CDD Conserved Protein Domain Family: Tudor

cd20386: Tudor_PHF20-like

Tudor domain found in PHD finger protein 20 (PHF20), PHF20-like protein 1 (PHF20L1), and similar proteins

PHF20, also called Glioma-expressed antigen 2, hepatocellular carcinoma-associated antigen 58, novel zinc finger protein, or transcription factor TZP (referring to Tudor and zinc finger domain containing protein), is a regulator of NF-kappaB activation by disrupting recruitment of PP2A to p65. It also functions as a transcription factor that binds to Akt and plays a role in Akt cell survival/growth signaling. Moreover, it transcriptionally regulates p53. The phosphorylation of PHF20 on Ser291 mediated by protein kinase B (PKB) is essential in tumorigenesis via the regulation of p53-mediated signaling. PHF20L1 is an active malignant brain tumor (MBT) domain-containing protein that binds to monomethylated lysine 142 on DNA (cytosine-5) Methyltransferase 1 (DNMT1) (DNMT1K142me1) and colocalizes at the perinucleolar space in a SET7-dependent manner. Both PHF20 and PHF20L1 contain an N-terminal malignant brain tumor (MBT) domain, a Tudor domain, a plant homeodomain (PHD) finger and putative DNA-binding domains AT hook and C2H2-type zinc finger. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

2EQU_A 10 FKAGEEVLARW.[1].DCRYYPAKIEAI.[2].EGTFTVQFYDGVIRCLKR.[1].HIKAM 59 human FAA00196 958 FMKGETVLAKW.[1].DCRLYFAKILQC.[2].EDTYKIRYFDGHVKIVKE.[1].FLRPY 1007 Ciona intestinalis AAD38875 212 FEEGEDVLARW.[1].DGNFYPATVVKV.[2].TGSCVVMYFDGMKKLIRK.[1].VMKKM 261 Molgula oculata FAA00196 1093 YRAGEQVLCRW.[1].DRKFYPATVIKQ.[2].LDHYLIKYFDNRKKVVKH.[1].WLSPW 1142 Ciona intestinalis XP_017464006 15 FQVDEEVLAKW.[1].DSKFYPATIIEI.[1].NDFCKVLFEDGYQKKVKL.[1].ALKKI 63 snowberry fruit fly OTF72582 27 FDLNEEILARW.[1].DQQFYPARITTF.[3].GQYCQVLFYDGYRKKVKV.[1].SLRKM 77 Euroglyphus maynei EFX82597 108 FKVGEKVMAVW.[1].NNKRYPAQITKV.[2].PGNFEVIFYDGFSMQVKA.[1].QMSRM 157 common water flea XP_004348170 702 FSAHQRVMARW.[1].DRKLYPATIRQV.[2].GGSCDILFDDGFNKLASP.[1].SMRHM 751 Capsaspora owczarzaki ATCC 30864 NP_731688 288 FELDEKCMARW.[1].GPRKFPGTIRKL.[2].NDTYEVLFDDGYVKNVRA.[1].HMNKM 337 fruit fly OWR46297 325 FVVGERCLARW.[1].DNRRFIATILTD.[2].NGNYEIMFDDGFKWKCTT.[1].RMCKL 374 Danaus plexippus plexippus

2EQU,2LDM

Conserved Protein Domain Family
Tudor_PHF20-like

2EQU,2LDM

Conserved Protein Domain FamilyTudor_PHF20-like

Conserved Protein Domain Family
Tudor_PHF20-like