CDD Conserved Protein Domain Family: 7tmB1_Secretin

cd15930: 7tmB1_Secretin_R-like

secretin receptor-like group of hormone receptors, member of the class B family of seven-transmembrane G protein-coupled receptors

This group represents G protein-coupled receptors for structurally similar peptide hormones that include secretin, growth-hormone-releasing hormone (GHRH), pituitary adenylate cyclase activating polypeptide (PACAP), and vasoactive intestinal peptide (VIP). These receptors are classified into the subfamily B1 of class B GRCRs that consists of the classical hormone receptors and have been identified in all the vertebrates, from fishes to mammals, but are not present in plants, fungi, or prokaryotes. For all class B receptors, the large N-terminal extracellular domain plays a critical role in peptide hormone recognition. Secretin, a polypeptide secreted by entero-endocrine S cells in the small intestine, is involved in maintaining body fluid balance. This polypeptide regulates the secretion of bile and bicarbonate into the duodenum from the pancreatic and biliary ducts, as well as regulates the duodenal pH by the control of gastric acid secretion. Studies with secretin receptor-null mice indicate that secretin plays a role in regulating renal water reabsorption. Secretin mediates its biological actions by elevating intracellular cAMP via G protein-coupled secretin receptors, which are expressed in the brain, pancreas, stomach, kidney, and liver. GHRHR is a specific receptor for the growth hormone-releasing hormone (GHRH) that controls the synthesis and release of growth hormone (GH) from the anterior pituitary somatotrophs. Mutations in the gene encoding GHRHR have been connected to isolated growth hormone deficiency (IGHD), a short-stature condition caused by deficient production of GH or lack of GH action. VIP and PACAP exert their effects through three G protein-coupled receptors, PACAP-R1, VIP-R1 (vasoactive intestinal receptor type 1, also known as VPAC1) and VIP-R2 (or VPAC2). PACAP-R1 binds only PACAP with high affinity, whereas VIP-R1 and -R2 specifically bind and respond to both VIP and PACAP. VIP and PACAP and their receptors are widely expressed in the brain and periphery. They are upregulated in neurons and immune cells in responses to CNS injury and/or inflammation and exert potent anti-inflammatory effects, as well as play important roles in the control of circadian rhythms and stress responses, among many others. All B1 subfamily GPCRs are able to increase intracellular cAMP levels by coupling to adenylate cyclase via a stimulatory Gs protein. However, depending on its cellular location, some members of subfamily B1 are also capable of coupling to additional G proteins such as G(i/o) and/or G(q) proteins, thereby leading to activation of phospholipase C and intracellular calcium influx.

Feature 1 # # # ## # # # AAA87556 139 LLKLKVMYTVGYSSSLVMLLVALGILCAFRR.[5].NYIHMHLFVSFILRALSNFIKDAVL.[15].CKLVMVLFQYCIM 227 human AFM84635 137 FHTVKILYTCGYAASLTALVTAISIFSLFRK.[5].NFIHVNLFVSFILRGIAVFIKDAVL.[15].CKAAVVFFQYSVL 225 African clawed frog Q91085 138 YGTVKTGYTIGHTLSLIALTAAMIILCLFRK.[5].NYIHMHLFMSFIMRAIAVFIKDVTL.[15].CKAMMVFFQYCVM 226 turkey AAZ30048 123 FSTIKIIYTVGYSLSITSLIIAVTVLMAFRR.[5].NYIHIQLFFTFILKAIAIFIKDSVL.[15].CKISVVFCHYFMM 211 chicken P41587 123 YILVKAIYTLGYSVSLMSLATGSIILCLFRK.[5].NYIHLNLFLSFILRAISVLVKDDVL.[18].CKLSLVFLQYCIM 214 human P70205 150 YLSVKALYTVGYSTSLVTLTTAMVILCRFRK.[5].NFIHMNLFVSFMLRAISVFIKDWIL.[15].CKAVMVFFHYCVV 238 house mouse

Feature 1 ## # # AAA87556 228 ANYSWLLVEGLYLHTLLA.[7].KYLQGFVAFGWGSPAIFVALWAIAR.[7].CWD.[3].NASIWWIIRGPVILSILIN 309 human AFM84635 226 ANFSWLLVEGMYLHTLLT.[7].KYFWWYIVIGWGAPALTVSVWIKTR.[7].CWD.[2].ESIYWWIIKTPILLAIFIN 306 African clawed frog Q91085 227 ANFFWLLVEGLYLHTLLV.[7].KYFWWYILIGWGAPSVFITAWTVVR.[7].CWE.[3].ESPIWWIIKTPILVSILVN 308 turkey AAZ30048 212 TNFIWLLVEALYLNCLLL.[7].RYFWWLVLFGWGFPTLFTFIWILAK.[7].CWD.[3].DSPYWWLIKGPIIISVGVN 293 chicken P41587 215 ANFFWLLVEGLYLHTLLV.[6].RCFLAYLLIGWGLPTVCIGAWTAAR.[7].CWD.[3].HSVPWWVIRIPILISIIVN 295 human P70205 239 SNYFWLFIEGLYLFTLLV.[7].RYFYWYTIIGWGTPTVCVTVWAVLR.[7].CWD.[3].STALWWVIKGPVVGSIMVN 320 house mouse

Feature 1 # # # # AAA87556 310 FILFINILRILMRKLR.[10].HYKRLARSTLLLIPLFGIHYIVFAFSPE.[2].MEIQLFFELALGSFQGLVVAVLYCF 390 human AFM84635 307 FIIFLNVIRILIQKIR.[10].QYMRLAKSTLLLIPLFGVHYVIFALFPE.[3].IWARMYFELVLGSNQGFIVALLYCF 388 African clawed frog Q91085 309 FILFICIIRILVQKLH.[10].QYSRLAKSTLLLIPLFGIHYIMFAFFPD.[3].AQVKLVFELVVGSFQGFVVAVLYCF 390 turkey AAZ30048 294 FVLFINIIRILLKKLD.[10].QYRRLSRSTLLLIPLFGTHYIVFNFLPE.[3].LGIRLYLELCIGSFQGFIVALLYCF 375 chicken P41587 296 FVLFISIIRILLQKLT.[10].QYKRLAKSTLLLIPLFGVHYMVFAVFPI.[3].SKYQILFELCLGSFQGLVVAVLYCF 377 human P70205 321 FVLFIGIIIILVQKLQ.[38].ITLRLARSTLLLIPLFGIHYTVFAFSPE.[3].KRERLVFELGLGSFQGFVVAVLYCF 430 house mouse

Feature 1 AAA87556 391 LN.[1].EVQLEVQKKWQQ 405 human AFM84635 389 LN.[1].EVQAEIQRHWGK 403 African clawed frog Q91085 391 LN.[1].EVQAELKRKWRR 405 turkey AAZ30048 376 LN.[1].EVQTEIGRRWHG 390 chicken P41587 378 LN.[1].EVQCELKRKWRS 392 human P70205 431 LN.[1].EVQAEIKRKWRS 445 house mouse

Conserved Protein Domain Family7tmB1_Secretin_R-like

Conserved Protein Domain Family
7tmB1_Secretin_R-like