Conserved Protein Domain Family
Tudor_TDRD6_rpt6
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cd20425: Tudor_TDRD6_rpt6 
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins
TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
Links
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Statistics
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PSSM-Id: 410496
Aligned: 5 rows
Threshold Bit Score: 189.976
Created: 11-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative
Feature 1:putative peptide binding site [polypeptide binding site]
Evidence:
  • Comment:based on the structures of other Tudor-like family proteins with bound methylated/dimethylated peptides
  • Comment:In general, the Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                                                                     #          #       
O60522       1306 KTTVYVSHINDL.[1].DFYVQLIEDE.[5].LSERLNSVKTRPE.[ 7].QRGDMICAVF.[1].EDNLWYRAVIKEQ 1377 human
KFW94604     1253 KVLVYVSHVNNP.[1].DFYVQLESDE.[5].ISECLNNRTQAKN.[ 6].QAGDLICAVY.[1].EDSLWYRAVVKEK 1323 great cormorant
BAD51732     1369 KSSVYVAHTNTI.[1].DFYVHIAQNT.[4].ISEILNNEKGPSD.[ 7].NLGDLICAFY     EDGLYYRAVITEK 1438 African clawed frog
XP_014348589 1327 KTQVYISHINSP.[1].CFFVQLAKDE.[5].LAEKLNAGGLITE.[ 7].QVGNLVCAEF.[1].DDGCAYRAVVKEK 1398 coelacanth
XP_007895293 1416 KCEARISHVVSP.[1].HFFVHLSQHD.[5].MEEKLNASWANDT.[10].QLGDMVCAES.[1].EDGSHYRSVVTQK 1490 elephant shark


Feature 1                    #  # #                              
O60522       1378 .[3].DLLSVQFIDYGNVSVV.[3].KIGRLDLVNAILPGLCIHCSL 1420 human
KFW94604     1324 .[3].NLISIQYIDYGNTSVI.[3].QADRLPENLLSIPAISIHCFL 1366 great cormorant
BAD51732     1439 .[2].DGLLAQYIDYGNTSVI.[3].KIYKLPPSLLSIPAMSICCAL 1480 African clawed frog
XP_014348589 1399 .[3].GMVHVEFIDYGNTTTV.[3].KLLKLEQEFLSIPKLSIMCSL 1441 coelacanth
XP_007895293 1491 .[3].NLVGVEFIDYGNTVNV.[3].KIHRLSKEAMEVQRLSVPCFI 1533 elephant shark

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