2F4W


Conserved Protein Domain Family
UBCc_UBE2J

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cd23799: UBCc_UBE2J 
Click on image for an interactive view with Cn3D
Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 J1, J2 and related proteins
The E2J subfamily includes mammalian ubiquitin-conjugating enzymes E2 J1 (UBE2J1/HSPC153/HSPC205/NCUBE1) and J2 (UBE2J2/NCUBE1), yeast ubiquitin-conjugating enzyme E2 6 (UBC6/DOA2), and plant ubiquitin-conjugating enzyme E2 32-34 (UBC32-34). They are ubiquitin-conjugating enzymes (EC 2.3.2.23) that accept ubiquitin from the E1 complex and catalyze the covalent attachment to other proteins. UBE2J1 and UBE2J2 are non-canonical ubiquitin-conjugating enzyme (NCUBE), which function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Saccharomyces cerevisiae UBC6 functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. It is a cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.
Statistics
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PSSM-Id: 467419
Aligned: 136 rows
Threshold Bit Score: 155.706
Created: 16-Aug-2017
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: active site cysteine [active site], 1 residue position
Conserved feature residue pattern:CClick to see conserved feature residue pattern help
Evidence:
  • Comment:forms a thioester with ubiquitin or ubiquitin-like proteins
  • Comment:serves as the point of attachment of ubiquitin prior to transfer to cellular target
  • Citation:PMID 9497353
  • Citation:PMID 9705497

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                        
2F4W_A        17 QRLKQDYLRIKK.[4].YICAEPLP.[3].LEWHYVVRGP.[6].GGYYHGKLIFP.[2].FPFKPPSIYMITPNGRFKC 91  human
TNJ30576      29 RMLAQEKRDPDP.[1].YQIFLPDP.[3].LEIHFSVHGP.[6].GGIYHGLIMLD.[2].HPFKPPHIQMLTPSGRFET 100 Giardia muris
XP_001707570  19 RKLLWEQKNPDP     YYKLRLTN.[4].YRIHFSCRGP.[6].GGIYHGVLVLP.[2].FPFKPPDLMMITPSGRFEI 90  Giardia intestinalis
XP_001705543  13 RHILKELRKTTP.[3].LFMLKNND.[1].LELHFSVAGP.[6].NGIYHGRILLD.[2].HPTKPPNIQMITPSGRFET 84  Giardia intestinalis
EES98853       6 RRISHELKLISL.[4].YFKVYLDP.[3].LNVHFTFLGP.[6].KGLYHGVIHLP.[2].YPHKPPEIVFLTNSGRFET 80  Giardia intestinalis...
Q5UQ57         6 KRVIKDINDGMK.[6].GIYLAPEE.[3].YKVHFILQGP.[6].GGLYHGMIRLN.[2].HPFRPPNLHMITPSGRFEA 82  Acanthamoeba polypha...
YP_009001634   5 QRIMKEISNLQN.[5].IIINIGDT.[1].NIIHFILIGY.[6].NGYYYCKLFLN.[1].YPVTAPDIMMITPNGLFKP 77  Anomala cuprea entom...
KAH0574403     5 IRIKSELKNLIL.[4].FFKVYFDP.[3].YNIHFSVLGP.[6].KGIYHGVIFLP.[2].YPFSAPDIQFYNNNGRFEV 79  Spironucleus salmoni...
XP_024508798  11 LRIMKEIRELMN.[5].IFKIHVNE.[3].FDIHFTFIGK.[5].NGLYHGRMILP.[2].YPMRPPDFWMISESGRFQT 85  Strongyloides ratti
KAH0575521     9 KIIMRQLKAVQQ.[5].YKIWIPDK.[3].LDIHFSVRGP.[6].GGAYHGQLLLP.[2].YPFRAPHVRMITPSGRFET 84  Spironucleus salmoni...

Feature 1                #                                                    
2F4W_A        92 .[1].TRLCLSITDF.[4].WNPAWSVSTILTGLLSFMVEKG.[ 8].SDFTKRQLAVQSL 149 human
TNJ30576     101 .[1].KNICFSFTAY.[4].WSPACKLRDIIIGLSSMFDATK.[10].NPSDVVECREKSR 160 Giardia muris
XP_001707570  91 .[1].KKICFSYTSY.[4].WSPALNFKHIIIGFLSLFNEYS.[12].PTIDRYKEANMKF 152 Giardia intestinalis
XP_001705543  85 .[1].RNICFSYTSF.[4].WSPIITFTDIIVGFTSLFSDEA.[10].DKIAAKQYASDSR 144 Giardia intestinalis
EES98853      81 .[1].KYICTSFTSF.[4].WNPTWGIRNIIIGLRSLFDEET.[ 9].SPEVREKYALDSH 139 Giardia intestinalis ATCC 50581
Q5UQ57        83 .[9].RGICTTATSF.[4].WTSMNNLETVLKGFVSLMCDPY.[ 9].TDTQVKKLAQDSL 149 Acanthamoeba polyphaga mimivirus
YP_009001634  78 .[1].TKLCIDGLTS.[5].WAITTKLDKILIAFQSFMNDTI.[10].TITEKKILSKSSI 138 Anomala cuprea entomopoxvirus
KAH0574403    80 .[1].KNICTNFTSF.[4].WSATWGIRQVIIGLRSMFDEET.[ 9].SEEQRKIFAEQSI 138 Spironucleus salmonicida
XP_024508798  86 .[1].TKICMSNTSF.[4].WSPSWGIRTAILGLISLFYEES.[ 9].NKNVRKRYAMYSS 144 Strongyloides ratti
KAH0575521    85 .[1].TNICFSFTAF.[4].WSPAVGFGPIIIGLQSLFQEYK.[10].SQSEIKKCVETSQ 144 Spironucleus salmonicida

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