1K1F


Conserved Protein Domain Family
Bcr-Abl_Oligo
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pfam09036: Bcr-Abl_Oligo (this model, PSSM-Id:117602 is obsolete and has been replaced by 430380)
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Bcr-Abl oncoprotein oligomerization domain
The Bcr-Abl oncoprotein oligomerization domain consists of a short N-terminal helix (alpha-1), a flexible loop and a long C-terminal helix (alpha-2). Together these form an N-shaped structure, with the loop allowing the two helices to assume a parallel orientation. The monomeric domains associate into a dimer through the formation of an antiparallel coiled coil between the alpha-2 helices and domain swapping of two alpha-1 helices, where one alpha-1 helix swings back and packs against the alpha-2 helix from the second monomer. Two dimers then associate into a tetramer. The oligomerization domain is essential for the oncogenicity of the Bcr-Abl protein.
Links
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Statistics
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PSSM-Id: 117602
Aligned: 4 rows
Threshold Bit Score: 113.081
Created: 29-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1K1F_C    2 VDPVGFAEAWKAQFPD--SEPPRXELRSVGD--------IEQELERAKASIRRLEQEVNQERFRXIYLQTLLAKEKKSYD 71   human
Q4SA61    2 VEPVGFVEAWRAQFPE--SDPPYMDLNSMGD--------IEQELDKCRDSIRHLEKEVNKERFRMIYLQTLLAKERKSYD 71   spotted green puffe...
Q4T025 1056 VSPLSLAQWPVEKLSRwfQVSVFAACRSRGDrwvslrspLGPAAAACKGSIRRLEQEVNKERFRMIYLQTLLAKERKSYD 1135 spotted green puffe...
Q6NRG7    1 -mlagFAEAWRAQFPD--AEPPRMELRTVRD--------MEQELERCRASVRRLERELNRERFRMIYLQTLLAKERRGYD 69   African clawed frog

1K1F_C   72 R 72   human
Q4SA61   72 G 72   spotted green pufferfish
Q4T025 1136 K 1136 spotted green pufferfish
Q6NRG7   70 R 70   African clawed frog
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