Conserved Protein Domain Family
RING-HC_BAR
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cd16497: RING-HC_BAR 
RING finger, HC subclass, found in bifunctional apoptosis regulator (BAR)
BAR, also known as RING finger protein 47, was originally identified as an inhibitor of Bax-induced apoptosis. It participates in the block of apoptosis induced by TNF-family death receptors (extrinsic pathway) and mitochondria-dependent apoptosis (intrinsic pathway). BAR is predominantly expressed by neurons in the central nervous system and is involved in the regulation of neuronal survival. It is an endoplasmic reticulum (ER)-associated RING-type E3 ubiquitin ligase that interacts with BI-1 protein and post-translationally regulates its stability, as well as functioning in ER stress. BAR contains an N-terminal C3HC4-type RING-HC finger, a SAM domain, a coiled-coil domain, and a C-terminal transmembrane (TM) domain. This model corresponds to the RING-HC finger responsible for the binding of ubiquitin conjugating enzymes (E2s).
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Statistics
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PSSM-Id: 438160
Aligned: 11 rows
Threshold Bit Score: 85.253
Created: 2-May-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1            #  #           # #  #  #             #  #         
Q9NZS9         31 EFSCHCCYDILVNPTTLNCGHSFCRHCLALWW.[4].KTECPECREKWEGFPK 82   human
NP_001088347   28 EFSCHCCYDILVNPTTLNCGHSFCRHCLALWW.[4].KTECPECRNTWEGFPK 79   African clawed frog
EOA94950       32 EFHCHCCYDILVNPTTLNCGHSFCRHCLALWW.[4].KNECPECREKWEGFPK 83   mallard
CAF98116       35 EFFCHCCYDVLVNPTTLTCGHSFCRHCLALWW.[4].KNECPECREKWEGFPK 86   spotted green pufferfish
XP_007904630   36 EFSCHCCYDILVNPTTLNCGHSFCRHCLALWW.[4].KTECPECREKWEGFPK 87   elephant shark
XP_006009664   38 EFSCHCCYDILVNPTTLNCGHSFCRHCLALWW.[4].KLECPECREKWQGFPK 89   coelacanth
XP_006818591   56 IFNCGCCYELMVQPTTLNCGHSFCRLCLARWW.[4].NTTCPGCRQQWNGFPH 107  Saccoglossus kowalevskii
XP_013389489   21 DFNCPVCFEMLIDPTTLNCGHNLCRHCLAQWY.[4].RQSCPVCQQAWVGHPK 72   Lingula anatina
ESO93335       23 DFLCSCCFNLMTQPTSLMCGHNFCRGCLARWF.[4].KRECPTCRQKWQGHPK 74   owl limpet
KXJ22759     1189 DFHCGCCYELMVDPTTLNCGHSFCRFCLAQWW.[4].KTTCPECRQSWLGFPK 1240 Exaiptasia pallida
XP_035585945   81 SFLCSICRGLLVRTRLLSCGHQFCRECLYYWF.[2].RNTCPLCRKYVNRNIS 130

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