Conserved Protein Domain Family
Ig1_Contactin-1
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cd05849: Ig1_Contactin-1 (this model, PSSM-Id:143257 is obsolete and has been replaced by 409436)
First immunoglobulin (Ig) domain of contactin-1
Ig1_Contactin-1: First Ig domain of the neural cell adhesion molecule contactin-1. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.
Links
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Statistics
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PSSM-Id: 143257
Aligned: 3 rows
Threshold Bit Score: 206.347
Created: 11-Jan-2008
Updated: 18-Aug-2016
Structure
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Aligned Rows:
Download Cn3D
 
interdomain
Feature 1:interdomain interface [polypeptide binding site]
Evidence:
  • Comment:Based on similarity to chicken axonin-1 (contactin-2).
  • Comment:Chicken axonin-1 domains Ig1 and Ig4 interact with each other, helping to form the U shaped structure of the intermolecular binding fragment.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         ##                                                                              
Q12860         40 GPIFEEQPINTIYpeeslegkVSLNCRarasPFPVYKWRMnngdvdltsdRYSMvgGNLVINNPdkqkDAGIYYCLASNn 119  human
P14781         32 GPVFEEQPIDTIYpeessdgqVSMNCRaravPFPTYKWKLnnwdidltkdRYSMvgGRLVISNPeksrDAGKYVCVVSNi 111  chicken
NP_001079338   24 GPVFEEQPIDTIFpeestegkVSVNCRargnPPPIYKWRKnnleidllneHYSLvgGNLVINNPdkykDSGRYVCIVSNi 103  African clawe...

Feature 1          ####        
Q12860        120 yGMVRSTEATLSF 132  human
P14781        112 fGTVRSSEATLSF 124  chicken
NP_001079338  104 yGKVWSREATLNF 116  African clawed frog

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