Conserved Protein Domain Family
MFS_SLC22A6_OAT1_like

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cd17446: MFS_SLC22A6_OAT1_like 
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily
This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 341004
Aligned: 7 rows
Threshold Bit Score: 538.926
Created: 30-Jan-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                         ##  ##  #                        #                             
Q8TCC7        88 TQRAMEPCLDGWVYNSTKDSIVTEWDLVCN.[4].KEMAQSIFMAGILIGGLVLGDLSD.[3].RRPILTCSYLLLAASG 164 human
Q66J54       105 LATRPCTEGWEYSKDEFNSTIITEWDLVCG.[4].RQLAQSVYMGGVLVGAIILGGLSD.[3].RRALLIWSYFQMAVSG 181 African clawed frog
Q66J52       102 LETEPCLDGWVYDHSEFASTIITQWDLVCN.[4].RQVAQSIYMAGVLVGSILFGGLSD.[3].RRPLNIWSNLQMFVTG 178 African clawed frog
Q4U2R8       100 GATEPCTDGWIYDNSTFPSTIVTEWDLVCS.[4].RQLAQSLYMVGVLLGAMVFGYLAD.[3].RRKVLILNYLQTAVSG 176 human
Q6NYN7       108 TETQSCEDGWFYNMTEMSSTIITEWDLVCD.[4].KQMSQTTYMGGVLVGAIVFGGLSD.[3].RRVLLLISNLMMAIGG 184 zebrafish
A6NK97       102 AATEGCKDGWVYNRSVFPSTIVMEWDLVCE.[4].RDLAQSVYMAGVLVGAAVFGSLAD.[3].CKGPLVWSYLQLAASG 178 human
XP_007070391 111 LETEPCADGWVYDKSIFTSTIITEWDLVCD.[4].KQMAQSIYMAGILAGGIIFGGLSD.[3].RRSLLIWCYLQMAVTG 187 green sea turtle

Feature 1                          ## ###  #        #  ##  #                                     
Q8TCC7       165 SG.[10].MVFRFLCGFGISGITLSTVIL.[13].STALGYCYTFGQFILPGL.[6].WRWLQLTVSIPFFVFFLSSWWT 256 human
Q66J54       182 LC.[10].CIFRFLTGMALSGIGLNTTAL.[13].GTLAGFSYTVGQLLLAGL.[6].WRWLQLCVSLPFFIFFLYSWWF 273 African clawed frog
Q66J52       179 IC.[10].CIFRFLTGVAFSGIVLNSYSL.[13].STATGYCYTMGQLVLVGL.[6].WQWLQLAASIPFFFYFLYSWWI 270 African clawed frog
Q4U2R8       177 TC.[10].CAFRLLSGMALAGISLNCMTL.[13].GTLIGYVYSLGQFLLAGV.[6].WRHLQLLVSAPFFAFFIYSWFF 268 human
Q6NYN7       185 TC.[10].CVFRVCCGMALSGLVLNSFSL.[13].GTGTGYCYTTGQLILAAV.[6].WRWLTLAVSLPFYVSFLYSWWF 276 zebrafish
A6NK97       179 AA.[10].CVFRFLMGMTFSGIILNSVSL.[13].GILLGYSFTLGQLILAGV.[6].WRCLQFAISAPFLIFFLYSWWL 270 human
XP_007070391 188 TC.[10].CIFRFLTGMAFSGIVLNGVSL.[13].GTMYGYCYTIGQFILAGV.[6].WRWLQLVVSLPYFICFIYSWWF 279 green sea turtle

Feature 1                        #  ##  ###  #               #   #                               
Q8TCC7       257 P.[67].RMTFCLSLAWFATGFAYYSLAMGV.[9].LQIIFGGVDVPAKFITILSLSYL.[6].AAALLLAGGAILALTF 402 human
Q66J54       274 P.[67].RISCALSLVWFSTSFAYYGLAMDL.[9].IQVIFGAVDFPAKIFSTTAMIYV.[6].LMSLILGGVVILANSF 419 African clawed frog
Q66J52       271 P.[68].RISFCISCTWFSTSFAYYGLALDL.[9].IQIIFGTVDIPAKFISYFITTYV.[6].AITLILAGIAILVNIS 417 African clawed frog
Q4U2R8       269 I.[67].HLFLCLSMLWFATSFAYYGLVMDL.[9].IQVIFGAVDLPAKLVGFLVINSL.[6].MAALLLAGICILLNGV 414 human
Q6NYN7       277 L.[67].TITICLSAVWFSTSFAYYGLSMDL.[9].IQIIFGAVDIPAKIIVTICMSML.[6].CGALVLAGIMILINLL 422 zebrafish
A6NK97       271 P.[67].KVTCCLMVIWFSNSVAYYGLAMDL.[9].VQALFGIINTPAMLVATATMIYV.[6].ASFLILAGLMVIANMF 416 human
XP_007070391 280 A.[67].RISFCLCFVWFSTSFAYYGLAMDL.[9].IQMVFGAVDFPAKFISVLTISFI.[6].ALTLILAGLSILANIF 425 green sea turtle

Feature 1                     ##   #   #                   #  ##  ##  #                          
Q8TCC7       403 V.[11].AVFGKGCLSSSFSCLFLYTSELYPTVIR.[1].TGMGVSNLWTRVGSMVSPL.[11].PNIIYGITALLGGSA 488 human
Q66J54       420 V.[11].AVFGKGCLAASFSCVFLYTTELYPTVIR.[1].SGLGLCSTMARIGGIVAPL.[11].PLVIYGGAPIISGLC 505 African clawed frog
Q66J52       418 V.[11].AVFGKGCLAASFNCLYLYTGELYPTVIR.[1].TGMGLGAMMARLGGIIAPL.[11].PLIIFGCLPILSGIA 503 African clawed frog
Q4U2R8       415 I.[11].AVLGKGCLAASFNCIFLYTGELYPTMIR.[1].TGMGMGSTMARVGSIVSPL.[11].PLFIYGAVPVAASAV 500 human
Q6NYN7       423 V.[11].AVIGKGCLAASFNCCYLYAGELYPTVIR.[1].SGMGWVSMMARFGAMVAPM.[11].PGFIYGGAPIVSGIF 508 zebrafish
A6NK97       417 V.[11].AALGKGCLASSFICVYLFTGELYPTEIR.[1].MGMGFASVHARLGGLTAPL.[11].PPVSFGATAILAGLA 502 human
XP_007070391 426 V.[11].AVFGKGCLAASFNCVYLYTSELYPTVIR.[1].TGMGLSNTMARLGSITAPL.[11].PLIIYGAAPIISGIA 511 green sea turtle

Feature 1             
Q8TCC7       489 ALFLP 493 human
Q66J54       506 VFFLP 510 African clawed frog
Q66J52       504 GCFLP 508 African clawed frog
Q4U2R8       501 TVLLP 505 human
Q6NYN7       509 AFFLP 513 zebrafish
A6NK97       503 VCVLT 507 human
XP_007070391 512 ATFLP 516 green sea turtle

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