Conserved Protein Domain Family
VPR

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pfam00522: VPR 
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VPR/VPX protein
BioAssay Targets and Results
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CID: 5389021
AID: 651644
GI: 28872817
IC50: 0.2512µM
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qHTS Assay for Inhibitors of the HIV-1 protein Vpr
Chemical Name: AC1NTUUH
IC50: 0.2512µM
CID: 100520
AID: 651644
GI: 28872817
IC50: 1µM
more
qHTS Assay for Inhibitors of the HIV-1 protein Vpr
Chemical Name: AC1L2OWV
IC50: 1µM
CID: 759209
AID: 651644
GI: 28872817
IC50: 1µM
more
qHTS Assay for Inhibitors of the HIV-1 protein Vpr
Chemical Name: AC1LFSK9
IC50: 1µM
Statistics
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PSSM-Id: 109573
View PSSM: pfam00522
Aligned: 13 rows
Threshold Bit Score: 101.698
Threshold Setting Gi: 401406
Created: 28-Mar-2013
Updated: 4-Apr-2013
Structure
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Program:
Drawing:
Aligned Rows:
pfam00522 is a member of the superfamily cl02887.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                      10        20        30        40        50        60        70        80
              ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1ESX_A      1 MEQAPED---QGPQREPYNDWTLELLEELKNEAVRHFPRIWLHSLGQHIYETYgDTWTG-----VEALIRILQQLLFIHF 72
gi 139385   1 MEQAPED---QGPQREPYNEWTLELLEELKREAVRHFPRPWLHSLGQYIYETYgDTWAG-----VEAIIRILQQLLFIHF 72
gi 139407   6 DEQVSED---QGPPREPYNQWLADTMEEIKEEARKHFPLIILNAVSEYCVQNTgSEEEA-----CEKFITLMNRAIWVHL 77
gi 401406   8 REPLPGWleiWDLDREPWDEWLQDMLRDLNEEARRHFGMNMLIRVWNYCVEEG-RRHNTpwneiGYKYYRIVQKSMFVHF 86
gi 139447   4 RERVPPGnsdEETVGEAF-AWLERTITELNRVAVNHLPRELIFQVWQRSWAYWrEEQGMsisytKYRYLLLMQKAMFVHY 82
gi 139450   5 RETVPPGnsgEETIEEAF-AWLDRTVEAINREAVNHHPRELIFQVWQRSWRYWhDEQGMstsytKYRYLCLIQMAMYMHA 83
gi 139445   5 RERVPPGnsgEETIGEAF-EWLERTIEALNREAVNHLPRELIFQVWQRSWRYWhDEQGMsasytKYRYLCLMQKAIFTHF 83
gi 139457   5 RERIPPGnsgEETIGEAF-EWLNRTVEEINREAVNHLPRELIFQVWQRSWEYWhDEQGMsqsytKYRYLCLIQKALFMHC 83
gi 139400   6 PEIPPEN---ENPQREPWEEWIGEILEEIKQEALKHFDPRLLTALGNFIYSRHgDTLAG-----AGELIKILQRALFLHF 77
gi 139408   2 EERPPEN---EGPQREPWDEWVVEVLKELKEEALKHFDPRLLTALGNHIYNRHgDTLEG-----AGELIRILQRALFIHF 73
gi 139399   6 TELPPED---GTPPREPGDEWVIEILRDIKEEALKHFDPRLLTALGGHIYARHgDTLER-----ARELIRVLQRALFTHF 77
gi 139397   6 TEFPPED---GTPRRELGSTWVIETLKEIKEEALKHFDPCLLIALGNYIYNRHgDTLEG-----ARELIRVLQRALFVHI 77
gi 139454   8 REERPGGleiWDLSREPWDEWLRDMVEEINNEAKLHFGRELLYQVWNYCQEEG-ERQGRpiaerAYKYYRLVQKALFVHF 86
                      90       100
              ....*....|....*....|
1ESX_A     73 RIGCR---------HSRIGI 83
gi 139385  73 RIGCQ---------HSRIGI 83
gi 139407  78 AQGCD-------------GT 84
gi 401406  87 RCGCRrrgpfspyeERRNGQ 106
gi 139447  83 TKGCRclq----egHGPGGW 98
gi 139450  84 KRDGTclg----ggMGQKGG 99
gi 139445  84 KRGCTcwg----edMGREGL 99
gi 139457  84 KKGCRclg----egHGAGGW 99
gi 139400  78 RAGCQ---------HSRIGQ 88
gi 139408  74 RSGCS---------HSRIGQ 84
gi 139399  78 RAGCN---------HSRIGQ 88
gi 139397  78 RAGCD---------RSRKGQ 88
gi 139454  87 RCGCRrrqpfepyeERRNGQ 106
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