Conserved Protein Domain Family
C1_RASGRP3
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cd20862: C1_RASGRP3 
protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
RASGRP3, also called calcium and DAG-regulated guanine nucleotide exchange factor III (CalDAG-GEFIII), or guanine nucleotide exchange factor for Rap1, is a guanine nucleotide-exchange factor activating H-Ras, R-Ras and Ras-associated protein-1/2. It functions as an important mediator of signaling downstream from receptor coupled phosphoinositide turnover in B and T cells. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites.
Links
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Statistics
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PSSM-Id: 410412
Aligned: 6 rows
Threshold Bit Score: 130.539
Created: 7-Oct-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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Zn binding siteputative DAG/PE
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:H C C C C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:Two non-consecutive sets of zinc-binding residues form two separate metal-binding sites.
  • Comment:Based on the structure evidence that Homo sapiens RASGRP1 binds two Zn2+ ions
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1               #            #  #             #  #    #  #       #  
Q8IV61       488 KMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACRR 546 human
NP_001103934 488 KMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRELLVLACRR 546 zebrafish
NP_001006401 487 KMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCRDLLVLACRK 545 chicken
XP_007896633 489 KMGPGFIHNFQEITYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCRDLLVLACRK 547 elephant shark
XP_005992876 488 KMGPGFIHNFQEMNYLKPTFCEHCAGFLWGIIKQGYKCKDCGVNCHKQCKDLLVLACRK 546 coelacanth
OCT79916     487 KLGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGFKCKDCGANCHKQCKDLLVLACRK 545 African clawed frog

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