5DV7


Conserved Protein Domain Family
DSRM_ILF3_rpt1
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cd19910: DSRM_ILF3_rpt1 
first double-stranded RNA binding motif of interleukin enhancer-binding factor 3 (ILF3) and similar proteins
ILF3 (also known as double-stranded RNA-binding protein 76 (DRBP76), M-phase phosphoprotein 4 (MPP4), nuclear factor associated with dsRNA (NFAR), nuclear factor of activated T-cells 90 kDa (NF-AT-90), or translational control protein 80 (TCP80)) is an RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. ILF3 contains an N-terminal DZF domain and two double-stranded RNA binding motifs (DSRMs). This model describes the first motif. DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.
Links
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Statistics
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PSSM-Id: 380739
Aligned: 8 rows
Threshold Bit Score: 147.594
Created: 24-Oct-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
RNA binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:RNA binding site [nucleic acid binding site]
Evidence:
  • Comment:Based on structure evidence that Rattus norvegicus RED1 (2L3J) binds dsRNA.
  • Structure:5DV7; Mus musculus ILF3 binds dsRNA, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1              #  ##  ## #             ## # #                ###  #                
5DV7_C        395 DPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSNFEASGPSKKTAKLHVAVKVLQDMGLPTG 467  house mouse
Q6NXA4        402 EPAQAMNALMRLNQLKPGLQYKLISQTGPVHVPVFTMSVEVDGKNFEASGPSKRTAKLHVAVKVLQDMGLPTG 474  zebrafish
XP_005994194  496 EPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPVFTMSVEVDGKTFEASGPSKKTAKLHVAVKVLQDMGLPTG 568  coelacanth
Q12906        398 EPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTG 470  human
AFK84018      398 EPPQAMNALMKLNQLKPGLQYKLVSQTGPVHAPIFTMSVEIDGSTFEASGPSKKTAKLHVAVKVLQDMGLPTG 470  chicken
Q6DD04        399 EPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDDKTFEASGPSKKTAKLHVAVKVLQDMGLPTG 471  African clawed frog
Q91550        399 EPPQVMNALMRLNQLKPGLQYKLISQTGPVHAPVFTMSVEVDDKTFEASGPSKKTAKLHVAVKVLQDMGLPTG 471  African clawed frog
XP_007909112  412 EPVQAMNALMRLNQLRPGLQYKLISQTGPVHAPVFTMSVEVDGKTYEASGPSKKTAKLHVAVKVLQDKGLPTG 484  elephant shark

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