Conserved Protein Domain Family
PDZ_GIPC3
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cd23079: PDZ_GIPC3 
PDZ domain of PDZ domain-containing protein GIPC3, and related domains
PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of GIPC3, and related domains. GIPC3 (also known as C19orf64) belongs to the GIPC family, members of which contain an N-terminal GIPC-homology 1 (GH1) domain, a central PDZ domain, and a C-terminal GH2 domain. GIPC proteins function as adaptor molecules that assemble RTKs, GPCRs, integrins, transmembrane proteins and cytoplasmic signaling regulators as cargoes of MYO6-dependent endocytic transport. Mutations in the Gipc3 gene cause nonsyndromic hearing loss. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This GIPC3 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.
Links
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Statistics
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PSSM-Id: 467292
Aligned: 7 rows
Threshold Bit Score: 176.648
Created: 14-Sep-2020
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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peptide binding
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on canonical PDZ domains with structure
  • Comment:PDZ domains specifically recognize and bind to short C-terminal peptide motifs, but can also recognize internal peptide motifs and certain lipids
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                      #######         #  #                             #   #  ##    
Q8TF64       107 RGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPK 182 human
NP_683753     92 RGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPK 167 Mus musculus
KAF6093961   107 RGETKEVEVTKTEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAKMLRELPK 182 Phyllostomus discolor
NP_001038783 129 RGETKEVEVIKTEDALGLTITDNGAGYAFIKRIKEGSTIDRIKSVCVGDHIEAINDQSIVGCRHYEVAKMLKEQPR 204 zebrafish
XP_005999139 166 RGETKEVEVVKTEDALGLTITDNGTGYAFIKRIKEGSIIDKIKTVCVGDHIEAINDQSIVGCRHYEVAKMLKELPR 241 coelacanth
XP_018099017 136 RGETKEVEITKTEDALGLTITDNGAGYAFIKRIKEGSITDRLKIVNVGDIIESINDQTIVGCRHYEVAKMLRELPK 211 African clawed frog
XP_007896907  34 RGQLKEVEVTKSEDALGLTITDNGTGYAFIKRIKEGSTIDRIKMVCVGDHIEAINNRSMVGCRHYEVAKMLKDLPK 109 elephant shark


Feature 1                         
Q8TF64       183 .[1].QPFTLRLVQPKR 195 human
NP_683753    168 .[1].QPFTLRLVQPRR 180 Mus musculus
KAF6093961   183 .[1].QPFTLRLVQPKR 195 Phyllostomus discolor
NP_001038783 205 .[1].TPFTLRLVEPKK 217 zebrafish
XP_005999139 242 .[1].ESFTLRLVEPKK 254 coelacanth
XP_018099017 212 .[1].ETFTLRLVHPKR 224 African clawed frog
XP_007896907 110 .[1].QPFALGLVEPRK 122 elephant shark

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