4EGX,4EJQ


Conserved Protein Domain Family
FHA_KIF1A
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cd22726: FHA_KIF1A 
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forkhead associated (FHA) domain found in kinesin-like protein KIF1A
KIF1A, also called axonal transporter of synaptic vesicles (ATSV), microtubule-based motor KIF1A, Unc-104- and KIF1A-related protein, or Unc-104, is an axonal transporter of synaptic vesicles, which is mutated in hereditary sensory and autonomic neuropathy type 2. It is also required for neuronal dense core vesicle (DCV) transport to dendritic spines and axons. The calcium-dependent interaction with CALM1 increases vesicle motility, and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites. The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.
Links
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Statistics
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PSSM-Id: 438778
Aligned: 8 rows
Threshold Bit Score: 247.534
Created: 4-Sep-2020
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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homodimer
Conserved site includes 22 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:4EGX; Homo sapiens Kif1a forms a homodimer through its FHA domain, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                ## ## ####### ## ##           ## #                                       
4EGX_A         68 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].RRQDIVLSGHFIKEEHCVFRSDS.[5].AVVTLEPCEGADTYV 144  human
4EJQ_A         38 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].RRQDIVLSGHFIKEEHCVFRSDS.[5].AVVTLEPCEGADTYV 114  human
Q12756        491 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].RRQDIVLSGHFIKEEHCVFRSDS.[5].AVVTLEPCEGADTYV 567  human
XP_002662484  491 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].SRQDIVLSGHFIKEEHCTFTSTT.[4].EAVILEPCEGAETYV 566  zebrafish
XP_007905522  517 TPHLVNLNEDPLMSECLLYYIKDGFTRVGRED.[2].RRQDIVLSGHFIKEEHCIFRSNA.[5].VVVILEPCEEADTYV 593  elephant shark
XP_014344552  491 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].KRQDIVLSGHFIKEEHCIFRSET.[5].AVVKLEPCEEADTYV 567  coelacanth
XP_015132578  546 TPHLVNLNEDPLMSECLLYYIKDGITRVGRED.[2].KRQDIVLSGHFIKEEHCLFRSDT.[5].VIVTLEPCEGADTYV 622  chicken
XP_018119359  491 TPHLVNLNEDPLMSECLLYYIKDGITRVGREH.[2].LRQDIVLSGHFIRDEHCIFRSDI.[5].VVVTLEPCDGADTYV 567  African clawed frog


Feature 1                                  # # #   #    
4EGX_A        145 NGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERE 182  human
4EJQ_A        115 NGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERE 152  human
Q12756        568 NGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERE 605  human
XP_002662484  567 NGKRVTEPTVLKSGNRIILGKSHVFRFNHPEQARQERD 604  zebrafish
XP_007905522  594 NGKKVSEPTILRSGNRIIMGKSHVFRFNHPEQARQERD 631  elephant shark
XP_014344552  568 NGKKVTEPIILRSGNRIIMGKNHVFRFNHPEQARQERE 605  coelacanth
XP_015132578  623 NGKKVTEPSVLRSGNRIIMGKSHVFRFNHPEQARQERE 660  chicken
XP_018119359  568 NGKKLTESCTLRSGNRIIMGKSHVFRFTHPEQARQERE 605  African clawed frog

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