Conserved Protein Domain Family
MFS_MFSD10

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cd17389: MFS_MFSD10, with user query added  
Major facilitator superfamily domain-containing protein 10
Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
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PSSM-Id: 340947
Aligned: 17 rows
Threshold Bit Score: 491.404
Created: 14-Mar-2016
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                       #                                                
query         52 ERH.[28].RYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLG.[1].RPVMMLSLTGLAISYAVW.[5].FKAFLASRV 149
Q14728        51 ESH.[28].RYNSVLFGGLIGSAFSVLQFLCAPLTGATSDCLG.[1].RPVMLLCLMGVATSYAVW.[5].FAAFLASRL 148 human
NP_524429     76 EHY.[27].RYISVLFGGFLGSMFSFLQFVASPIVGGLSDYYG.[1].KPVLLACASGIALSYLIW.[5].FALFVLARF 172 fruit fly
XP_420825     51 DYY.[28].KYNSVLFGGLIGSMFSILQFFSSPLTGAVSDCLG.[1].RPVILMTAMGLIASYALW.[5].FGVFLLSRM 148 chicken
NP_001088384  46 QHF.[28].KYNSVLFGGFIGTIFSLLQFICSPLTGAASDYLG.[1].RQAMMITAVGLIFSYTLW.[5].FGIFILSRV 143 African clawed frog
XP_005998243  55 DHY.[28].KYNSVLFGGLIGSIFSLLQFVSSPLTGAASDYFG.[1].RQLMIMTMVGLIVSYGLW.[5].FGVFLLSRV 152 coelacanth
XP_007903449  56 DYY.[29].KYNSVLFGGLIGTIFSLLQFLLSPVTGAASDYFG.[1].RLLMMLTTAGLIASYALW.[5].FGLFLLSRV 154 elephant shark
XP_013396076  52 DYY.[29].RWNSVLFGGLIGSLFSLLQFLASPMIGAASDYYG.[1].KPLMLLNLIGIAVSYAIW.[5].FTIFVLARI 150 Lingula anatina
ELU06772      28 DYY.[29].RWNSVLFGGLIGSMFSFLQFLASPLMGAMSDVYG.[1].RPVVLLSTIGVGISYVIW.[5].FSLFVLSRI 126 Capitella teleta

Feature 1             ## ###  #                #  ##  #                                          
query        150 IGGISKGNVNLSTAIVADL.[7].QGMAVIGVAFSLAFTLGPMLGAFL.[ 2].EMVPWISLLFAISDMLFIFCFLPETL 227
Q14728       149 IGGISKGNVSLSTAIVADL.[7].QGMAVIGVAFSLGFTLGPMLGASL.[ 2].EMAPWFALLFAASDLLFIFCFLPETL 226 human
NP_524429    173 VGGISKGNISLCMSVITDV.[7].RGMALVGVAFSLGFIVGPMIGALF.[12].VLPSLLAFGLAVGDLVVLACCLRETL 260 fruit fly
XP_420825    149 VGGISKGNVSLCTAIIADL.[7].KGMAMIGVAFSLGFTLGPMIGAYL.[11].LRSALLALTFAAADLIFIFFLLPETL 235 chicken
NP_001088384 144 VGGLSKGNVSLCTAIIADL.[7].TGMAMIGVAFSLGFTIGPMIGAYF.[11].VRPALLALFFAVADLIFIFLFLPETL 230 African clawed frog
XP_005998243 153 VGGISKANVSLSTAIIADL.[7].KGMAMIGVAFSLGFTVGPMIGAYF.[10].LCPAILALMFALADLMFISLFLPETL 238 coelacanth
XP_007903449 155 VGGMSKGNVSLSTAIIADL.[7].KGMAMIGVAFSLGFTIGPMMGAYF.[11].LQPAQLALMFAVSDLLFIFFFLPETL 241 elephant shark
XP_013396076 151 VGGISKGNISLSTAIVTDI.[7].KGMALIGIAFSVGFLIGPLIGAYF.[12].VAPALFALTLAVINVVFVYACFKETL 238 Lingula anatina
ELU06772     127 IGGISKGNVSISTAIVADI.[7].RGMAVIGIAFSVGFIIGPMIGAGF.[11].SAPALFAIFLLSVDLLYIYCFLKETL 213 Capitella teleta

Feature 1                                   #  ##  ###  #                       #   #        
query        228 P      QEKR.[4].TLGF.[38].VYFLYLFLFSGLEYTLSFL.[9].LQQGKMFFFIGLTMATIQGTYARRIS 332
Q14728       227 P.[42].SSLR     RLGL      VYFLYLFLFSGLEYTLSFL.[9].LQQGKMFFLIGLTMATIQGAYARRIH 331 human
NP_524429    261 P.[38].AALR     SIGL      VYFLYLFLYSGLEFTVTFL.[9].MDQAKMFLTTGVIMTLLQGSVVRRLP 361 fruit fly
XP_420825    236 P.[42].QNLK     ILGL      AYFLYLFLFSGLEYTLSFL.[9].MQQGKMFFFIGITMAVIQGGYARRIK 340 chicken
NP_001088384 231 P.[42].QKLR     LLGM      VYFLYLFLFSGLEYTLSFL.[9].MQQGKMFFFIGITMALIQGGYARRIR 335 African clawed frog
XP_005998243 239 P.[42].QNLK     ILGL      VYFLYLFLFSGLEYTLSFL.[9].MQQGKMFFFIGIAMAVIQGGYARRIH 343 coelacanth
XP_007903449 242 P.[43].KNLK     VLGL      VYFLYLFLFSGLEYTLGFL.[9].MQQGKMFFFVGITMAMIQGGYARRIK 347 elephant shark
XP_013396076 239 P.[38].DQMQ     RIGL      VYFLYLFLYSGLEFTLTFL.[9].MKQGKMFFFIGIIMSIVQGGYVRRIK 339 Lingula anatina
ELU06772     214 P.[38].RRMQ     RVGG      VYFLYLFFYSGLEFTLTFL.[9].MKQGKMFFFIGIIMVIIQGGFVRRLK 314 Capitella teleta

Feature 1                                                 ##   #   #                  #  ##  ##  
query        333 .[2].KEAAAVTRAMLLLVPAFLLIG.[7].LGLGLMLYSFAAAVVVPGLSTMVSSYGSP.[2].KGTIMGILRSLGALG 408
Q14728       332 .[2].GEVAAVKRALLLLVPAFLLIG.[7].LGLGLLLYSFAAAVVVPCLSSVVAGYGSP.[2].KGTVMGTLRSLGALA 407 human
NP_524429    362 .[2].KIKGYAIFSLYLIVPAFVVVG.[7].LYAGMTLFAISTAFAVTCLTTLVSKYGND.[2].KGSVLGIFRSLGALA 437 fruit fly
XP_420825    341 .[2].NEIRVVKRAVLLLIPAFLLIG.[7].LSAGLLLYSFAAAIVIPCLSAVVSGYGSA.[2].KGRVMGILRSLGALA 416 chicken
NP_001088384 336 .[2].NEIKAVKRAIILLIPAFLLIG.[7].LGAGLLLYSFAAAIVVPCLSSVVSAYGSA.[2].KGTVMGILRSLGALA 411 African clawed frog
XP_005998243 344 .[2].SEIRAVKMALILLIPAFILIG.[7].LYFGLLLYSFAAAIVVPCLSTMVSAYGSA.[2].KGTVMGILRSLGALA 419 coelacanth
XP_007903449 348 .[2].DEIKVVKRAFFLLIPAFILIG.[7].LYIGLFLYSFAAAVVVPCLSTLVSAFGGA.[2].KGTTMGILRSLGALA 423 elephant shark
XP_013396076 340 .[2].KEKKVALMGIGLVIPSFLVIG.[7].MYCGLALFSFASATVVPCLTTLMSSYGQD.[2].KGTVMGIFRSLGALA 415 Lingula anatina
ELU06772     315 .[2].REISFSMKAMLTLIPAFLLVA.[7].LYAGLSLFAFASAVVVPCLTTHISSYGTV.[2].KGAVLGIFRSLGALA 390 Capitella teleta

Feature 1        #                            
query        409 RALGPVVAASVY.[2].TGAQVCFTVCSA 434
Q14728       408 RAAGPLVAASVY.[2].AGAQACFTTWSG 433 human
NP_524429    438 RALGPVVGCIAF.[2].VGSRITYIAGGL 463 fruit fly
XP_420825    417 RALGPVLSATVY.[2].AGAESCFTICGA 442 chicken
NP_001088384 412 RALGPILSASLY.[2].AGEQICFTVFAF 437 African clawed frog
XP_005998243 420 RAVGPIVSATVY.[2].AGAEVCFVACST 445 coelacanth
XP_007903449 424 RALGPIVAATVY.[2].AGAEVCFTATSA 449 elephant shark
XP_013396076 416 RALGPMAASIVY.[2].LGSTACYSIGGV 441 Lingula anatina
ELU06772     391 RALGPAAACTLY.[2].VGAEACYSIGAV 416 Capitella teleta

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