Conserved Protein Domain Family
VHS_Lsb5

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cd16980: VHS_Lsb5 
VHS (Vps27/Hrs/STAM) domain of LAS seventeen-binding protein 5
LAS seventeen-binding protein 5 (LAS17-binding protein 5, Lsb5, or Lsb5p) localizes to the plasma membrane and plays a role in endocytosis in yeast. It interacts with actin regulators Sla1p and Las17p, ubiquitin, and Arf3p, coupling actin dynamics to membrane trafficking processes. Lsb5p contains an N-terminal VHS domain and a GAT (GGA and TOM) domain. The VHS domain has a superhelical structure similar to the structure of ARM (Armadillo) repeats. It is a right-handed superhelix of eight alpha helices. The VHS domain has been found in a number of proteins, some of which have been implicated in intracellular trafficking and sorting.
Statistics
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PSSM-Id: 340777
Aligned: 68 rows
Threshold Bit Score: 98.4438
Created: 26-May-2015
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative
Feature 1:putative intraprotein/interprotein binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                      ##  #   #                                          ##           
P25369      12 ITETIFRIVS.[2].DYTLEVELAPLIQ.[13].NQEEAARALRKKIK.[4].LQQSRTLDLLDLFISQG.[1].KFTVM 90   Saccharomyces cerevis...
EXX51009    42 VTDYLEQCVN.[4].DWNLIINTCDAVN.[ 4].GAKEATKFIRKKIS.[3].NVQLRTLTVLKAMTENC.[2].KFHAE 113  Rhizophagus irregular...
EPB84451    13 ITTNIEKATN.[6].DWALVFQICDSVN.[ 4].GAKEARKLLQKKMI.[4].KTQVLALEILNSLSENC.[2].KFQPQ 87   Mucor circinelloides ...
CEL60333   265 ISRLIGYTTS.[4].DWSVVMEICDKVN.[ 4].EAKEASKALRKDIQ.[4].AVQLSAARLWAILMRNC.[2].YFVAH 337  Rhizoctonia solani AG...
EIW68575   559 VTVAIQILCS.[4].SLANIYDIIERIN.[ 7].VAKETSRAIRKQFK.[4].SERRAAAKIWLIMMRNV.[3].GFKTH 635  Tremella mesenterica ...
CEG81956    12 ITSKIEQTVN.[4].DWTSVFEICKLVS.[ 4].GAKEARKLLQKKMM.[4].RIQMTSLEIMNALIEND.[2].TMQAE 84   Rhizopus microsporus
CDS14196    14 ITTNVEKATD.[6].DWSLVFAICDVVN.[ 4].GAKEARKLLQKKML.[4].QTQVLALELLDALSQNC.[2].KFQGQ 88   Absidia idahoensis va...
KFH67406    10 ITSQIDTITS.[5].QWDAVAALCETVN.[ 4].GAKEAGKALRKKLR.[4].QQQMNALTLIQAMVDGC.[2].KFKAQ 83   Mortierella verticill...
KFH72464    11 ITAQIEVITN.[5].HWDTLAVLCHMVN.[ 4].GPKEASRALRRRFK.[4].HQRMNSITVTQVLIDGC.[2].KFKAQ 84   Mortierella verticill...
EIE89053    13 ITTKIDQAVD.[6].DWNRVFEICQLVN.[ 4].GAKEARKQLQKKLM.[4].RIQVMCLEVLNALIEND.[2].TMQHQ 87   Rhizopus delemar RA 9...

Feature 1                                                                        
P25369      91 YN     DDKLLQ     RLRGM.[13].EPRIIKKCAAYAISWLNYI.[11].SGLYQLGQTVKQ 158  Saccharomyces cerevisiae S288c
EXX51009   114 IA.[1].KKFLDE.[2].IVAIS.[ 3].DDDIKQKIVTLLGTLTEMF.[ 6].YQISNLYSKLTG 169  Rhizophagus irregularis DAOM 197198w
EPB84451    88 LA.[1].KSFGEE     LHTLA.[ 5].DDRVHGKLAQCLQTWVSQT      GGDPQFGAVRRA 137  Mucor circinelloides f. circinelloi...
CEL60333   338 TT.[1].RKFLGK     IEEVA.[ 5].SPVVRDRLVEVIGTSVYLL.[ 6].KPYQTTWKKLRL 393  Rhizoctonia solani AG-1 IB
EIW68575   636 AT.[1].KKFLQS     LEPII.[ 9].SASTHRMITDILANLVYQY.[ 6].EGLGELWGKVKM 695  Tremella mesenterica DSM 1558
CEG81956    85 VT.[1].KSFGED     LCRLA.[ 5].DPTVMVKLAESLDGWIVRY      QGVSKTEALVKA 134  Rhizopus microsporus
CDS14196    89 LS.[1].KSFAED     LDTLA.[ 5].NDQVHSKLIMCLQNWVTRY.[ 6].IGVHRVYERLTL 144  Absidia idahoensis var. thermophila
KFH67406    84 LA.[1].AKFAED     IEAVV.[ 5].DANVKIRLMERLADWADKF.[ 6].AIIPQLYYSLVR 139  Mortierella verticillata NRRL 6337
KFH72464    85 VA     TKKFAD     LLSYL.[ 6].HPAVRSRLMERLGAWAQSF.[ 6].VVIPQLYQHLSS 140  Mortierella verticillata NRRL 6337
EIE89053    88 IT.[1].KSLGED     LSTLA.[ 8].DPSVMSKLAEYLDTWTSRY.[14].EIVQRISQQRPP 154  Rhizopus delemar RA 99-880

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