3PBL


Conserved Protein Domain Family
7tmA_D2-like_dopamine_R
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cd15053: 7tmA_D2-like_dopamine_R 
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D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.
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Statistics
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PSSM-Id: 320181
Aligned: 11 rows
Threshold Bit Score: 305.039
Created: 13-Nov-2008
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:3PBL: Human dopamine D3 receptor in complex with a D2/D3 selective antagonist (eticlopride), contacts at 4A.
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Sequence Alignment
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Feature 1                                                                                        
3PBL_A        39 AYYALSYCALILAIVFGNGLVCMAVLKERA.[4].TNYLVVSLAVADLLVATLVMPWVVYLEV.[4].WNFS.[3].CDV 114
XP_001087197  31 AAALVGGVLLIGAVLAGNSLVCVSVATERA.[4].TNSFIVSLAAADLLLALLVLPLFVYSEV.[4].WLLS.[3].CDA 106 Rhesus monkey
EMC78343      45 NYYAMLLTLLIFVIVFGNVLVCMAVSREKA.[4].TNYLIVSLAVADLLVATLVMPWVVYLEV.[3].WRFS.[3].CDI 119 domestic pigeon
XP_002731088  31 NYWSLFIILFSLVTVFGNVLVCLAVFREKS.[4].TNYFIVSLAVADLSVGLLVMPVAIYVEI.[4].WYLG.[3].CDF 106 Saccoglossus kowalev...
CCD58583      71 QYWAMILLIFPLFTVFGNVLVVLSVFRDQS.[4].TNYFIVSLAIADISLAIVVMPVASWVEA.[4].WRLG.[3].CDI 146 Schistosoma mansoni
Q8IS44        77 NYWALILILFPILTLFGNILVILSVCRERS.[4].TNYFIVSLAIADLLVAVVVMPFAVYFLV.[3].WALP.[3].CDF 151 fruit fly
ABI64137     123 NYWTLLLLLFPVFTVFGNILVLMSVYRERS.[4].TNYFIVSLALADLLLASIVMPFAVYYLL.[4].WGLG.[3].CDL 198 California spiny lob...
Q6RYS9        22 VAAGVFLPLVPTMAVFGNVLVIMSVFRERS.[4].TNMLIVSLAVSDFMVAIGVMSFGVYYEW.[4].WGLG.[3].CHV 97  nematode
NP_001024048  38 NYAGLSLIVIPLITLLGNLLVIISVLRYRA.[4].INFLILGLAVADLLVAIIVMPYAVYVYV.[4].WYLG.[3].CDI 113 nematode
AFC88981     111 VYWALMLVILPFLAVFGNILIILSVYKERS.[4].TNYFIVSLAFADLLVAAAVMPFAVYVLV.[3].WELS.[3].CDF 185 southern cattle tick
EFV59979      39 HFYALALLIIPSLTIFGNVLVIASVCRFRN.[4].INYFIFGLAIADLMVAVLVMPFAVYVEF.[4].WELG.[3].CDL 114 Trichinella spiralis


Feature 1        #   ##  #                                                              #        
3PBL_A       115 FVTLDVMMCTASIWNLCAISIDRYTAVVMP.[11].CRRVALMITAVWVLAFAVSCPLLFGF.[ 7].VCSI.[1].NPD 196
XP_001087197 107 LMAMDVMLCTASIFNLCAISVDRFVAVAVP.[ 8].SHRQLLLIGATWLLSAAVAAPVLCGL.[ 9].VCRL.[1].DRD 187 Rhesus monkey
EMC78343     120 FVTLDVMMCTASILNLCAISIDRYTAVAMP.[ 9].KRRVTVMIAVVWVLSFAISCPLLFGL.[ 6].ECII.[1].NPA 198 domestic pigeon
XP_002731088 107 WVTMDVMSCTASIFNLCAISLDRLYAVSKP.[ 8].TQRALVTIAIVWMISFIISCPVLFGV.[ 9].LCIL.[1].NGP 187 Saccoglossus kowalev...
CCD58583     147 FIMFDVLLCTASILNLAAISMDRYVAVTRP.[ 8].NVRVGITITVTWILSFVIALPIACGL.[ 9].ICVM.[1].IPE 227 Schistosoma mansoni
Q8IS44       152 YIAMDVICSTSSIFNLVAISIDRYIAVTQP.[ 8].SRRVCLTILLVWAISAAIGSPIVLGL.[ 9].VCAF.[1].NAD 232 fruit fly
ABI64137     199 YIAMDVVCSTSSIFNLVAISIDRYIAVTQP.[ 8].NKRIVFTIAIIWVVSAAIGIPLFFVN.[13].DCNF.[1].NAD 283 California spiny lob...
Q6RYS9        98 YQALDVACSTASILNLLAISLDRYIAIGHP.[ 9].GGRAMISITIVWGVSVAVALPLLLGV.[ 9].ECEL.[1].NPY 179 nematode
NP_001024048 114 YMASDVCCSTASILLLAVISFDRYRAVSLP.[ 9].VKRVWTLIAVIWLVSLTLASPMVFGV.[10].ECRF.[1].NAE 196 nematode
AFC88981     186 YIAVDVTCSTASIFNLVAISIDRFIAVTQP.[ 8].SKRVALTIVIVWVVSAAIGSPIMLGL.[ 9].LCIF.[1].NSD 266 southern cattle tick
EFV59979     115 YCAADVVCSTASIILLTVIGFDRYIAANHP.[ 9].VKYVVTINISVWAVSALIACPLVLGL.[ 9].ECRF.[1].NAD 196 Trichinella spiralis


Feature 1         #  ##                                                    ##  #             #   
3PBL_A       197 FVIYSSVVSFYLPFGVTVLVYARIYVVL.[169].LREKKATQMVAIVLGAFIVCWLPFFLTHVLN.[ 8].SPELYSAT 440
XP_001087197 188 YVVYSSVCSFFLPCPLMLLLYWATFRGL.[132].GRERKAMRVLPVVVGAFLLCWTPFFVVHITQ.[ 8].PPRLVSAV 394 Rhesus monkey
EMC78343     199 FVVYSSIVSFYVPFIVTLLVYVQIYIVL.[152].QKEKKATQMLAIVLGVFIICWLPFFITHILN.[ 7].PPAMYSAF 424 domestic pigeon
XP_002731088 188 YMVWSSVFSFVIPAFIMSIVYILVYVAI.[ 84].RRERKATKTLAIVLGVFLICWIPFFTLNILF.[ 7].APHTSSRA 345 Saccoglossus kowalev...
CCD58583     228 YIIASSIGSFYVPCTIMIVLYYQVFKAI.[344].KREKKATKTLAIVLGVFLFCWMPFFTNNIIQ.[17].PDCITSIC 655 Schistosoma mansoni
Q8IS44       233 FILYSSLSSFYIPCIIMVFLYWNIFKAL.[162].KKERKATKTLAIVLGVFLFCWLPFFSCNIMD.[12].GLTAYMMT 473 fruit fly
ABI64137     284 FILYSSISSFYIPCIAMIYLYYRIFKAL.[205].KKERKATKTLAIVLGAFLVCWVPFFTCNIVN.[13].GMAIFVLT 568 California spiny lob...
Q6RYS9       180 FNMISSIFSFFIPCIAMIILYTIIFRRL.[310].RREHKATVTLAVVLAVFLFCWLPFFVLHLSN.[13].GFLPLYLA 569 nematode
NP_001024048 197 FSILSSMISFVIPCFLVLFVYIRIIIAL.[517].RKEKRATKTLGVVVGVFLVCWVPFFVINILN.[13].GYDLFFYC 793 nematode
AFC88981     267 FILYSSLSSFYIPCLVMVFLYYKIFRVI.[218].KRERKATKTLAIVLGVFLICWVPFFTCNVVD.[13].GVTVFLLT 564 southern cattle tick
EFV59979     197 FIIYSSIISFWIPMIVMLYFFACTYLQI.[305].RNEKKATKTLSIVLGIFLACWLPFFTLNMLN.[13].GFMPFFLT 581 Trichinella spiralis


Feature 1        #   #                        
3PBL_A       441 TWLGYVNSALNPVIYTTFN.[2].FRKAF 466
XP_001087197 395 TWLGYVNSALNPVIYTVFN.[2].FRNVF 420 Rhesus monkey
EMC78343     425 TWLGYVNSAVNPIIYTTFN.[2].FRKAF 450 domestic pigeon
XP_002731088 346 LFLGYINSTMNPIIYTVFN.[2].FRRAF 371 Saccoglossus kowalevskii
CCD58583     656 VWLGYVNSVLNPIIYTIFN.[2].FRKAF 681 Schistosoma mansoni
Q8IS44       474 TWLGYINSFVNPVIYTIFN.[2].FRKAF 499 fruit fly
ABI64137     569 TWIGYMNSFLNPVIYTIFN.[2].FRKAF 594 California spiny lobster
Q6RYS9       570 TWLGYLNSSLNPLIYTVFD.[2].FRNAF 595 nematode
NP_001024048 794 TWIGYMNSFMNPIIYTIFN.[2].FRRAF 819 nematode
AFC88981     565 TWLGYVNSCVNPVIYTIFN.[2].FRKAF 590 southern cattle tick
EFV59979     582 TWLGYMNSFMNPIIYTLFN.[2].FRKAF 607 Trichinella spiralis

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