Conserved Protein Domain Family
dRING_RMD5A
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cd16794: dRING_RMD5A 
Degenerated RING finger found in protein RMD5 homolog A (RMD5A)
RMD5A is one of the vertebrate homologs of yeast Rmd5p. The biological function of RMD5A remains unclear. RMD5A contains a Lissencephaly type-1-like homology motif (LisH), a C-terminal to LisH motif (CTLH) domain, and a degenerated RING finger that is characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues compared with the classic C3H2C3-/C3HC4-type RING fingers.
Links
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Statistics
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PSSM-Id: 438448
Aligned: 6 rows
Threshold Bit Score: 136.706
Created: 13-Apr-2015
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 4 residue positions
Conserved feature residue pattern:C H C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:The degenerated RING finger is characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues compared with the classic C3H2C3-/C3HC4-type RING fingers, similar to SP-RING fingers.
  • Comment:based on the structures of human Sumo ligases Pias2 and Pias3 with bound Zn2+ ion through their SP-RING fingers
  • Comment:The SP-RING finger is a variant of RING finger; it binds a single Zn ion and lacks the second, fifth, and sixth zinc-binding residues of the consensus C3H2C3-/C3HC4-type RING fingers.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                              # #                     #  #              
Q9H871       332 SIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNG.[1].KLKCPYCPMEQSPGDAKQIFF 391 human
XP_006008673 332 SIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNG.[1].KLKCPYCPMEQSPGDAKQIFF 391 coelacanth
NP_001292351 332 SIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNG.[1].KLKCPYCPMEQSPGDAKQIFF 391 chicken
Q6GLP4       332 SIFACPILRQQTTENNPPMKLVCGHIISRDALNKMFNG.[1].KLKCPYCPMEQSPGDAKQIFF 391 African clawed frog
KPP70400     330 SVFACPILRQQTTESNPPMKLVCGHIISKDALNKMING.[1].KLKCPYCPMEQVPADAKQIYF 389 Asian bonytongue
XP_007896193 365 SIFACPILRQQTTESNPPMKLVCGHIISRDALNKMING.[1].KLKCPYCPMEQAPGDAKQIFF 424 elephant shark

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