Conserved Protein Domain Family
bHLH-PAS_dCLOCK
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cd19735: bHLH-PAS_dCLOCK 
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in Drosophila melanogaster Circadian locomotor output cycles protein kaput (dCLOCK) and similar proteins
dCLOCK, also termed dPAS1, is a bHLH-PAS Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours.
Links
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Statistics
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PSSM-Id: 381578
Aligned: 8 rows
Threshold Bit Score: 154.953
Created: 6-Jul-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Homo sapiens CLOCK (4H10)-BMAL1 basic helix-loop-helix domains binds E-box DNA.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                   #  ##  ## ##   #                 ##                                   
O61735          7 DKDDTKSFLCRKSRNLSEKKRRDQFNSLVNDLSALISTSSRKMDKSTVLKSTIAFLKNHNEATDRSKVFEIQQDWKPAFL 86   fruit fly
PVD35143      571 LEDDEKDNVKRKTRNLSEKKRRDQFNMLINELCSMVAANNKKMDKSTVLKSAIQFLKTHQEISVQSAANEIKEDWKPTFL 650  Pomacea canaliculata
ELU13627       21 YSFISFSFKSRKSRNLSEKKRRDQFNMLINELFSMVATSNRKMDKTTTLKTTIAFLRQHNEVTQQSHIHEVSEDWKPSFL 100  Capitella teleta
EEC10353       27 NKRSDWALARSKSRNLSEKKRRDQFNMLINELCSMVSTSARKMDKSTVLRSTIAFLRSHNDVSSQSQAQEGQENWKPSFL 106  black-legged tick
XP_013385688    4 EEEDAKDNIKRKSRNLSEKKRRDQFNVLVSDLCNMVSKGNRRMDKSSVLKSTIAYLKTHNESITQSQQHEIHDDWKPHFL 83   Lingula anatina
XP_006813633   54 SDENDRETHKRKIRNANEKKRRDQFNVLIDELCVMVSADSKKMDKSAVLKATIAFLKHHNEVVVHTPQGDIDEKWKPPFL 133  Saccoglossus kowal...
XP_011672554   22 DGEDSKDTTKRKSRNASEKKRRDQFNVLIQELCSMVSTKTRKLDKSAVLRATIHFLKAHNDMVMKSEKNAINENWKPSFL 101  purple sea urchin
EFX79971       34 DEVDEKGVIKRKSRNLSEKKRRDQFNILINELCSMVCTGKRKMDKSTILKSAISFIRNHNQVTMQSHCQESVQEDWKPSF 113  common water flea

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