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cd06464: ACD_sHsps-like 
Click on image for an interactive view with Cn3D
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.
Statistics
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PSSM-Id: 107221
View PSSM: cd06464
Aligned: 813 rows
Threshold Bit Score: 27.9037
Threshold Setting Gi: 149431914
Created: 8-Jul-2008
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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Display:
 
putative dimer
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:putative dimer interface [polypeptide binding site]
Evidence:
  • Structure:2H50, Saccharomyces cerevisiae Hsp26 dimer interface, contacts at 3.5 A
    View structure with Cn3D
  • Comment:ScHsp26 assembles in shell-like particles composed of 24 subunits. These particles are storage forms which upon heat shock disassociate into dimers. Non-native substrate proteins bind the disassociated ScHsp26 and assemble into large globular assemblies having one monomer of substrate bound per dimer.
  • Structure:1GME_A, Triticum aestivum sHsp dimer interface, contacts at 3.5 A
    View structure with Cn3D
  • Comment:T. aestivum HSP16.9 assembles as a 12-mer, comprised of two discs, each disc having 6 alpha crystallin-like domains organized as a trimer of dimers.

cd06464 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd06464 is a member of the superfamily cl00175.
cd00237:p23cd00298:ACD_sHsps_p23-likecd06463:p23_likecd06464:ACD_sHsps-likecd06465:p23_hB-ind1_likecd06466:p23_CS_SGT1_likecd06467:p23_NUDC_likecd06468:p23_CacyBPcd06469:p23_DYX1C1_likecd06470:ACD_IbpA-B_likecd06471:ACD_LpsHSP_likecd06472:ACD_ScHsp26_likecd06475:ACD_HspB1_likecd06476:ACD_HspB2_likecd06477:ACD_HspB3_Likecd06478:ACD_HspB4-5-6cd06479:ACD_HspB7_likecd06480:ACD_HspB8_likecd06481:ACD_HspB9_likecd06482:ACD_HspB10cd06488:p23_melusin_likecd06489:p23_CS_hSgt1_likecd06490:p23_NCB5ORcd06492:p23_mNUDC_likecd06493:p23_NUDCD1_likecd06494:p23_NUDCD2_likecd06495:p23_NUDCD3_likecd06497:ACD_alphaA-crystallin_HspB4cd06498:ACD_alphaB-crystallin_HspB5cd06526:metazoan_ACD2BOL A7615553712935913625983567526632BOL A136259831293595675266315640268238146755189237769158591842719970897657146507566971839865931482320081985507314823201423227760162577409625747221507148922961117385616612860147265054040814822727522096351601627111734660147241173446014722472271576016268483740496295546167083955476781261160905658370116124643312719827551159179944842799474096307932112101500218287201601215860132317550410123542585269123535749645281339016801705916644657811585996461754110215640174515636367717559394557360251264387754400582118101135148236309149383936156375673156362234156348268474965751181037801639162341508325144657663546576643232279117425618355855803755816796346415181257199532211553429015859355970905472232085461195875682667151705779711586025461585985551585927812458322224661523246603811235811700387181571269106165165285816366552479701571355339171882813124197113208389167882442156105767109290395667727871553693199108914791089145152031623871167778711677541394383118429547761527681455595111263225331494319145073180456756727685687331563169512829826117620203500860651347278469936685833113141707875011034875541347266515298179113488471182676953813449581344966856872983859885161264971529978901499264061108346387060841658040820108405484704530149908184710828867072477950470482813450131982990813450018359953216760643168021608163726310156083693160872457169646838152993054126466170323945103799974811860244566805533157734252674712891832318891167836761255320843141596821592618152421072441744215209179125580130108710175108706271125574911152237291522835248475229115437996537933831198620066807257378369692193811087425265391235601594631821594752122H50 A2H50 B1GME A1GME B2BYU A1591389351167808331154439731680364731235621163102264185748168063824116793157152403081486156451167937601154647291842365411499553774655793122232123564116792926116781306306952431184856181255312035025287312553120122530884116780839399938887664016601536152190281255936221255385151160565911453448309592906015607392134096767849962531302207819380800678368732783696905197974279388166827703164646271164636231509808341700995471340990005189208485858215249533611682051179273701691561131691773261166706671500350121166726731204048956121707139132964657988278357051187934468150019838182418677161201428537265512452283789099865149183183138895738171323604569639091561483514992252911994550216776047716774556815381212315450044715385320115448640111943408516091479316093867916381594316603077516776161016935161716089400716468698816094438444888020162447286146297061169121642121534582124522269892104441184438851609322991544998871637904537366181239130994278135411456613411633278712597560389896413183223726171779968282120534623231824165171500189351166180858142766528379699283770771164933711164942351164962221771143920890654251826711649038969249077283791771462796283386689527650305119477493116055729668150551242665891215951431180509109178912412160520112426724774318330827022961340955121579347071138679931754491934496632743173881590398822262172168023258171911394182412747153893364182414200110669221768015211538941855537846555378605157895657680328615790691157907161538953255537901315389532476801191110667764886021091938106911615292161185766931463040601589933048477811126008230135416061608191716983128389097848147676965183138361262501661576927254644743888801467685500307818657316983164410876305116784034211994499516983165014826487315395542515904241118313876114988941702898551240281151184316571264653701569381501589917611971936411675411612600863648477493160815907680066055379036157894221106673551538941979177435320093358200933571185770181SHS A1638000441702899992122658921227062212270631261802631197196854161513211675492011971941915904102918313227844892171567887991773920200890322009239014535463912347242612342870418645574718645747918241274815389336317191139583646752263950895429532971019595755361847553574189257193208089285869879488601898192822681873090191491772971240044641463021471637559601204366401637880378871370511063665814927568529345975149280426189502167163757287124007609124005507888061488989082412664667978486361345576611577384831541490813455882614919517442524139425249731895006352167347621674781152991975787767141197767124252248710880385111662614115300593515300617911662145011792464839995645145618001949717911637651201637657281153752021580613446199422121998967302500142124190577166188838149978381674916753600916752220416751720511678476616881221023227411544504514779644541857601679991211154490752161811511678549111605612411674870818921984415388646517191532751245718836429531245151869449934587300671114775493158522533159045336737487221624488475489631624532318331199685373655179346415134721771613786756753081621472261482592201529734561615254571572733081637263111923590295284240578356781163701355161525554858595641449004741499151611538874401626305827383072116251648182678004269899521885830991707441591879201871675863381530117771034858841098998831637239971707901311676468191503856581637261881594711951476784599120020385857896912005861637254439120427014917304953803940564769732699003077166189827022997431746312751123039997503668203301112268901564314216090298618942586311858101714562095339998282912016941677307691638459001180471401637262998586015415852111416795714615395480089895308147677663835913211080271212597256151892890156065001889970741459159192113554771650575380491977917984145620279861592853999777283589336518925374278134312448611415415115088601471126179701126179965126179440171326382109565195208084616746395215613043149174721171325332167776001912036601585226531637263931167497959426601211674917724214264399975059593052277917972168701993324763511347395615301177910348588685857898148258954888115889211537112487969453803942564769712699003212160423014919949016988494689901776187920403148554069188582982273812841827041233359571211949036315834073486607752375222721194930881195132151722930115902744256751713163295881583407881583361311134766191590278512009344216378406418899606616772911289210955188585215668197976681426467649663147225171461994186747247567482291167462860890960072381384578044356238223761455117061183472081455508981454887596680802718413934123221613069584115734725912270361211848663015727968515912631615428267915429399816959931814523459750547857505478595055339429561445184696451909844519915124953351568433241486560631638486641486543781598974651110251437216161886740625117928681721619301235731452558468508989519073387115401850169785114119479271145251115170089979169858388746547661491770684619851115806694559815909120323318646095512451529914917363194266500171914099186456154159898144771648861698306507835639046580845783581321167497941167491781637263941491747209426601114825895585857897324763521347395715301177891200204912036594658084612060334578358131779179733999750495930523103485885269900315647697217106005016982079112160423116244884688811589921153701864598491677760002BOL A7615553712935913625983567526632BOL A136259831293595675266315640268238146755189237769158591842719970897657146507566971839865931482320081985507314823201423227760162577409625747221507148922961117385616612860147265054040814822727522096351601627111734660147241173446014722472271576016268483740496295546167083955476781261160905658370116124643312719827551159179944842799474096307932112101500218287201601215860132317550410123542585269123535749645281339016801705916644657811585996461754110215640174515636367717559394557360251264387754400582118101135148236309149383936156375673156362234156348268474965751181037801639162341508325144657663546576643232279117425618355855803755816796346415181257199532211553429015859355970905472232085461195875682667151705779711586025461585985551585927812458322224661523246603811235811700387181571269106165165285816366552479701571355339171882813124197113208389167882442156105767109290395667727871553693199108914791089145152031623871167778711677541394383118429547761527681455595111263225331494319145073180456756727685687331563169512829826117620203500860651347278469936685833113141707875011034875541347266515298179113488471182676953813449581344966856872983859885161264971529978901499264061108346387060841658040820108405484704530149908184710828867072477950470482813450131982990813450018359953216760643168021608163726310156083693160872457169646838152993054126466170323945103799974811860244566805533157734252674712891832318891167836761255320843141596821592618152421072441744215209179125580130108710175108706271125574911152237291522835248475229115437996537933831198620066807257378369692193811087425265391235601594631821594752122H50 A2H50 B1GME A1GME B2BYU A1591389351167808331154439731680364731235621163102264185748168063824116793157152403081486156451167937601154647291842365411499553774655793122232123564116792926116781306306952431184856181255312035025287312553120122530884116780839399938887664016601536152190281255936221255385151160565911453448309592906015607392134096767849962531302207819380800678368732783696905197974279388166827703164646271164636231509808341700995471340990005189208485858215249533611682051179273701691561131691773261166706671500350121166726731204048956121707139132964657988278357051187934468150019838182418677161201428537265512452283789099865149183183138895738171323604569639091561483514992252911994550216776047716774556815381212315450044715385320115448640111943408516091479316093867916381594316603077516776161016935161716089400716468698816094438444888020162447286146297061169121642121534582124522269892104441184438851609322991544998871637904537366181239130994278135411456613411633278712597560389896413183223726171779968282120534623231824165171500189351166180858142766528379699283770771164933711164942351164962221771143920890654251826711649038969249077283791771462796283386689527650305119477493116055729668150551242665891215951431180509109178912412160520112426724774318330827022961340955121579347071138679931754491934496632743173881590398822262172168023258171911394182412747153893364182414200110669221768015211538941855537846555378605157895657680328615790691157907161538953255537901315389532476801191110667764886021091938106911615292161185766931463040601589933048477811126008230135416061608191716983128389097848147676965183138361262501661576927254644743888801467685500307818657316983164410876305116784034211994499516983165014826487315395542515904241118313876114988941702898551240281151184316571264653701569381501589917611971936411675411612600863648477493160815907680066055379036157894221106673551538941979177435320093358200933571185770181SHS A163800044170289999212265892122706221227063126180263119719685416151321167549201197194191590410291831322784489217156788799177392020089032200923901453546391234724261234287041864557471864574791824127481538933631719113958364675226395089542953297101959575536184755357418925719320808928586987948860189819282268187309019149177297124004464146302147163755960120436640163788037887137051106366581492756852934597514928042618950216716375728712400760912400550788806148898908241266466797848636134557661157738483154149081345588261491951744252413942524973189500635216734762167478115299197578776714119776712425224871088038511166261411530059351530061791166214501179246483999564514561800194971791163765120163765728115375202158061344619942212199896730250014212419057716618883814997838167491675360091675222041675172051167847661688122102322741154450451477964454185760167999121115449075216181151167854911160561241167487081892198441538864651719153275124571883642953124515186944993458730067111477549315852253315904533673748722162448847548963162453231833119968537365517934641513472177161378675675308162147226148259220152973456161525457157273308163726311192359029528424057835678116370135516152555485859564144900474149915161153887440162630582738307211625164818267800426989952188583099170744159187920187167586338153011777103485884109899883163723997170790131167646819150385658163726188159471195147678459912002038585789691200586163725443912042701491730495380394056476973269900307716618982702299743174631275112303999750366820330111226890156431421609029861894258631185810171456209533999828291201694167730769163845900118047140163726299858601541585211141679571461539548008989530814767766383591321108027121259725615189289015606500188997074145915919211355477165057538049197791798414562027986159285399977728358933651892537427813431244861141541511508860147112617970112617996512617944017132638210956519520808461674639521561304314917472117132533216777600191203660158522653163726393116749795942660121167491772421426439997505959305227791797216870199332476351134739561530117791034858868585789814825895488811588921153711248796945380394256476971269900321216042301491994901698849468990177618792040314855406918858298227381284182704123335957121194903631583407348660775237522272119493088119513215172293011590274425675171316329588158340788158336131113476619159027851200934421637840641889960661677291128921095518858521566819797668142646764966314722517146199418674724756748229116746286089096007238138457804435623822376145511706118347208145550898145488759668080271841393412322161306958411573472591227036121184866301572796851591263161542826791542939981695993181452345975054785750547859505533942956144518469645190984451991512495335156843324148656063163848664148654378159897465111025143721616188674062511792868172161930123573145255846850898951907338711540185016978511411947927114525111517008997916985838874654766149177068461985111580669455981590912032331864609551245152991491736319426650017191409918645615415989814477164886169830650783563904658084578358132116749794116749178163726394149174720942660111482589558585789732476352134739571530117789120020491203659465808461206033457835813177917973399975049593052310348588526990031564769721710600501698207911216042311624488468881158992115370186459849167776000
cd06464 Sequence Cluster
cd06464 Sequence Cluster
Sub-family Hierarchy
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 cd06464 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        #####          # # ##                                        #                  
2BOL_A       102 DAYEVgkdgrlHFKVYFNVKN-FKAEEITIKADknKLVVRAQksvacg----daamsESVGRSIpLPPSVDRnhIQATIT 176
gi 156375673  54 KSADK------VTIATLDIGR-YRPEDITWSVEddHVLICGKhcakts----rgaegGKFVRSIpLPEDIKTqsVTARFC 122
gi 156362234   1 MEGDK------VEIATLDVKN-YRPEEISLKVEhgRIKIDGKhksege----hgyetSEFHRSYnLPDGVDVstVSSRIT 69
gi 156348268   1 MDADK------FQIATLDVRE-FKPEEITCKVEngKIKVSGLqrhese----egfdsKEFRRCYnLPEGVDEssISTRIA 69
gi 47496575   63 PPREGk----sHFQILLDVVQ-FLPEDIIIQTFegWLLIKAQhgtrmd---ehgfisRSFTRQYkLPDGVEIkdLSAVLC 134
gi 118103780  62 SQEEEk----tGFQVLLDVVQ-FRPEDIIIQTFegWLLIKAQhgprmd---ehgfisRSFTRQYkLPDGVENkdLSALFC 133
gi 163916234  52 QQEEDd-----KFKVLLDVVQ-FRPEDIIIQVFegWLIIKGEhgcrmd---ehgfisRSFTRTYqLPNGIGLtdLSAFFC 122
gi 13625983  230 DEATGg----eKLHVEVPIEPeFTADDLCVRMDanRVIVSGQkkyvdetassksahvKEFTRSYeIPETVDTfsVNSQLH 305
gi 129359    261 DDGSGg----kRLHVEVAVDPvYKPEDLFVNVDsnRVVVSGRhhkqksdqhgrsssfAEFSQSYaIPETVDPlsVSAQVV 336
gi 56752663  384 GINGRk----lHLEVTVDSIY-KADELCVRMDSn-CIVISGCqkkteg----sssstAEFTQSFeIPETVDPfsVTAQLI 453
                         90
                 ....*....|..
Feature 1           ##       
2BOL_A       177 t-dDVLVIEAPV 187
gi 156375673 123 mrdGQLIVEGTK 134
gi 156362234  70 g-dGLLHIEALK 80
gi 156348268  70 e-dGMLHVEALK 80
gi 47496575  135 h-dGILVVEVKD 145
gi 118103780 134 h-dGILVVEMKN 144
gi 163916234 123 h-dGILAVEGKQ 133
gi 13625983  306 g--NTLLVEAPL 315
gi 129359    337 g--NTLVLEAPL 346
gi 56752663  454 g--TTLVVEAPL 463

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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Click on image for an interactive view with Cn3D
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D