4ZMI,4RQI,6K5S


Conserved Protein Domain Family
TRF

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pfam08558: TRF 
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Telomere repeat binding factor (TRF)
Telomere repeat binding factor (TRF) family proteins are important for the regulation of telomere stability. The two related human TRF proteins hTRF1 and hTRF2 form homodimers and bind directly to telomeric TTAGGG repeats via the myb DNA binding domain pfam00249 at the carboxy terminus. TRF1 is implicated in telomere length regulation and TRF2 in telomere protection. Other telomere complex associated proteins are recruited through their interaction with either TRF1 or TRF2. The fission yeast protein Taz1p (telomere-associated in Schizosaccharomyces pombe) has similarity to both hTRF1 and hTRF2 and may perform the dual functions of TRF1 and TRF2 at fission yeast telomeres. This domain is composed of multiple alpha helices arranged in a solenoid conformation similar to TPR repeats. The fungal members have now also been found to carry two double strand telomeric repeat binding factors.
Statistics
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PSSM-Id: 400735
Aligned: 27 rows
Threshold Bit Score: 108.26
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

4ZMI_A          1 .[2].WDIEKA.[5].DCQNIANMAEQKVM.[15].P     ESFSERLGK     ETVKDLYE.[1].NE.[30].LEK 96   Schizosaccharomyce...
Q4QRH9         15 .[2].WSFDFY     AFQAFSAFRNGDYT      A.[2].HFINIIESV.[1].VRPVDGHT.[1].MI.[ 4].LMQ 67   zebrafish
Q9PU53         28 .[2].WVLQFY     FHQAVAAYRAGRNR      D.[2].QLRDVMQAL.[1].VRPLEREP.[1].VA.[ 4].VMQ 80   chicken
AAI52523       31 .[2].WIIDYY     FATLCRHFRERSSV      E.[2].KELKLFEGL.[1].DELESHSS.[1].RT      VCC 79  
Q2LK75         18 .[2].WMCDFM     FASMCFYFREDRTE      D.[2].RSTHMLEWL.[1].EGSQKIDA.[1].RK.[ 3].IAQ 69   African clawed frog
P54274         75 .[2].WMLDFL     CLSLCRAFRDGRSE      D.[2].RTRNSAEAI.[1].HGLSSLTA.[1].QL.[ 4].ICQ 127  human
4RQI_C         11 .[2].WVLKFY     FHEALRAFRGSRYG      D.[2].QIRDIMQAL.[1].VRPLGKEH.[1].VS.[ 4].VMQ 63   human
Q1WM12         24 .[2].WAFDYY     FHTAVEAFRSDRHE      D.[2].EIRDIVSVL.[1].LRPLETKA.[1].ND.[ 4].IMQ 76   African clawed frog
Q2GV64        289 .[2].PVLGNI     AVQILLRLSQQPRT.[11].E.[2].KAYDMLRDI.[1].RPTRKAFS     DS.[14].DRE 361  Chaetomium globosu...
XP_001585495  151 .[2].LSLESL     SVQMLNILSEGGYD.[11].P.[2].QSFQTLKDL.[1].DRTKKIYG.[1].ST.[13].QRE 223 

4ZMI_A         97 PLKSIQFFTGLIDLLDNTN     KHLTLRSIVLDAL.[6].DSF.[3].ALVL.[3].LVIRYFGTD     SNPSIDA 163  Schizosaccharomyce...
Q4QRH9         68 FLSRINNGDKLDLTFEEPK     TPLESALDVLESI.[4].SVP.[3].QQLI.[3].ISEVLVMVC.[1].RSGEFEK 133  zebrafish
Q9PU53         81 FLSRIEEGENLDCTFDKET.[2].TPLESAIGILQLI.[4].SVP.[3].IELI.[3].LKEAAVIVC.[2].NKEFSKA 149  chicken
AAI52523       80 FLARVMDGENLDVRYDHVA.[2].TPLMSAVPVWESL     KDF.[5].HGKI.[3].LMVQSVAVC.[2].KGYDKLA 146 
Q2LK75         70 FLMRVAEGKNLDSQFDTDE.[2].TPLETALMAFNQI.[3].EDL.[3].HEEI.[3].LKVQAVVTC.[2].KGRFKLS 137  African clawed frog
P54274        128 FLTRIAAGKTLDAQFENDE.[2].TPLESALMIWGSI.[4].DKL     HEEI.[3].IKIQAIAVC.[2].NGNFKEA 193  human
4RQI_C         64 CLSRIEEGENLDCSFDMEA.[2].TPLESAINVLEMI.[7].EAV.[3].SRKL     VKEAAVIIC.[2].NKEFEKA 132  human
Q1WM12         77 CISRIEEGEDPDCTFNDNN.[2].TPLESAVGLLDII.[7].EDL.[3].NKQM     VKEAAVLVC.[2].KQKFDQA 145  African clawed frog
Q2GV64        362 TIRMSNLAATAASVFGAHD.[1].AVHDVHDAFFSIF.[4].GEY.[3].LTDL.[3].LKTRMLLDA.[3].PEQSQPV 430  Chaetomium globosu...
XP_001585495  224 IIRLANHATFVTSVFGGQE.[1].GFYELNEHFVDIW.[4].EPI.[3].SGQL.[3].LKTQIIVAA.[3].EESDRPV 292 

4ZMI_A        164 SEFILSCLPYTSL.[17].DFLKSTIGNTSNSP     LQLRASFPAFVNAVIH 223  Schizosaccharomyces pombe 972h-
Q4QRH9        134 AEEMLKHFSSSSD.[ 1].AGKKKLLLNLIRCR.[5].VLQLSSYSHFKQDMLQ 182  zebrafish
Q9PU53        150 LAVLKRHMEKDTG.[ 1].QKKRTELQTIIREK.[5].IIRDFSYVNFQQYMFQ 198  chicken
AAI52523      147 KETLQWLEEQTDV.[ 1].EKLQRKLATIVNKK.[5].ILMNFSFDELMETIDT 195 
Q2LK75        138 AEILDRLFKESGS.[ 1].KYLRMKLTMLIEKK.[5].FLQNFTYAQMMKKIKS 186  African clawed frog
P54274        194 EEVFERIFGDPNS.[ 1].MPFKSKLLMIISQK.[5].FFQHFSYNHMMEKIKS 242  human
4RQI_C        133 SKILKKHMSKDPT.[ 1].QKLRNDLLNIIREK.[5].VIQNFSYETFQQKMLR 181  human
Q1WM12        146 IRILKKYISNYSK      RKLRAELHTIIREK.[5].LITNFSFTTIKKMIYQ 193  African clawed frog
Q2GV64        431 SQLLDALFPVTFE.[23].RETREQLVKSAADE.[5].LEDQSSSLKFTGILST 501  Chaetomium globosum CBS 148.51
XP_001585495  293 PELIAEMFSSEIR.[22].EIRRVYLINQGNDP.[5].LCNLFNWESFLRSTHI 362 
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