2PL3


Conserved Protein Domain Family
DEADc_DDX10

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cd17941: DEADc_DDX10 
Click on image for an interactive view with Cn3D
DEAD-box helicase domain of DEAD box protein 10
Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350699
Aligned: 16 rows
Threshold Bit Score: 311.917
Created: 30-Jan-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingDEAD box
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                    # # #      #                 ########                               
2PL3_A        36 TLKGLQ.[2].QYRLVT.[1].IQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRL.[5].DGLGVLIISPTRE 108 human
AAZ11538      73 TQLGLE.[2].GYKLLT.[1].IQSDALHLALAGYDVLGAARTGSGKTLCFIVPLLELLYVE.[5].MGIGALVLSPTRE 145 Trypanosoma brucei b...
NP_573230     83 TQKALA.[2].KFVHPT.[1].VQRDSIGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMN.[5].DGVGAIIISPTRE 155 fruit fly
EGD78972      66 TKKGLA.[2].GFIKPT.[1].IQKATLKHALAGRDVLGAAKTGSGKTLAFLIPVLEKLNRE.[5].LGIGAVVVSPTRE 138 Salpingoeca sp. ATCC...
XP_001922220  81 TLKGLL.[2].QYRQPT.[1].IQRQTIGFALQGRDVLGAAKTGSGKTLAFLIPVLECLYRE.[5].DGLGALIISPTRE 153 zebrafish
ADY41663      77 TLKGLE.[2].NFKRPT.[1].IQRDSLQYSLTGVDVVGAAKTGSGKTLALLIPLLECLWRQ.[6].DGLGALVISPTRE 150 pig roundworm
Q5ZJF6        84 TLKGLQ.[2].QYRMVT.[1].IQRQTIGLALQGKDVLGAAKTGSGKTLAFIVPALELLYRL.[5].DGLGVLIISPTRE 156 chicken
Q54Q94       152 TLKALT.[2].KFLKLT.[1].IQRASLPHTLCGRDILGAAKTGSGKTLSFILPILETLWRN.[5].DGIGAIVLSPTRE 224 Dictyostelium discoi...
CBK23092      73 TKKGLN.[2].GFTEMT.[1].IQQKSLISALMGRDILGCAKTGSGKTLAFLIPALECLYRE.[5].DGIGIVIISPTRE 145 Blastocystis hominis
P0CQ83        71 TQKGLK.[2].HFLNPT.[1].IQSLAIPPALQARDILGSAKTGSGKTLAFLIPLLERLYLE.[5].DGLGAVVISPTRE 143 Cryptococcus neoform...

Feature 1                                                                                      # 
2PL3_A       109 LAYQTFEVLRKVG.[2].HDFSAGLIIGG.[1].DLKHEAERINNINILVCTPGRLLQHMDE.[4].HATDLQMLVLDEA 180 human
AAZ11538     146 LALQIFKVLQLVG.[2].HVMSAALLTGG.[1].DVNEERKRVSAISIIVGTPGRVLHHLED.[4].VTDNLQMLVMDEA 217 Trypanosoma brucei b...
NP_573230    156 LAYQIFETLKKVG.[2].HDFSAGLIIGG.[1].NLKFERTRMDQCNILICTPGRLLQHMDE.[4].NTSTMEMLVLDEA 227 fruit fly
EGD78972     139 LAQQTYNTLVQVA.[2].HEMSCALFIGG.[1].NVKIEKTMAATRNIIICTPGRLVQHMDE.[4].GFDNLQVLVLDEA 210 Salpingoeca sp. ATCC...
XP_001922220 154 LAYQTFEVLRKVG.[2].HEFSAGLVIGG.[1].DLKDESEKIHRTNIIICTPGRLLQHMDE.[4].HASDLHMLVLDEA 225 zebrafish
ADY41663     151 LAYQTFHVLNKIG.[2].HNFSAALLIGG.[1].DVEFEKNRLATMNIVVCTPGRLLQHMDE.[4].SCEQLQILIIDEA 222 pig roundworm
Q5ZJF6       157 LAFQTFKVLRKVG.[2].HDFSAGLIIGG.[1].DLKEESERIHHINMLICTPGRLLQHMDE.[4].YASDLQMLILDEA 228 chicken
Q54Q94       225 LAIQIFDVLKAVG.[2].HTFSAGLIIGG.[1].NVQQEKDKINAMNILIATPGRLLQHMDE.[4].DCSNLKILVLDEA 296 Dictyostelium discoi...
CBK23092     146 LAMQIFDVLCTIG.[2].HSFSAGLVIGG.[1].DFEEEQSRIVSMNILVATPGRFLQHLEQ.[4].DCSNVRGLVLDEV 217 Blastocystis hominis
P0CQ83       144 LAVQTFMQLRDIG.[2].HNFSAGLVIGG.[1].PLKEEQERLGRMNILIATPGRLLQHLDS.[4].DSSAVKVLVLDEA 215 Cryptococcus neoform...

Feature 1                                                                      
2PL3_A       181 DRIL.[1].MGFADTMNAVIENLP.[ 1].KRQTLLFSATQTKSVKDLARLSLKNPEYVWVH 233 human
AAZ11538     218 DRLL.[1].MGFREVLSGILKQLP.[ 1].QRQTLMFSATQTTDVQMLGQMSLRNQRYVSAH 270 Trypanosoma brucei brucei strain 927/4...
NP_573230    228 DRCL.[1].MGFQKTLNSIIENFP.[ 1].VRQTLLFSATQTNTVQDLARLNLKDPVYVGYG 280 fruit fly
EGD78972     211 DRLL.[1].SGFKEEVDRIVSEMP.[ 1].HRQTLLFSATQTAEVDELARLSLHNPVFINVH 263 Salpingoeca sp. ATCC50818
XP_001922220 226 DRIL.[1].MGFADTLNAIVENLP.[ 1].SRQTLLFSATQTRSVKDLARLSLKDPEYVWVH 278 zebrafish
ADY41663     223 DRIL.[1].LGFQQQMNAIVENLP.[ 1].TRQTLLFSATQTKNVNDLARLALKDPVYVSVH 275 pig roundworm
Q5ZJF6       229 DRIL.[1].MGFADTMNAIIENLP.[ 1].KRQTLLFSATQTKSVKDLARLSLKDPEYVWVH 281 chicken
Q54Q94       297 DRIL.[1].LGFSKCLNSIVENLP.[ 1].ERQTLLFSATQTKSIRDLARLSLQEPEYISVY 349 Dictyostelium discoideum
CBK23092     218 DRCL.[1].MGFKTTIDHIVDSLG.[ 1].DRQTQLFSATIDENVKTLASSILSNPVSINVN 270 Blastocystis hominis
P0CQ83       216 DRLL.[1].LGFLPALKAIVSHFS.[10].SRQTLLFSATQSKDLAALAKLSLYEPLYISCN 277 Cryptococcus neoformans var. neoforman...

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