1Y57,1YOM,2OIQ,2SRC,2PTK


Conserved Protein Domain Family
PTKc_Src

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cd05071: PTKc_Src (this model, PSSM-Id:133202 is obsolete and has been replaced by 270656)
Click on image for an interactive view with Cn3D
Catalytic domain of the Protein Tyrosine Kinase, Src
Protein Tyrosine Kinase (PTK) family; Src kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) tyr kinase, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function.
Statistics
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PSSM-Id: 133202
Aligned: 8 rows
Threshold Bit Score: 530.008
Created: 22-May-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # ###   #           # #                                          ##
1Y57_A    179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 258 human
1YOM_B     10 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 89  human
2OIQ_A     13 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 92  chicken
2SRC_A    179 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 258 human
2PTK_A    180 WEIPRESLRLEVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGNmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 259 chicken
P13116    259 WEIPRDSLRLELKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 338 African clawed frog
CAF06181  261 WEIPRDSLRLDVKLGQGCFGEVWMGTWNgTTRVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 340 zebrafish
CAA45924  254 WEIPRESLRLEVKMGQGCFGEVWRGTWNgTTQVAIKTLKPGTmsPEAFLQEAQVMKKLRHEKLVQLYAVVSeePIYIVTE 333 Xiphophorus xiphidium
Feature 1     ##  #                                         #   ## #          #               
1Y57_A    259 YMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 338 human
1YOM_B     90 YMnKGSLLDFLKgetgkyLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEWTAR 169 human
2OIQ_A     93 YMsKGSLLDFLKgemgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 172 chicken
2SRC_A    259 YMsKGSLLDFLKgetgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 338 human
2PTK_A    260 YMsKGSLLDFLKgemgkyLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLGRLIEDNEYTAR 339 chicken
P13116    339 YMsKGSLLDFLKgemgryLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 418 African clawed frog
CAF06181  341 YMgQGSLLDFLKgdmgkmLRLPQLVDMASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTAR 420 zebrafish
CAA45924  334 FMdQGSLLEFLKgqystmLRLPQLVDFASQIASGMAYVERMNYVHRDLRAANILVGDNLVCKVADFGLARLIEDNEYTAR 413 Xiphophorus xiphidium
Feature 1      #####        #                                 #                               
1Y57_A    339 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 418 human
1YOM_B    170 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 249 human
2OIQ_A    173 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 252 chicken
2SRC_A    339 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 418 human
2PTK_A    340 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 419 chicken
P13116    419 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPPDCPESLHDLMFQCW 498 African clawed frog
CAF06181  421 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKgRVPYPGMVNREVLDQVERGYRMPCPAECPDSLHELMLTCW 500 zebrafish
CAA45924  414 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLVELATKgRVPYPGMVNREVLDQVERGYRMPCPSECPASLHELMLNCW 493 Xiphophorus xiphidium
Feature 1                           
1Y57_A    419 RKePEERPTFEYLQAFLEDYFT 440 human
1YOM_B    250 RKePEERPTFEYLQAFLEDYFT 271 human
2OIQ_A    253 RKdPEERPTFEYLQAFLEDYFT 274 chicken
2SRC_A    419 RKePEERPTFEYLQAFLEDYFT 440 human
2PTK_A    420 RKdPEERPTFEYLQAFLEDYFT 441 chicken
P13116    499 RKdPEERPTFEYLQAFLEDYFT 520 African clawed frog
CAF06181  501 RKePEERPTFEYLQGFLEDYFT 522 zebrafish
CAA45924  494 RKeAEERPTFEYLQGFLEDYFT 515 Xiphophorus xiphidium

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