5ECG,1GZH,1KZY


Conserved Protein Domain Family
BRCT_p53bp1_rpt2

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cd17724: BRCT_p53bp1_rpt2 
Second (C-terminal) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins
p53BP1, also termed 53BP1, or TP53-binding protein 1 (TP53BP1) , is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics, and class-switch recombination (CSR) during antibody genesis. TP53BP1 contains two tandem BRCT repeats. This family corresponds to the second BRCT domain.
Statistics
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PSSM-Id: 349356
Aligned: 54 rows
Threshold Bit Score: 38.8924
Created: 14-Apr-2008
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
peptide bindingBRCT sequence
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide binding site [polypeptide binding site]
Evidence:
  • Structure:5ECG: Homo sapiens 53bp1 binds H2AX-pSer139 (gammaH2AX) peptide, contacts at 4A.
    View structure with Cn3D
  • Comment: the interaction of 53BP1 with gammaH2AX is required for sustaining the 53BP1-dependent focal concentration of activated ATM that facilitates repair of DNA double-strand breaks in heterochromatin in G1

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                          #                                                 #      
5ECG_C     158 PFQNLKVLLVSDQ.[ 5].ELWSEIL.[ 2].GGAASVKQHH.[13].DVVVTDP.[14].LPVVSQEWVIQCLIVG 244  human
KIK08283  1140 LFAEKSILCVGPE.[21].NAMARVI.[ 2].MGAESVEAVT.[13].FVIIREA.[ 9].ATTVHWNWVKDCLIAS 1237 Laccaria amethystina LaA...
CDZ96756  1236 PFTNLTMLYLNPK.[ 4].ELVVFLC.[ 2].LGAKSITTTS.[14].DILVVKD.[17].LEIVNEEWVKQCSIVG 1325 Xanthophyllomyces dendro...
CEL52494  1068 PFKGSSVLCIFKR.[12].KFYSRVA.[ 2].MGASTVHLVP.[16].DYVICEN.[12].AAGRSTEWVKQCIIMG 1162 Rhizoctonia solani AG-1 IB
EJU05264  1246 PLQGKRLFFLVSK.[ 2].NFLKGRL.[ 6].MGAEHVEKTS.[11].DYLYWPD.[12].AKRVGPNWIKQCLITG 1329 Dacryopinax primogenitus
KKY16249  1175 PFAGESVIFVAGK.[ 7].KPFIFLL.[ 2].MGARCITRVH.[16].YVVVDDK.[25].PRVIGTDFIAQSIILG 1277 Phaeomoniella chlamydospora
KIJ41195   305 PFKDKSFLCIGGS.[ 1].SFFSDVR.[27].MGASHVQVVT.[13].DYTVVDE.[ 9].SRAVDISWIKKCVIAG 407  Sphaerobolus stellatus SS14
KZT40125   879 AFIGEKVLCLGPS.[16].EASSSVP.[ 5].MGALHVEATV.[13].HIILPDG.[ 7].TKYIYLSAVKDCLISC 972  Sistotremastrum suecicum...
CDK26809   731 ILAHYQVLIINKS.[ 5].ETLLFIL.[ 2].LGVKTIHFVA.[18].TAVYSED.[54].IRYINWEWIVQCVICS 862  Kuraishia capsulata CBS ...
ODV85991  1294 IFKNCQFLIHDDF.[ 9].DEVEFFI.[ 2].LGCKDIRLID.[13].DIIYLYS.[43].VRVVNWEWLVQCIIAN 1413 Candida arabinofermentan...

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