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cd00082: HisKA 
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Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Links
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Statistics
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PSSM-Id: 119399
View PSSM: cd00082
Aligned: 463 rows
Threshold Bit Score: 30.2584
Threshold Setting Gi: 6226671
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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phosphorylationdimer interface
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:phosphorylation site [posttranslational modification site]
Evidence:
  • Comment:site of trans-autophosphorylation and phosphate transfer reaction
  • Comment:phosphate is transfered to Asp of a downstream response regulator

cd00082 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00082 is a member of the superfamily cl00080.
cd00082:HisKA130181464380111340291301892499557249955411724981730566622667113242651150885981661208318273032168047161845033215925068163309741722872617230613158058861589663217545794155992313122314273913317980436556639811452631222970715596833134727351626370516125841156012911754810213463743122321155984671462671313471220155971721798788915837575162639122808665169041511559718868269161723109254036335540364271237244451722992013475583995181817228042172283481722958617229157163293351723276418033127559778451723116315805917166215021908185417228724172287741722973317231588155982744104349157925462623815122126078172312531136289980252815837931155986581560017517380324170888616126867134728041324253714133665161243931612722316127305161251731612721816126905161267601612720116127853161267401612490516125314161271161723256689539462009109520092182136384057531256172303751546076221809410957449832878621679757746254227485605274854804156414561743374114983057485439712372022353767175498418250139745824787486640674858862156406421561457615614110175477984106623349783567307456251117614133650161242828554300125073771723159717227613155991699656167135239741056333687654613681823410411825465221364925995701988098715894190183102981830996818310969183109681589372818310494158896882765035748550861583745517549895461403161277141588738628016511612554317549660156010061161055156436164661951592448125073791723329233969791561450841046092339695315896466161245447388008130131126446761580619413013041046002182990168046203687664183112211831090818310174183110801830921730254611561482615893582156159876318167825063857263011955415315613717158938554104606158941181680445915614372586204158941501830993315895987173113615613382685653931589360921829921590002816123187158967532854031723052919352184622670711717231680310119746915250076515904038159025731592535215790397158902111579024610803577157911361578989315791011158061931095745017980438172312591988097219880987122304742009013412230457134737221559566133112649318412715602589167647361202061754631758504112020815599392158906771626296018254651798839615600705156003581183951754505017548229155965331559948920141732221364912849429519332160529156130991507696613858017229406172298711559644043761851347667915597373161271069857983158909241347217513470935134739391579469438511811722977424434755713126947825721605281773367172286721723019117232374732226156415294643931559991941716757122826578850752140815616039156144831561436530416956686907156441111561395117063592421266217228686994701558558775536732175447961612478576722451030327170326932880748570039615599690134757111754844113476390134737581834376573203831087684028721117179212859715838447156155112014126298005041451792915896562172314746258421149864011499614114980601589374215893815156440146122996972110076124358599099181580723677992701453010154377825073761754853610553489314131617231994293366298171823615896016195538051807641521829961580577019703921172286872182835159244043599372172326811974594319704595612209282339697415839124172978417158741155966351363279925007667291841560007925007671248456755977759110282957172306591754526817546454183074201754765529610751347658517548120888586015599971172388917549772155959541095740668083971612365475377875399098340194715889800158911691589035117989360680532181580661318311313158948317688293816695781JOY A17549416179891374511975161254333288072171078816127162126425542895935122309692981052540363921754967316123178157937711626474815596355155969951754778283287780156013241560102517547642157925861579255015836992130128155963771564316615613736158968952200155941045961680091915894795130181464380111340291301892499557249955411724981730566622667113242651150885981661208318273032168047161845033215925068163309741722872617230613158058861589663217545794155992313122314273913317980436556639811452631222970715596833134727351626370516125841156012911754810213463743122321155984671462671313471220155971721798788915837575162639122808665169041511559718868269161723109254036335540364271237244451722992013475583995181817228042172283481722958617229157163293351723276418033127559778451723116315805917166215021908185417228724172287741722973317231588155982744104349157925462623815122126078172312531136289980252815837931155986581560017517380324170888616126867134728041324253714133665161243931612722316127305161251731612721816126905161267601612720116127853161267401612490516125314161271161723256689539462009109520092182136384057531256172303751546076221809410957449832878621679757746254227485605274854804156414561743374114983057485439712372022353767175498418250139745824787486640674858862156406421561457615614110175477984106623349783567307456251117614133650161242828554300125073771723159717227613155991699656167135239741056333687654613681823410411825465221364925995701988098715894190183102981830996818310969183109681589372818310494158896882765035748550861583745517549895461403161277141588738628016511612554317549660156010061161055156436164661951592448125073791723329233969791561450841046092339695315896466161245447388008130131126446761580619413013041046002182990168046203687664183112211831090818310174183110801830921730254611561482615893582156159876318167825063857263011955415315613717158938554104606158941181680445915614372586204158941501830993315895987173113615613382685653931589360921829921590002816123187158967532854031723052919352184622670711717231680310119746915250076515904038159025731592535215790397158902111579024610803577157911361578989315791011158061931095745017980438172312591988097219880987122304742009013412230457134737221559566133112649318412715602589167647361202061754631758504112020815599392158906771626296018254651798839615600705156003581183951754505017548229155965331559948920141732221364912849429519332160529156130991507696613858017229406172298711559644043761851347667915597373161271069857983158909241347217513470935134739391579469438511811722977424434755713126947825721605281773367172286721723019117232374732226156415294643931559991941716757122826578850752140815616039156144831561436530416956686907156441111561395117063592421266217228686994701558558775536732175447961612478576722451030327170326932880748570039615599690134757111754844113476390134737581834376573203831087684028721117179212859715838447156155112014126298005041451792915896562172314746258421149864011499614114980601589374215893815156440146122996972110076124358599099181580723677992701453010154377825073761754853610553489314131617231994293366298171823615896016195538051807641521829961580577019703921172286872182835159244043599372172326811974594319704595612209282339697415839124172978417158741155966351363279925007667291841560007925007671248456755977759110282957172306591754526817546454183074201754765529610751347658517548120888586015599971172388917549772155959541095740668083971612365475377875399098340194715889800158911691589035117989360680532181580661318311313158948317688293816695781JOY A17549416179891374511975161254333288072171078816127162126425542895935122309692981052540363921754967316123178157937711626474815596355155969951754778283287780156013241560102517547642157925861579255015836992130128155963771564316615613736158968952200155941045961680091915894795
cd00082 Sequence Cluster
cd00082 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
Feature 1                    #                                                       
1JOY_A         9 ADDRTLLMAGVSHDLRTPLTRIRLATEMMSeq---------dGYLAESINKDIEECNAIIEQFIDYLX 67
gi 15600079  241 YQRLQQFSADLAHEIRTPIGSLMGHGQVALrqprs---neeyQALIASNQEELERIARMVESILFLAR 305
gi 12484567  239 VQQLSQFSDDLAHELRAPLTNLMGKAQLTLsrqrp---pdeyKAVLESNTEELERLARIVSDMLFLAQ 303
gi 6578850   281 LATLGRFSAQMAHDLKNPIAAMKGAAQYLKeehargrswdgqGEFLDLLLEQVERLDRVVDTYQRLAR 348
gi 2500767   233 FERLSQFADDLAHELRTPINALLGQNQVTLsqtrs---iaeyQKTIAGNIEELENISRLTENILFLAR 297
gi 15794694  310 LAALGQLTANLAHEIRNPMSAIRHANDLLRenmeagaadpfnAKLCKIIDGNVCRIDKMLEDISSLNK 377
gi 2443475   378 LASMGRLVASVAHQIRNPLAAISQAAELLDdpg------eggEPLRPEGRGVETRLLRIIRDNVRRLD 439
gi 3851181   310 LAALGQLTANLAHEIRNPMSAIRHADGGTLfvdev--adlplSMQVKLLRAIQEKAVRRIGDATEQPV 375
gi 55977759  240 FVRLSQFSSNLAHDMRTPLTNLLAEAQVALskprt---adeyRDVIESSIDEYQRLSRMIEDMLFLAR 304
gi 110282957 233 YQKLSRFSADLAHDLRTPLNNLIGHAEVALsrdrt---gpeyVALVEESLVEYQRLARMIDAMLFLAR 297

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D