4PIR,6BE1


Conserved Protein Domain Family
LGIC_ECD_5-HT3A
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cd19011: LGIC_ECD_5-HT3A 
extracellular domain of serotonin 5-hydroxytryptamine receptor (5-HT3) receptor subunit A (5HT3A)
This subfamily contains extracellular domain of subunit A of serotonin 5-HT3 receptor (5-HT3AR), encoded by the HTR3A gene. 5-HT3A subunit forms a homopentameric complex or a heterologous combination with other subunits (B-E). Heteromeric combination of A and B subunits provides the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. 5-HT3A receptors are located in the dorsal vagal complex of the brainstem and in the gastrointestinal (GI) tract, and form a channel circuit that controls gut motility, secretion, visceral perception, and the emesis reflex. These receptors are implicated in several GI and psychiatric disorder conditions including anxiety, depression, bipolar disorder, and irritable bowel syndrome (IBS). Several 5-HT3AR antagonists, such as the isoquinoline Palonosetron, are in clinical use to control emetic reflexes associated with gastrointestinal pathologies and cancer therapies. SNPs in the 5-HT3A serotonin receptor gene are associated with psychiatric disorders.
Links
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Statistics
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PSSM-Id: 349812
Aligned: 7 rows
Threshold Bit Score: 391.512
Created: 2-Oct-2017
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
pentamerCys-loop
Conserved site includes 46 residues -Click on image for an interactive view with Cn3D
Feature 1:pentamer interface [polypeptide binding site]
Evidence:
  • Structure:4PIR: Mus musculus 5-hydroxytryptamine receptor 3A (5-HT3A) subunit beta-3 extracellular domain interacts with adjacent domains and forms a pentamer; contacts at 4.0A
    - View structure with Cn3D
  • Structure:6BEI: Mus musculus 5-hydroxytryptamine receptor 3A (5-HT3A) extracellular domain interacts with adjacent subunits and forms a pentamer; contacts at 4.0A
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1     ##  ##                                    #  #     ##    # #        #           
4PIR_A     12 LLRLSDHLLANY.[1].KGVRPV.[1].DWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPE.[1]. 79  house mouse
6BE1_A      7 LLRLSDHLLANY.[1].KGVRPV.[1].DWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPE.[1]. 74  house mouse
P46098     34 LLRLSDYLLTNY.[1].KGVRPV.[1].DWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPE.[1]. 101 human
KPP75179    1 MVRLSDYLTEGY.[1].KGVRPV.[1].NWTRSTTVAIDLMVYAILSVDEKNQVLTTYIWYRQQWTDEFLFWNPE.[1]. 68  Asian bonytongue
KYO42650   39 LLQLSEHLLTHY.[1].KGVRPV.[1].DWRTTTNVAIDVMVYAILNVDEKNQVLTTYIWYRQHWIDEFLKWDPE.[1]. 106 American alligator
OCT70523   33 LLQLSDHLMEGY.[1].KGVRPV.[1].DWRQTTTVYIDVMVYAILGVDEKNQVLTTYIWYRQFWVDEFLTWDPK.[1]. 100 African clawed frog
OCT72561   33 SMQLYKHLFNGY.[1].KGLRPV.[1].NWRNITTVYIDVSVYAILNVDEKNQFMTTYIWYSQYWTDEHLKWNPE.[1]. 100 African clawed frog


Feature 1       #  # # #        ## # # ## ### ###     # ###       # ### #   # ##              
4PIR_A     80 FDNVTKLSIPTD.[1].IWVPDILINEFVDVGKSP.[1].IPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSL 151 house mouse
6BE1_A     75 FDNVTKLSIPTD.[1].IWVPDILINEFVDVGKSP.[1].IPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSL 146 house mouse
P46098    102 FDNITKLSIPTD.[1].IWVPDILINEFVDVGKSP.[1].IPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSL 173 human
KPP75179   69 FDNVKQVSVPTS.[1].VWMPDILINEFVDVGKSP.[1].IPYVYVGFDGVVQNYKPIQVMTACSLNIYNFPFDVQNCSL 140 Asian bonytongue
KYO42650  107 FDNITQVSLPTE.[1].IWVPDILINEFVDVGKSP.[1].IPYVYVLHQGEVQNLKPIQVVTACSLDIYNFPFDVQNCSL 178 American alligator
OCT70523  101 FENVSQISIPTE.[1].IWVPDILINEFVDVGKSP.[1].IPYVYVNHEGRVQNYKPIQVVTACSLNIYNFPFDVQNCSL 172 African clawed frog
OCT72561  101 FDDIQRIAIPTN.[1].VWVPDILIQELVDTGKSP.[1].TPYVYVNYEGTIENSKPIQAVTTCKLRIFYFPFDVQKCNI 172 African clawed frog


Feature 1         ###     #                ##  #                                  
4PIR_A    152 TFTSWLH.[3].DINITLWRSP.[8].IFINQGEWELLEVFPQFKEFS.[4].NSYAEMKFYVIIRRR 219 house mouse
6BE1_A    147 TFTSWLH.[3].DINITLWRSP.[8].IFINQGEWELLEVFPQFKEFS.[4].NSYAEMKFYVIIRRR 214 house mouse
P46098    174 TFTSWLH.[3].DINISLWRLP.[8].VFMNQGEWELLGVLPYFREFS.[4].NYYAEMKFYVVIRRR 241 human
KPP75179  141 TFQSWLH.[3].DINISLLRTP.[8].VFMNQGEWELLHILSKYNTFS.[4].DYYAEIKFNVVIRRR 208 Asian bonytongue
KYO42650  179 TFTSWLH.[3].DINLSLWRHP.[8].VFLNQGEWELLCVLSHFREFS.[4].DSYPEMKFYVVIRRR 246 American alligator
OCT70523  173 TFTSWLH.[3].DINVSLWRTP.[8].VFMNKGEWELLSVLSQYRKFV.[3].DSFAEMKFHVVIKRR 239 African clawed frog
OCT72561  173 TFSSWLF.[3].DLNITLKRSA.[8].VFMNNGEWDLRGVLPKYNSLK.[3].ERYAEEVLTVVIRRR 239 African clawed frog

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