2LOZ,2CY4


Conserved Protein Domain Family
PTB

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pfam08416: PTB 
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Phosphotyrosine-binding domain
The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.
Statistics
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PSSM-Id: 429984
Aligned: 12 rows
Threshold Bit Score: 162.13
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

2LOZ_A         13 ACSVLYLTSVETESL.[2].PQAVAR     ASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFF.[1].RHYPVNS 80   human
AAI02415       51 QYHVQHLATFIMDKS.[2].ITSVED.[2].RKLVQLSSKEKIWTQEMLLQVNDQSLRLLDMESQEEL     ENFPLPS 119 
Q9VHC3        580 ATNVLWLYSCDTESL.[2].NEAIRK     AIRQMYGQQPLPQPTEVHFKVSSQGITLTDNTRKKFF.[1].KHYKADV 647  fruit fly
Q68CZ2       1310 ACNVWYLNSVEMESL.[2].HQAIQK     ALSITLVQEPPPVSTVVHFKVSAQGITLTDNQRKLFF.[1].RHYPVNS 1377 human
Q0P4Q6         61 QYHIEHLTTFVMDRK.[2].VLTVDD.[2].RKLKLLDAKGKVWTQDMLLQVDDKGVSLYDVDTKSEL     ENFPLSS 129  tropical clawed frog
Q08509         64 QYRVEHLTTFVLDRK.[2].MITVED.[2].RKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNEL     ENFPLNT 132  house mouse
XP_005168553   51 QYHVEHLTTFVMDRK.[2].MLTIED.[2].RKLRLLDAKGKIWTQDMLLQVDNRAVSLIDHDSKNEL     ENFPLGS 119 
Q8TE68         35 QYPVNHLVTFCLGED.[2].VHTVED.[2].RKLAVMDSQGRVWAQEMLLRVSPDHVTLLDPASKEEL     ESYPLGA 103  human
NP_001192218   28 QHRVEHLMTCKLGTQ.[1].IQEPKD.[2].QKLQEMDAQGRVWSQDLLLQVRDGWLQLLDIETKEEL     ESYRLDR 95  
XP_012817032   51 QHRVEHLLTCDLDKE     LRNVED.[2].KHLSFLEAQGRIWGQGLILQLENGEILLKDPETKDSL     EQLPLQN 117 
2CY4_A         10 QYHVNHLVTFCLGEE.[2].VHTVED.[2].RKLAVXDSQGRVWAQEXLLRVSPSQVTLLDPVSKEEL     ESYPLDA 78  
CAG06824       64 QYRVEHLFTFELDGR.[1].LRNVSD.[2].EQLQLLEEMGRVWGQSMLLQVQPPRLLLTDIETKMEL     ESVAIGD 131  spotted green puff...

2LOZ_A         81 ITFSSTDPQDRRWTN.[7].IFGFVAK.[2].GSPWENV.[1].HLFA     ELDPDQPAGAIVTFI.[4].LGQ 145  human
AAI02415      120 VRHSQTVLNQLRYPS     VLLLVCQ.[2].DQSKPDV     HFFH.[2].EVEAELVQEDIESAL.[4].LGK 178 
Q9VHC3        648 ISHCAIDPENRMWTS.[8].IFAFVAR.[2].HSSTDNQ.[1].HVFC     DLSVSQPAAAIVSFA.[4].PTE 713  fruit fly
Q68CZ2       1378 VIFCALDPQDRKWIK.[6].VFGFVAR.[2].GSATDNV.[1].HLFA     EHDPEQPASAIVNFV.[4].IGS 1441 human
Q0P4Q6        130 VQHCQAVMNACRYDS     ILALVCK.[2].AQSKADL     HLFQ.[2].EIKASLVQRDIDSAI.[4].GGK 188  tropical clawed frog
Q08509        133 ISHCQAVVHACSYDS     ILALVCK.[2].TQSKPDL     HLFQ.[2].EVKANLISEDIESAI.[4].GGK 191  house mouse
XP_005168553  120 IQHCQPVTNACSYDS     ILALVCK.[2].GQGKPDL     HLFQ.[2].DIKASLIHMDIESAI.[4].GGK 178 
Q8TE68        104 IVRCDAVMPPGRSRS     LLLLVCQ.[2].ERAQPDV     HFFQ.[2].RLGAELIREDIQGAL.[4].SGR 162  human
NP_001192218   96 IKVMDVALNTGSYNS     VLSITVQ.[2].DLRSTST     LLFQ.[2].EVGAERLKTSLEKAL.[4].EQR 154 
XP_012817032  118 VDNCSSVLGGSTYNS     LLTIKVQ     TQQKTSI     FFFQ.[2].EQPADVLHANLEKAL.[4].LNK 174 
2CY4_A         79 IVRCDAVXPRGRSRS     LLLLVCQ.[2].ERAQPDV     HFFQ.[2].LLGAELIREDIQGAL.[4].SGR 137 
CAG06824      132 VLEVKAVLDSGPFNS     LLTVSVQ.[2].RRGSTSI     FVFQ.[1].DIRADLIQRDLSRAL     LNK 185  spotted green pufferfish

2LOZ_A        146      RK 147  human
AAI02415      179 .[1].MR 181 
Q9VHC3        714 .[1].LR 716  fruit fly
Q68CZ2       1442 .[1].KK 1444 human
Q0P4Q6        189 .[1].KK 191  tropical clawed frog
Q08509        192 .[1].KR 194  house mouse
XP_005168553  179 .[1].KK 181 
Q8TE68        163 .[1].ER 165  human
NP_001192218  155 .[1].QL 157 
XP_012817032  175 .[1].SK 177 
2CY4_A        138 .[1].ER 140 
CAG06824      186 .[1].KT 188  spotted green pufferfish
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