3EIQ,1QVA,2J0U,2J0U,2HYI,2J0Q,2HXY,2XB2,1QDE,2G9N,1FUU,3BOR,2ZU6,2VSO


Conserved Protein Domain Family
DEADc_EIF4A

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cd17939: DEADc_EIF4A 
Click on image for an interactive view with Cn3D
DEAD-box helicase domain of eukaryotic initiation factor 4A
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Statistics
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PSSM-Id: 350697
Aligned: 22 rows
Threshold Bit Score: 316.573
Created: 30-Jan-2014
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
 
ATP bindingDEAD box
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                       ## ###  #                 ########                               
3EIQ_A        44 DMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQI.[7].QALVLAPTRELAQQIQ 125 human
Q0E2Q3        52 AQFISESLIGETQTKDLDKPSAVHQRGIVPLCNGLDIIQQSLFGTTVTLCCGILQRLDY.[5].QALVLVPTHDLAHETQ 131 Japanese rice
Q8SQM5        42 DYGLKEDLLKGIYSIGFETPSFIQKAAIQPIIDGRDIRAQAQSGTGKTGAFAVAALQIC.[7].QILVLASTREIAAQNA 123 Encephalitozoon cuni...
AAF24007      16 EMELKRELLKGIYGYGFERPSFIQQRGILPIINKEDVVAQSQSGTGKTATFVIGTLQNL.[7].KNLVLVPTRELATQVE 97  Guillardia theta
Q38F76        30 DMPLHQNLLRGIYSHGFEKPSSIQQRAIVPFTRGGDIIAQAQSGTGKTGAFSIGLLQRL.[7].QGLVLSPTRELAMQTA 111 Trypanosoma brucei b...
EGD78700     103 DMNLSMELLRGVYAYGYEAPTAIQQRAIVPISSGRDIIVQAPSGMGKTATFSIGSLQRV.[7].QLLVLSPTRELAIQTA 184 Salpingoeca sp. ATCC...
XP_003239737  21 EMGLNDKLVQGIYGYGYEKPSLIQQRGILPLLKKRDVIAQAQSGTGKTATFVIGTLQNI.[7].CVLTITPTRELAFQIE 102 Cryptomonas paramecium
CAK77099      60 DLTLSKDLLRGIFSYGFERPSAIQQKAIKPIILGKDVLAQAQSGTGKTGTFTIGALQRI.[7].QVIILAPVRELAKQIY 141 Paramecium tetraurelia
2J0Q_A        41 TMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCL.[7].QALILAPTRELAVQIQ 122 human
2HXY_A        20 TMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCL.[7].QALILAPTRELAVQIQ 101 human

Feature 1                                                                                       
3EIQ_A       126 KVVMALG.[4].ASCHACIGG.[3].RAEVQKLQ.[2].APHIIVGTPGRVFDMLNR.[3].SPKYIKMFVLDEADEML 196 human
Q0E2Q3       132 NVIGVLG.[4].AKAHAFCGG.[3].HEDQQILS.[1].GVQVAVGTPCHVLGMLQG.[3].CPDHIRMFVLDEADEVL 201 Japanese rice
Q8SQM5       124 ARFEDLG.[4].ARVALLSGG.[3].AADKVALE.[1].KPHIVVGTPGRVEHMINI.[3].SMDNIKLFVIDEADEML 193 Encephalitozoon cunic...
AAF24007      98 QVFKSIG.[4].IKTQLLTGG.[3].QITNKEQY.[1].KPQIVIGTPGKVLDSLSK.[3].YIENLEYLVVDEADEMF 167 Guillardia theta
Q38F76       112 EVITRIG.[8].SFCATFVGG.[3].QDDYRKLQ.[1].GTIVAVGTPGRVVDVTKR.[3].RTESLRVLVLDEADEML 185 Trypanosoma brucei br...
EGD78700     185 DACQSLG.[4].VRVLPLIGG.[3].RDQRTALR.[2].GIHVVCGTPGRVKHMLSD.[3].DCRQLTTIVLDEADELL 255 Salpingoeca sp. ATCC5...
XP_003239737 103 QSFKEIG.[4].VKTQVCVGG.[4].RDIRYLLK.[1].NPRIIIATPGRLFDILSL.[3].ILKKLQYVIIDEADEMF 173 Cryptomonas paramecium
CAK77099     142 DVVKGIG.[4].IEAFCCIGG.[3].QETREKCK.[1].GVHIIIATPGRLIDMMKN.[3].DATFMRLLVVDEADQML 211 Paramecium tetraurelia
2J0Q_A       123 KGLLALG.[4].VQCHACIGG.[3].GEDIRKLD.[1].GQHVVAGTPGRVFDMIRR.[3].RTRAIKMLVLDEADEML 192 human
2HXY_A       102 KGLLALG.[4].VQCHACIGG.[3].GEDIRKLD.[1].GQHVVAGTPGRVFDMIRR.[3].RTRAIKMLVLDEADEML 171 human

Feature 1                                                              
3EIQ_A       197 .[1].RGFKDQIYDIFQKLN.[2].TQVVLLSATMPSDVLEVTKKFMRDPIRIL 243 human
Q0E2Q3       202      RGFKDQIHGIIQFLP.[2].TQFGFFSASMSHEALEMCRKYMNKPVEII 247 Japanese rice
Q8SQM5       194 .[1].AGFQEQVKSIFRRIT.[4].VQIAMFSATYDEEELRVSEEILINPVIID 242 Encephalitozoon cuniculi GB-M1
AAF24007     168 .[1].RGFKIQVLKIIKYLP.[2].AKIALFSATMPIETLEIVELFMTNPVKIL 214 Guillardia theta
Q38F76       186 .[1].QGFAEQIYDIFRFLP.[2].IQVALFSATMPDDVLELTKKFMRDPTRIL 232 Trypanosoma brucei brucei
EGD78700     256      EYFQDDIYDVFQFVP.[2].AQVVLVTATTTDVLLKISKKVLRNPVNIL 301 Salpingoeca sp. ATCC50818
XP_003239737 174 .[1].KGFKFQIYRIFKFVP.[2].CTIGLFSATLPKEIIQIVETIMNEPVRIF 220 Cryptomonas paramecium
CAK77099     212 .[1].QGFSDNFAEILKMVP.[2].IQIALFSATFPQEIIELSKQFLRDGTAKI 258 Paramecium tetraurelia
2J0Q_A       193 .[1].KGFKEQIYDVYRYLP.[2].TQVVLISATLPHEILEMTNKFMTDPIRIL 239 human
2HXY_A       172 .[1].KGFKEQIYDVYRYLP.[2].TQVVLISATLPHEILEMTNKFMTDPIRIL 218 human

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