2LM3


Conserved Protein Domain Family
SPRY_PRY_TRIM5_6_22_34
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cd15810: SPRY_PRY_TRIM5_6_22_34 
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PRY/SPRY domain of tripartite motif-binding protein 5, 6, 22 and 34 (TRIM5, TRIM6, TRIM22 and TRIM34)
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of very close paralogs, TRIM5, TRIM6, TRIM22 and TRIM34. These domains are composed of RING/B-box/coiled-coil core and are also known as RBCC proteins. They form a locus of four closely related TRIM genes within an olfactory receptor-rich region on chromosome 11 of the human genome. Genetic analysis of this locus indicates that these four genes have evolved by gene duplication from a common ancestral gene. All genes in the TRIM6/TRIM34/TRIM5/TRIM22 locus are type I interferon inducible, with TRIM5 and TRIM22 possessing antiviral properties. TRIM5 promotes innate immune signaling by activating the TAK1 kinase complex by cooperating with the heterodimeric E2, UBC13/UEV1A. It also stimulates NFkB and AP-1 signaling, and the transcription of inflammatory cytokines and chemokines, amplifying these activities upon retroviral infection. Interaction of its PRY-SPRY or cyclophilin domains with the retroviral capsid lattice stimulates the formation of a complementary lattice by TRIM5, with greatly increased TRIM5 E3 activity, and host cell signal transduction. TRIM6 is selectively expressed in embryonic stem (ES) cells and interacts with the proto-oncogene product Myc, maintaining the pluripotency of the ES cells. TRIM6, together with E2 Ubiquitin conjugase (UbE2K) and K48-linked poly-Ub chains, is critical for the IkappaB kinase epsilon (IKKepsilon) branch of type I interferon (IFN-I) signaling pathway and subsequent establishment of a protective antiviral response. TRIM22 plays an integral role in the host innate immune response to viruses; it has been shown to inhibit the replication of a number of viruses, including HIV-1, hepatitis B, and influenza A. Altered TRIM22 expression has also been associated with multiple sclerosis, cancer, and autoimmune disease. While the PRY-SPRY domain of TRIM5a provides specificity and the capsid recognition motif to retroviral restriction, TRIM34 binds HIV-1 capsid but does not restrict HIV-1 infection.
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Statistics
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PSSM-Id: 293982
Aligned: 7 rows
Threshold Bit Score: 302.477
Created: 12-Nov-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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2LM3_A        13 DVTLATNNIS.[1].AVIAED.[1].RQVSSR.[24].TGVLGSQSI.[1].SGKHYWEVDVS.[4].WILGVCAGFQ 95  rhesus monkey
ACK77570     302 DVTLDPHTAN.[2].LILSKN.[1].RQMRFV.[15].CSVLGSQHF.[1].SGKYYWEVDVT.[4].WILGVCSHSV 376 rabbit
NP_001192122 302 DITLNPVNLN.[2].LILSED.[1].RQVTSV.[ 9].YGILGSRYF.[1].SGKHYWEIDVS.[4].WILGVYCRTR 370 horse
ELV13803     269 DVMLNPVNTV.[2].VVISAD.[1].RQVKVV.[15].FGVLGCQYF.[1].SGRYYWEVDVS.[4].WILGVHSKRN 343 Chinese tree shrew
XP_005612150 301 NVTLRPTSSS.[1].IVISAD.[1].RRVRIM.[15].FDAVGLQSF.[1].SGKFYWEVDVS.[4].WILGVCNHKF 374 horse
XP_007954388 310 TPFLSPVIIV.[4].VAISYD.[1].RQARIV.[10].YGVMGCLYI.[1].SGKHYWEVDVS.[4].WVLGVYDYKI 381 Orycteropus afer afer
XP_006870390 303 DMTLIPMNSS.[2].IVISED.[1].KQARVE.[34].NPIRGSLCI.[1].SGKHYWEVNVS.[4].WILGVCCVRR 396 Cape golden mole


2LM3_A        96 .[14].PKYGYWVIGL.[5].YSVF.[13].VPLS.[6].RVGVFVDYE.[1].CTVSFFNI.[3].GFLIYKFSQ 181 rhesus monkey
ACK77570     377 .[20].PQNGYWVIGL.[5].YRAY.[ 6].LLLS.[6].RIGVFLDYE.[1].GTVSFYNV.[3].GFPIYTFSK 461 rabbit
NP_001192122 371 .[22].PQYGYWVIGL.[5].YNAF.[10].LTLS.[6].HVGVFLDCE.[1].GTVSFFNV.[3].GSLIYKFSK 461 horse
ELV13803     344 .[27].PQNGYWVIGL.[5].YNAF.[ 9].LTLS.[6].RIGVFLDCE.[1].GIVSFFNV.[3].GSLIYKFSK 438 Chinese tree shrew
XP_005612150 375 .[25].PRAGCWVIGL.[5].YNAF.[10].LTLS.[6].RVGVFLDYE.[1].GSVSFFNV.[3].GSLIYKFSK 468 horse
XP_007954388 382 .[18].PQNGYWVIGL.[5].YRAF.[10].LFLS.[6].CVGVFLDYE.[1].RTVSFFNV.[2].PGFIYKFSK 467 Orycteropus afer afer
XP_006870390 397 .[22].PQYGYWVIGL.[5].CTAF.[10].LVLF.[6].HVGVFIDYE.[1].RTVSFFNV.[3].GSLMYKFSN 487 Cape golden mole


2LM3_A       182 .[5].PVFPYLNP.[4].VPMTLC 204 rhesus monkey
ACK77570     462 .[5].NVCPYFNP.[4].VPMTLR 484 rabbit
NP_001192122 462 .[5].TAYPYFNP.[4].APMTLC 484 horse
ELV13803     439 .[5].PTYPYFNP.[4].GPMTLC 461 Chinese tree shrew
XP_005612150 469 .[5].AVCPYFNP.[4].RPIILC 491 horse
XP_007954388 468 .[5].TVCPYFHP.[4].VPMSLC 490 Orycteropus afer afer
XP_006870390 488 .[5].TVCPYFNL.[4].NPMSLC 510 Cape golden mole
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