CDD Conserved Protein Domain Family: WSD

pfam15613: WSD, with user query added

Williams-Beuren syndrome DDT (WSD), D-TOX E motif

This family represents the combined alpha-helical module found in diverse eukaryotic chromatin proteins. Based on the Ioc3 structure, the N-terminus of this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes. The acidic residue from the GxD signature at the N-terminus is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA. The WSD module constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA, and was first identified as WSD, the D-TOX E motif of plant homeodomains homologous with the mutant transcription factor causing Williams-Beuren syndrome in association with the DDT-domain.

query 1363 LRSMMFGQDRYRRRYWIL PQCGGIFVEGM.[1].S GE 1395 GAC98411 814 SRMTPLGRDRFGDKYWWF.[16].YQTGRLFIQGA.[1].L.[50].NE 912 CCA67434 788 SRMQPLGYDRFHSKIWWF.[16].YGTGKLFIQGP.[1].Q.[31].GE 867 EGO04257 755 IRVKPLGRDRFYNRIWWF.[16].YGTGRIFVQGP.[1].I.[30].GE 833 XP_002958970 1163 IRAEPLGSDRRYNRYWLF.[ 7].AGSGRLWVESA.[1].E GT 1202 ERN06574 1136 YRSLPLGQDRRRNRYWRF.[ 7].PGCGRIFFESH D GC 1174 EFH67034 1106 YRSLPLGQDRRHNRYWHF.[ 8].PCSGLLFVELH D GK 1145 XP_003593644 1141 YRSLPLGQDRRRNRYWQF.[ 8].PGSGRIFVEHH D GS 1180 EFH41638 1072 YRSLPLGQDRRRNRYWRF.[ 8].PGCGRIFVELQ D GR 1111

Conserved Protein Domain FamilyWSD

Conserved Protein Domain Family
WSD