Conserved Protein Domain Family
PPP1R42

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cd21340: PPP1R42, with user query added  
protein phosphatase 1 regulatory subunit 42
Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Statistics
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PSSM-Id: 411060
Aligned: 99 rows
Threshold Bit Score: 185.375
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

query         878 HLHLSGNCYL.[3].ALN     LDGQHLFEITNL.[3].ENLKWASFSNNNLTKMEGLESCINLEELT.[3].NCISKI 946 
Q7Z4L9         32 HINFSDKNID.[3].DLS.[9].LYDNCISQITNL.[3].TNLTHLYLQNNCISCIENLRSLKKLEKLY.[3].NYIAVI 109  Homo sapiens
XP_002601655   33 HLYFQERHID.[3].DLS.[9].LYDNRIARIQNL.[3].SNLTHLYLQNNLINKIENLSLLRRLEKLY.[3].NEITVV 110  Branchiostoma flor...
XP_006006857   33 HLNFSDKNIN.[3].DLS.[9].LYDNHITEIRNL.[3].SNLTHLYLQNNSISHMENLSSLQNLCKLY.[3].NCITVV 110  Latimeria chalumnae
KFV70074       32 HLNLSDKNID.[3].DFS.[9].LYDNHIRQIQNL.[3].SNMTHLYLQNNCIAAMDNLSSLKNLEKLY.[3].NCIAVV 109  Downy woodpecker
XP_023933628   34 HLYLEDRNID.[4].DLA.[9].LYDNKLPKVPVL.[3].QNLTHLYLQNNHITRMENLAPLRRLTKLY.[3].NSITVV 112  Lingula anatina
XP_007885028   33 HLNFSDKNID.[3].DLS.[9].LYDNSIKEIRNL.[3].SNLTHLYLQNNNISHIENLSLLEKLTKLY.[3].NRISVV 110  Callorhinchus milii
NP_001088790   33 HLNFSNKNID.[3].DLT.[9].LYDNNINQIKNL.[1].SNLTHLYLQNNCISCIENLSGLKRLEKLY.[3].NCLTVV 108  Xenopus laevis
RNA35562       44 HLYLQEKSID.[3].SIP.[9].LYDNYIEKMEHL.[3].PKLEHLYLQNNQIKRLENLNTLTKLTKLY.[3].NCIKVL 121  Brachionus plicatilis

query         947 EGIS.[4].LTRLSINNNLLT.[1].WEEHTFDNM.[1].HLHSLSLENNRI.[5].LQKSFTLVELYISNNYI.[3].Q 1015
Q7Z4L9        110 EGLE.[4].LRELHVENQRLP.[1].GEKLLFDPR.[7].SLCILNISNNNI.[5].LELLENLNQLIAVDNQL     L 181  Homo sapiens
XP_002601655  111 EGLD.[4].LKELHIENQRLP.[1].GEKLLFDPR.[7].TLCVLNVSGNNL.[5].FRCLGQLNQFMAADNQL     E 182  Branchiostoma flor...
XP_006006857  111 EGLE.[4].LQELHIECQRLP.[1].GEKILFDPR.[7].SLSVLNVSNNNI.[5].LAILENITQFTAGYNQL     K 182  Latimeria chalumnae
KFV70074      110 EGLD.[4].IRELHIESQRLP.[1].GEKLVFDPR.[7].SLTVLNISNNNI.[5].LAVLENLSYLTAADNQL     R 181  Downy woodpecker
XP_023933628  113 EGLE.[4].LQEFHIENQNLP.[1].GEKLLFDPR.[7].CLQVLNVSGNNL.[5].LECLRELTQIMANDNNL     N 184  Lingula anatina
XP_007885028  111 EELD.[4].LRELHLENQQLP.[1].GEKLLFDPR.[7].SLSLLNVKKNNI.[5].LSCLKNLNQLMAGENQI     Q 182  Callorhinchus milii
NP_001088790  109 EGLE.[4].LRELHIENQRLP.[1].GEKLLFDPR.[7].SLSVLNISNNNI.[5].LAVLENLTQFVAADNQL     K 180  Xenopus laevis
RNA35562      122 EGLE.[4].LNELQIENQELP.[1].GEKLMFDPR.[7].SLTILNISANNL.[5].IGSLKNLQDLNASNNYL     N 193  Brachionus plicatilis

query        1016 EMHN.[ 6].LVILDMCGNIII.[3].ENYRLFVI.[5].LKALDGIPI.[2].SE 1066
Q7Z4L9        182 HVKD.[10].LWKIDLNGNPVC.[2].PKYRDRLI.[5].LEFLDGKEI.[2].IE 235  Homo sapiens
XP_002601655  183 DMKE.[10].LWRLELVGNPLC.[2].AKYRDRVI.[5].LEVLDGKEI.[2].TA 236  Branchiostoma floridae
XP_006006857  183 DIED.[10].LWRMDLSKNPVC.[2].PKYRDRII.[5].LTILDGKEI.[2].TA 236  Latimeria chalumnae
KFV70074      182 SMKD.[10].LCRMDLTGNPIC.[2].PKYRDRIV.[5].LESLDGKEI.[2].VE 235  Downy woodpecker
XP_023933628  185 DMRE.[10].LWRLELIGNPMC.[2].SKYRDRVI.[5].LEILDGKEI.[2].NA 238  Lingula anatina
XP_007885028  183 DLKE.[10].LWYLDLTGNPVC.[2].PKYRDKVI.[5].LEVLDEKEV.[2].TA 236  Callorhinchus milii
NP_001088790  181 EIKD.[10].LCRMDLSGNPVC.[2].PKYREKVT.[5].LEILDGKEI.[2].MA 234  Xenopus laevis
RNA35562      194 DMKE.[10].LTTLNLSGNPIC.[2].NKYRERII.[5].IEVLDEKEI.[2].LS 247  Brachionus plicatilis
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