1CHC


Conserved Protein Domain Family
RING-HC_EHV1-like

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cd23130: RING-HC_EHV1-like 
Click on image for an interactive view with Cn3D
RING finger, HC subclass, found in Equid alphaherpesvirus 1 (Equine herpesvirus 1/EHV-1) regulatory protein and similar proteins
EHV-1 regulatory protein belongs to the Vmw110 (IPC0) protein family. It contains a typical C3HC4-type RING-HC finger and binds zinc stably.
Statistics
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PSSM-Id: 438492
Aligned: 14 rows
Threshold Bit Score: 75.4671
Created: 11-Jun-2021
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
Zn binding site
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Structure:1CHC; Equid alphaherpesvirus 1 RING domain binds two Zn2+ ions
    View structure with Cn3D
  • Citation:PMID 8263911
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1           #  #               # #  #  #              #  #          
1CHC_A          6 ERCPICLED.[2].NYSMALPCLHAFCYVCITRWIRQN.[1].TCPLCKVPVESVVHT 56   Equine herpesvirus 1
XP_001312900  220 FQCPVCLEN.[1].KFYITLPCSHSFCLTCFLRWGAQV.[1].NCPMCRHKFTSWIHQ 269  Trichomonas vaginalis G3
OPJ77464        7 NRCPICLDS.[2].EASYVMPCLHQFCYACILRWAQSK.[1].ECPLCKRRILSILHS 57   Patagioenas fasciata monilis
EPR61557     1486 DICAICTED.[4].DEIGTLACMHQFCFTCISRWGGIR.[1].YCPLCKQEFREISRH 1538 Toxoplasma gondii GT1
PKK21232        5 WSCPICQVP.[2].DIASALPCRHQFCLGCILRWTERK.[1].NCPLCRRPIDTVRFS 55   rock pigeon
XP_009174239  274 DECVICLDP.[2].NRSIVLPCMHTFCFECIYRWLCIN.[1].SCPLCKRLAHRIIHS 324  Opisthorchis viverrini
Q9E1W2         17 GNCAICMSA.[2].GLGKTLPCLHDFCFVCIQTWTSTS.[1].QCPLCRTVVSSILHN 67   Cercopithecine herpesvirus 9 (strain DHV)
ORY42384       37 EPCPICLDT.[2].ATTCLVPCLHSFCLTCISTWAQSS.[1].LCPLCKTVFGEGRHA 87   Rhizoclosmatium globosum
XP_004365935  121 NVCAICLED.[4].SKAQLPPCLHEFCIRCVLTWSTVR.[1].CCPLCKTEFSHVSTH 173  Capsaspora owczarzaki ATCC 30864
OHT01781      231 DNCAICLSE.[1].IEPIELPCGHIHCYDCTYKWLKTS.[1].TCPTCRSAVYGTKLM 280 

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