Conserved Protein Domain Family
C1_RASGRP4
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cd20863: C1_RASGRP4 
protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 4 (RASGRP4) and similar proteins
RASGRP4 functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. It may function in mast cell differentiation. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410413
Aligned: 6 rows
Threshold Bit Score: 120.653
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens RASGRP1 binds two Zn2+ ions
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1           #            #  #                 #  #    #  #          #    
Q8TDF6       538 AFLHTFHEVTFRKPTFCDSCSGFLWGV.[1].KQGYRCRECGLCCHKHCRDQV.[2].ECKKRP 594 human
NP_001038327 534 HNLHNFHETTYKRPTFCDTCGGFLWGV.[1].KQGYHCKDCGVNCHKHCKDVV.[2].ECLKRL 590 zebrafish
XP_005987939 542 GFPHNFQETTYKKPTFCYICTGFFWGV.[1].KQGYRCQGCGINCHKHCMDQV.[2].ECKKRF 598 coelacanth
TFJ99426     576 GFLHDFQEATFKKPTFCHSCNGFLWGV.[1].KQGYRCRDCGRSCHKQCKALV.[2].ECKKRF 632 big-headed turtle
XP_007909266 402 GQRHSFQENTFMRPTFCDMCTGFLWGV.[1].KQGYRCQDCGINCHKQCVEQV.[2].ECKKRT 458 elephant shark
KYO30139      24 APQHHFHTAAFKKPTLCHCCSGLLWGV.[1].KQGYRCQDCGMSCHKQCKELV.[2].ECKRRP 80  American alligator

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