6ZYY,7KZN,6ZYW


Conserved Protein Domain Family
DHC_N1

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pfam08385: DHC_N1 
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Dynein heavy chain, N-terminal region 1
Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Statistics
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PSSM-Id: 462457
Aligned: 195 rows
Threshold Bit Score: 266.751
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

6ZYY_C    206 MQHYEMKFNEWINLISSQLNDDSEVRKD.[4].GPATELIYWRSRMQKITNWSEQLKSKDFQIVKASLQRHKN.[18].Y 296  Tetrahymena thermophil...
EGD73488  220 VKSLERVVLRWIKDIQQVTRLERDLSTG     SARQEIRFWLSMERALSQLKVRLAEDDVTLTLAVLREAKR      L 288 
EHY54023  279 LNSIQNHVIGWIKSIQGVTKLAKDGPST.[2].SAAQEINFWLSLESALNKLDDERHSDGVVLTLDILKKAKR      Q 349 
ERT02584  309 LNSLQATVNTWIKSIQVITKMTQDPSTG     TANQEINYWLSMESALERIETQLRGDGVSLTLDILKHAKR      F 377 
EOR01533  238 LNRLQNDVNSWIKEIRNVTKLNRDVASG     TASQEINFWLSMERALEGIEEQLKSEPIMLTLEILKYAKR      F 306 
Q5KFR9    285 LNKLQADVNSWIKEIQAVTKLNRDVASG     TASQEINFWTSMEHALEGIEQQLGGEEVTLVLDVLKHAKR      F 353  Cryptococcus neoformans
KDE03481  303 LNKLQSEVNSWIKEIQNVTKLSRDVASG     TASQEINFWLAMEKALESIEEQLRSDPIVLTLDILKTAKR      F 371 
EGU12573  274 LNKLQSEVNNWVKEVQKVTKLSRDVASG     TASQEVNFWLSMEKALEGIEKQLKSEPVQLSLDILKHAKR      F 342 
EPB90529  263 LNRLQSDVNGWIKEIQKVTKMSRDPASG     TAIQEINFWLSMERALEKIDEQLKSDQITLTLDILKHAKR      F 331 
EGF78727  194 LNKLQSDVNEWIKEIQKLTLLDRDPESG     SARQEIEFWIALERALNHIDLQLHSDEILLTLDTLRAAKR      F 262 

6ZYY_C    297 NRL     DLLLT.[1].KLNEAKDNVKYLTTL.[2].FIE.[2].Y.[2].TPQQIIDTLPALMNAI.[1].MIHTIA 353  Tetrahymena thermophila...
EGD73488  289 TIL.[5].DTNLS     MYDTVLDYNTLMKDF     PIN     A.[5].DIKKLVEAMLEVFQHM     KKVKHT 347 
EHY54023  350 QAV.[5].DTGLK.[1].ALETVRNYNTLMRDF     PLD     E.[5].SLGKVAEAIVLIFNHL.[1].KKWRVC 410 
ERT02584  378 QAT.[5].DTGLK.[1].AMERVQKYNQLMRDF     PLD     E.[5].TLAKVEDSIVQIFGHL.[1].KKLRIC 438 
EOR01533  307 HAT.[5].DTGLK.[1].ATDIVHKYNQLMKDF     PLD     E.[5].DFQKIQDSLYLIFGHI.[1].KKLKLS 367 
Q5KFR9    354 HAT.[5].DTGLK.[1].AADLVHKHNILMKDF     PLD     E.[5].DLEKIQDAIYLIFAHI.[1].KKLKLS 414  Cryptococcus neoformans
KDE03481  372 HAT.[5].DTGLR.[1].ATEIVTKYNQLMKDF     PLN     E.[5].DLAKVQDSLHMIFGHV.[1].KKLKLS 432 
EGU12573  343 HAT.[5].DTGLN.[1].AFKTVHDYNVLMKDF     PLN     E.[5].DLNKIKDSINQIFLHV.[1].KKLKLS 403 
EPB90529  332 HAT.[5].DTGLK.[1].GMELVHKYNQLMKDF     PLN     E.[5].DLDKIRESLHMIFGHL.[1].KKLKLS 392 
EGF78727  263 HAT.[5].DTGIK.[1].KTEKVQRYNQLMKDF     PIN     D.[5].DLDKIGESILLIFSHI.[1].KKFKIS 323 

6ZYY_C    354 .[1].FY.[2].TDKMTGLFIKITNQMIKNCKDRIL.[2].K.[11].IW.[2].D.[2].ELIEVLGSCIKLYCEYKKC 422  Tetrahymena thermophil...
EGD73488  348      RY.[1].RERFIELIKAISRDVNSQLLKILS     K.[ 2].LM.[4].P     EFENLYNQCNQLFREWNDK 403 
EHY54023  411      NY.[1].IRRALKLVEGISEDMNEQIHNLLR     G.[ 2].IM.[4].D     DFSELMRSVDLIWETWDDQ 466 
ERT02584  439      PY.[1].IRRALALVESISGDLDDAMHRLLP     G.[ 2].LV.[4].N     EFNRVMSAANGIFRAWDDV 494 
EOR01533  368      PY.[1].IRRALPLVEAISKDFNDQMLKVLQ     T.[ 2].LM.[4].E     SFERSINAADSAFKVWDDV 423 
Q5KFR9    415      PY.[1].IRRTLPLVEAISSDFNDQLLKVLS     S.[ 2].LM.[4].T     KFEEVMATAAEVFATWDEN 470  Cryptococcus neoformans
KDE03481  433      PY.[1].IRRALPLVEAISQDLNDQLLKVLG     S.[ 2].LA.[4].A     AFERSMSACSAVFHAWDEG 488 
EGU12573  404      PY.[1].VRRILPLVEAISRDLENQLHKVLS     S.[ 2].LT.[4].P     LFEQAMRAAEGVFQAWDES 459 
EPB90529  393      PY.[1].IRRALPLVEAISRDLNDQLLKVLG     S.[ 2].MM.[4].D     DFERTTAGAESVFHTWDDL 448 
EGF78727  324      PY.[1].IKRMLKLIEAISKDLNTQMLKTLS     S.[ 2].IM.[4].E     EFDFCIRKTDQVFRIWEEQ 379 

6ZYY_C    423 .[2].DTK.[12].DF     SD.[1].Q.[8].V      RRLQKLIEIFSNIQQF.[7].LEG      MDVLTN 486  Tetrahymena thermophila S...
EGD73488  404 .[5].IIQ      EL.[3].QR.[1].G     R.[14].ERLALVHDFRLRHDDL.[6].VLK.[13].LAEVEN 479 
EHY54023  467 .[6].VAR      EI.[1].RK.[1].N.[3].V.[12].ERLRYIAQFRHNHEQL.[6].VLG.[26].VEEVSA 555 
ERT02584  495 .[6].VAR      EV.[1].RR.[1].N.[3].I.[12].ARLKYIQNFRENHEQL.[6].VLG.[40].VEEVRQ 597 
EOR01533  424 .[6].VAR      EV.[1].RK.[1].S.[3].L.[12].ERCAYLRNFRKQHEQL.[1].NMT.[21].EDEVKA 502 
Q5KFR9    471 .[6].VAR      EV.[1].RK.[1].A.[3].I.[12].ERITYLRAFRRSHEQL.[1].VMT.[19].EEEVRL 547  Cryptococcus neoformans
KDE03481  489 .[6].VAR      DV.[1].RK.[1].N.[3].I.[12].ERVGYFRQFRKQHHQL.[1].VMV.[35].DAEVKL 581 
EGU12573  460 .[6].VAR      EV.[1].RK.[1].G.[3].I.[12].ERVLYFRHFRKQHHQL.[1].VMV.[41].EVEVRQ 558 
EPB90529  449 .[6].VAR      DV.[1].RK.[1].S.[3].L.[12].ERVAFVRAFRKQHEQL.[6].VMT.[32].VEEVKL 543 
EGF78727  380 .[6].VAR      EL.[1].RK.[1].S.[3].L.[12].ERLSFVHIFRRQHEDL.[6].VIK.[31].QEDVVS 473 

6ZYY_C    487 .[4].IIDDFK.[2].G.[1].NLLDTANNK     FDRDWVEFNVEISHLDGELQNFIDNNFNRF.[1].NIEY.[2]. 546  Tetrahymena thermophil...
EGD73488  480      AYDEMR     S.[1].DVLDLEEEG.[3].WDRACESYEARVNQVEDTIIKHLCHELDHA     AKSS      533 
EHY54023  556      AYEVVR     H.[1].DVLDVSTKG.[3].WIQAEKEYTERTSRVEDSIITRLRDRLGKA     KTAN      609 
ERT02584  598      AWEALR     N.[1].DLLDVTPEG.[3].WVRAENTYNERTARVENSIIARLRDRLATA     KNAN      651 
EOR01533  503      AYDTLK     N.[1].NVLDISVEG.[3].WIAAETAYNERVARVENQIIARLRDLLGTA     RNAS      556 
Q5KFR9    548      SYENVK     N.[1].NVLDVSPEG.[3].WYTAETAYNDRVARIENQIISRLRDKLATA     RNAQ      601  Cryptococcus neoformans
KDE03481  582      AYENVK     N.[1].DVLDVSSEG.[3].WVTAETSYNERVARVENQIIARLRDRLASA     RNAN      635 
EGU12573  559      AYEGIK     G.[1].DVLDVSDDG.[3].WIAAETGYNERVARVENHIISRLRDRLGGA     KNAN      612 
EPB90529  544      AYESVK     N.[1].DVLDVSPEG.[3].WVQAETAYNERVSRVENQIIARLRDRLGTA     KSAN      597 
EGF78727  474      AFDTIR     S.[1].NVLDLSPEG.[3].WVAAENIYTERIAQVEGQIISRLRDRLASA     RNAT      527 

6ZYY_C    547 KLLHKFQ     S.[2].KRDSLKHNLTSRYNAILHNYATELDTIQRVFQD.[1].KS.[2].P.[3].N     MPPEA 604  Tetrahymena thermophil...
EGD73488  534 DMFRIFR.[1].Y.[4].DRPRIRNAVRSYQKQLMSNVKDDIIELHKKFKM     QY.[7].M.[3].R.[1].IPPTS 599 
EHY54023  610 EMFRVFE.[1].F.[4].VRPKVRGAITAYQTQLLDNVKNAIASLHERFKQ     QY.[7].M.[3].R.[1].IPPVA 675 
ERT02584  652 EMFRVFS.[1].F.[4].VRPKIRGAIAEYQTQLIDNVKQAIAALHERFKQ     QY.[7].M.[3].H.[1].LPPVS 717 
EOR01533  557 EMFRVFG.[1].Y.[4].VRPKIRGAISEYQTQLIDSVKEDIKRLHGKFTT     QY.[7].M.[3].R.[1].IPPIA 622 
Q5KFR9    602 EMFRVFS.[1].F.[4].VRPKIRGAIQEYQTRLIESVKEDIHRLRQKFTE     NY.[7].M.[3].R.[1].FPSVS 667  Cryptococcus neoformans
KDE03481  636 EMFRVFS.[1].F.[4].VRPKIRGAIAEYQSELIDSVKEDIRALHDKFKR     SY.[7].M.[3].R.[1].HPPVS 701 
EGU12573  613 EMFRVFS.[1].F.[4].VRPKIRGAIAEYQSQLIDSVKDDIRRLQDKFKS     GY.[7].M.[3].R.[1].HPPIS 678 
EPB90529  598 EMFRVFS.[1].F.[4].VRPKIRGAIQEYQTQLIDSVKEDINKLHDKFKM     QY.[7].M.[3].R.[1].LPPIS 663 
EGF78727  528 DMFRVFS.[1].F.[4].IRPKIRGAIHEYQTQLIERVKEDIHRLHEKFAA     QH.[7].M.[3].R.[1].LMPIS 593 

6ZYY_C    605 GKIIWARHLFQKITGPINIFPE.[ 8].RRYYGSYNTLGKQLT.[2].EMWFYQDWVNK.[1].E.[4].A     LQA 672  Tetrahymena thermophila...
EGD73488  600 GQIIWMAQIERQLDDYLERVGH.[12].RELKERGETFKEKLR     QANPYDLWLQE.[1].E.[1].Q.[4].KNT 670 
EHY54023  676 GAILWVRQIETQLDNYMSKVHA.[12].EKLQIESNMFRKKLS     TREIYQAWVQD     V     Q.[6].SGR 746 
ERT02584  718 GAIIWARQIERQLDNYMKKVED.[12].QKLQNESIQFRKKLK     TAPIFEAWARD     T     M.[6].AGR 788 
EOR01533  623 GAIIWAKQIERQLNMYMKRVED.[12].AKLQSESTSFRKKLD     TRPIFEAWLHE     I     N.[6].EGR 693 
Q5KFR9    668 SAIIWARQIERQLLTYMKRVED.[12].HKLQMESASFRTKLD     TRPLYDAWISD     I     T.[7].TGR 739  Cryptococcus neoformans
KDE03481  702 GAIVWAKQIERQLLAYMKRVED.[12].TKLQAESQSFRRKLD     TRPIYDAWLHD     I     Q.[6].TGR 772 
EGU12573  679 GAIIWARQIERQLSGYMKRVED.[12].QRLQTESQSFRAKLS     TRPIYDAWLVD     I     N.[6].SGR 749 
EPB90529  664 GAIIWARQIDRQLSLYMKRVED.[12].QKLQIESSSFRKKLD     TRLIYENWLQE     I     T.[6].SGR 734 
EGF78727  594 SSVIWARQIERQLGEYMKRVED.[12].QKLSQEERAFKNQLN     TRPIFDRWVAN     I     S.[6].GGR 664 

6ZYY_C    673 .[1].LIVR.[3].N.[ 4].VNFDLEIMQLIREAKCLDRQG.[2].IPESARIILLQEDKFKTYYNELLYALKEYERIN 741  Tetrahymena thermophil...
EGD73488  671      IFDI.[2].F.[10].VNFHERLITMAKEVRIMGWLK.[4].VPKLAVVKAKKANMLYPYVISLKNSIKTYSIAM 745 
EHY54023  747      LFAI.[2].S.[10].VNFDNHAISLFKEVRNLTWLN.[2].VPHRITTTAKQAQRVYPYALSLMESVAGYFSAV 819 
ERT02584  789      LFSI.[2].V.[10].VNFDPQVIALFKETRNLIWLN.[2].VPHAVNSVAKDAKRVYPYAVSLMESVRTFAQTL 861 
EOR01533  694      LFEI.[2].T.[14].VNFDPQVITLFKEVRNLLWRQ.[2].VPHAIINIAKDAKRVYPHAVSLMETVRTYSLTV 770 
Q5KFR9    740      LFDV.[2].T.[14].VQFDPQVIALFKEVRSLIWLG.[2].VPLTISHKAKDAKRVYPHAVSLMESVKTYTQTL 816  Cryptococcus neoformans
KDE03481  773      LFDI.[2].S.[10].VNFDAQIITLFKEVRNLVWLG.[2].VPHTISNIAKDAKRVYPHAVSLMETVRTYSQTI 845 
EGU12573  750      LFNI.[2].S.[10].VNFDPQIITLFKEVRNLLWLG.[2].VPHTISNVAKDAKRVYPYAVSLMETVRTYSQTV 822 
EPB90529  735      IFEI.[2].N.[10].VNFDGQIITLFKEVRNLLWLN.[2].VPHTISNVAKDAKRVYPFAVSLMETVRTFSQTV 807 
EGF78727  665      IFDI.[2].N.[10].VNFDDQIIAVFKEIRNLLWHQ.[2].VPHPIVNVAKDAKRVYPFAVSLAETVRTWDKTL 737 

6ZYY_C    742 SKI.[3].CK     NLLLPHIEDLDLKLRPGMV.[1].LTWTSM.[1].IESY 780  Tetrahymena thermophila SB210
EGD73488  746 NQL     DD.[5].PLVARWYNRVHDQIAYGMD     LTWESP     LEAY 784 
EHY54023  820 RAI     QE.[5].PLMASYEKEVQNLFATGVR     LRWESF     INSY 858 
ERT02584  862 RTI     NE.[5].MLLNGHRNDVYALIAKGVP     LRWESF     VNSY 900 
EOR01533  771 ERI     TA.[5].PLIAEYRIEAQNIITKGMP     LRWEFF     VNTY 809 
Q5KFR9    817 ELI     ES.[5].ILLASYRSHALQMIERGIK     MQWDHL     VNAY 855  Cryptococcus neoformans
KDE03481  846 AKL     QA.[5].ALVAEFRTNAQQQITKGMN     VRWEHV     VNSF 884 
EGU12573  823 AKL     EA.[5].SLVATSHKKAQEQIAKGMS     YRWDHF     VNTF 861 
EPB90529  808 HKV     NR.[5].TLVAESRHEVHNMITKGIN     LRWDYF     VNTY 846 
EGF78727  738 NLL     SQ.[5].WLVATYHKSVQTLISKGIQ     LRWDYF     INTY 776 
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