodococcus ruber
NP_961517    405 DDDAVAIANNSRYGLSGAVWGDdVDRAVGVARrIRTGQIAVNGI---SPAGAPFGGFRLSGLGREGGgIGGLHQYMEPMA 481 Mycobacterium a...

Feature 1           
3B4W_A       478 VLL 480 Mycobacterium tuberculosis H37Rv
NP_737165    498 IHR 500 Corynebacterium efficiens YS-314
YP_001508870 482 IIW 484 Frankia sp. EAN1pec
YP_714390    482 LVW 484 Frankia alni ACN14a
YP_615953    486 IGF 488 Sphingopyxis alaskensis RB2256
ZP_01301841  490 VFY 492 Sphingomonas sp. SKA58
YP_002087356 490 IIY 492 Pseudomonas aeruginosa 2192
YP_289348    488 IQW 490 Thermobifida fusca YX
AAL14238     472 LQF 474 Rhodococcus ruber
NP_961517    482 IGV 484 Mycobacterium avium subsp. paratuberculosis K-10

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