Conserved Protein Domain Family
NHL_TRIM32_like

?
cd14961: NHL_TRIM32_like 
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins
The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Statistics
?
PSSM-Id: 271331
Aligned: 27 rows
Threshold Bit Score: 239.1
Created: 21-Mar-2014
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
  next features
Feature 1:NHL repeat [structural motif]
Evidence:
  • None

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Feature 1                        #######     #####################     #######                    
Q8CH72        364 GAKGS.[2].GMFNLPVSLYVT.[1].QSEVLVADRGNYRIQVFNRKG.[5].RRSPSGIDS.[13].TPLSVAMNCHGL 443  house mouse
NP_001107066  371 GCKGN.[2].GMFNLPVSICVT.[1].QGEVLVADRGNYRIQIFNRKG.[5].RRNPSSIDN.[13].IPLSIAITAQGL 450  zebrafish
XP_002740390  592 GRTGV.[2].AEFNIPIGVTVD.[1].KGNVLVADAANKRIQILESNG.[1].YIDQIRVDI.[ 1].HTSGVAMAPNDN 655  Saccoglossus kowal...
XP_006825513  782 GRTGV.[2].EEFNIPIDVSVN.[1].KGNVLVADAGNKRIQILDSNG.[1].YIGHILVDL.[ 1].HISGVAMAPNGN 845  Saccoglossus kowal...
ESO91335      419 GSRGS.[2].DNLNQPVRIASG.[1].NGLIFVLDTGNSRIKIINSDG.[4].HIGPIGLEN.[ 1].SATGLCLMNEGN 485  owl limpet
XP_002741510  476 LTVGD     GKLSEPNGVVVN.[2].TGTLYVTDSRDKKVVTLSLDD.[2].DISEFNLPF.[ 1].QLYDITLDHDGN 539  Saccoglossus kowal...
XP_006561120  446 GRRGN.[2].DEFHQPVAVAVD.[1].DGMIYILDTGNSRIKVLNYDL.[4].HITNEGLEG.[ 1].SCTGIGISQQGI 512  honey bee
XP_005113065  218 GSRGT.[2].EQLNQPVRIAAG.[2].GDVVYVLDTGNSRIVVLGRDG.[4].HLGPAGVEQ.[ 1].SATGLSVMSSGQ 285  California sea hare
XP_005746304  605 GKQGS.[2].ADLTLPSGIHAT.[1].QGQLFIVDCGNARIQVTDARG.[5].VTSPTAGGS.[ 5].NYFDIAVNAKGL 676  Pundamilia nyererei
XP_002733628  395 GKRGS.[2].GEFCDPEGVAVT.[1].AGDIVVADKGNSRLQIFDSLG.[3].FQSPAHMYK      TPTDVAVNPDND 459  Saccoglossus kowal...

Feature 1                                                                                         
Q8CH72        444 IGVTD.[1].YDNSLKVYTMDGH.[1].VACHRSQL.[1].KPWGITALPS     GQFVVTD.[1].EGGKLWCFTVDR 502  house mouse
NP_001107066  451 IGVTD.[1].YDNSVKVYTTDGH.[1].IACHKNQL.[1].KPWGIAAMPS     GQFVVSD.[1].EGGKLWCLAVDR 509  zebrafish
XP_002740390  656 IVVVE.[1].ETRHVHIYNENRK.[3].HFTYKEFV     KPFGITVNSK     GHILVAD.[1].GASYIFVFTSDG 715  Saccoglossus kowal...
XP_006825513  846 IVVVE.[1].ETKHVHVYNENRE.[3].QFTYKEFV     KPYGITVNSK     GHILVAD.[1].EASYIFMFTSDG 905  Saccoglossus kowal...
ESO91335      486 LAVIN.[1].RSKQVSIITPEGE.[3].QFTTTEFV     EPTDIAVNSR     GEIIVAD.[1].GASKIFIFGSAG 545  owl limpet
XP_002741510  540 LVLSE.[1].ETNSVHIYSTDGE.[2].LTVENDQM.[1].KPVGVAVDRE     SNILVAD.[1].EANCIFVFDRRG 599  Saccoglossus kowal...
XP_006561120  513 VVVNW     RTRKITEMSSLGD.[3].SFSHNAFQ     EPIDVAVDRS.[1].GHILVAD.[1].GQSCVFVFDSDG 572  honey bee
XP_005113065  286 LVVIN.[1].RSKMVSVLSPEDG.[4].SFTTPGFV     EPIDVAVNSR     GEVVVAD.[1].GAKKIFKFDTSG 346  California sea hare
XP_005746304  677 IAVSC.[1].AERALLVFSRHGR.[3].TFGGSGFS.[7].APRGVTVTRL     DEFLVAD.[1].RKGTLIALKLDP 743  Pundamilia nyererei
XP_002733628  460 FVVVD.[1].GLRCIRITSPDKC.[1].VTIRKTDS.[2].SPKSPVDDDF     WNYLHGI     TVDRIGHVVVSS 518  Saccoglossus kowal...

Feature 1                                                                                         
Q8CH72        503 .[3].VVKYSCLCS     AVRPKFVTCDA.[1].GTVYFTQ.[11].EHHLEGGFS.[2].SVGPDGQLGRQ.[12].C 579  house mouse
NP_001107066  510 .[3].VVNYNRLCS     AVRPKFVTCDS.[1].GTVYFTQ.[11].EHHLEGGFS.[2].SVGMDGQLGKQ.[12].C 586  zebrafish
XP_002740390  716 .[3].MKIGEDVGE.[2].LYQPAFVVATR.[1].NDVIVSD.[ 1].KHGLKFFTE.[3].YIHGIHQIGDD.[ 4].D 777  Saccoglossus kowal...
XP_006825513  906 .[5].IGKEEGEGK     LNNPHFVATGR.[1].DDVIVSD.[ 1].RHGLALFTQ.[3].FKRGIHQIGDD.[ 4].D 967  Saccoglossus kowal...
ESO91335      546 .[1].LITTFGSKG     IKDGQFKLISS     VTVGKCD.[ 5].DHRIQVFSK.[3].FSRCLSDSGKG      Q 602  owl limpet
XP_002741510  600 .[5].IGSGGDKPD.[1].LKDISFIALDR.[1].GNIHVSN.[ 2].HQRITVYTG.[3].FLRNISVSGHG.[ 5].N 664  Saccoglossus kowal...
XP_006561120  573 .[2].LFQVGKRST     FKLITSVTVGP     NGEIIVA      DSRIQVFSA.[3].FSEEIYSEGKG.[ 2].T 627  honey bee
XP_005113065  347 .[5].FGSHGDKDG.[1].FKVISGLCVGK.[1].DEILVAD.[12].SRKLVDPGS.[3].GGIAVDSAGNV.[14].S 430  California sea hare
XP_005746304  744 .[4].RLERTVVTG     FHRPYLVAACL.[2].GMVAVSE.[ 4].TGRVPCVKV.[3].GWNTVRVFGVC.[ 8].C 812  Pundamilia nyererei
XP_002733628  519      SCHEQSHIR     VFTPYGTEICR.[1].GEKDKLD.[10].NENILVSNH.[3].PLRKYDIRGRE.[ 9].F 589  Saccoglossus kowal...

Feature 1                                                                                         
Q8CH72        580 IAGMCVDARG.[1].LIVADSSR.[ 1].EILHFPK.[1].GGYSVLIR.[1].GLTCPVGIALT.[1].KGQLLVLDCW 638  house mouse
NP_001107066  587 ITGMCVDSNG.[1].LIVTDSGR.[ 1].EILQFPK.[1].GGYNILIQ.[1].GLTCPVGVAVT.[1].KGQLLVLDCW 645  zebrafish
XP_002740390  778 CSGVAVDSDY.[1].IIVADRAS.[ 3].RILVLTY.[2].SVIQSLES.[3].KLSRPHGVAVT.[1].DGYVIVADYG 841  Saccoglossus kowal...
XP_006825513  968 SNGVAVDSHY.[1].IVVADQGS.[ 3].RILVLTY.[2].TVIQCLES.[3].KLSSPHGVAVT.[1].DGYVIVADAN 1031 Saccoglossus kowal...
ESO91335      603 YGGIVVDNGG.[1].LLATKTEK.[ 5].QVMIMNS.[2].KLHNIIDS.[3].KLKRPSGIAIL.[1].NFHVVVADLG 668  owl limpet
XP_002741510  665 PTGIASASGL     LFVADDAD      DVIQIYT.[1].EGAFVAKL.[5].VLSGPQGVSIT.[1].DGSIAVVDRG 725  Saccoglossus kowal...
XP_006561120  628 YGGLAVDAEG.[1].ILGTRTDK.[ 2].SIIQVLK.[1].GGGNILTE.[6].KLRRPSGIAVL.[1].DNHLVVVDLG 692  honey bee
XP_005113065  431 GAGPSSSSSS.[2].SSAKEKGS.[11].SFVHVFH     SNGKLLYS.[6].RLRRPSGLAVL.[1].DYRIVVADLG 504  California sea hare
XP_005746304  813 PWGICIDPDG.[1].VLVADWGE.[ 2].RILLYPA.[2].VGWPIINQ     GLSSPRGLSLL.[1].DGQLAVSDSM 872  Pundamilia nyererei
XP_002733628  590 ITGICCDDLD.[1].MLTVSYRT.[ 1].QILLVHK.[2].TPGGILAE     GLSHPEGIAFT.[1].DKKLVVVDGG 648  Saccoglossus kowal...

Feature 1                 
Q8CH72        639 DHCVKIYS 646  house mouse
NP_001107066  646 DHCVKVYT 653  zebrafish
XP_002740390  842 NDCIKKYK 849  Saccoglossus kowalevskii
XP_006825513 1032 NDCIKKYK 1039 Saccoglossus kowalevskii
ESO91335      669 NDCVKKYR 676  owl limpet
XP_002741510  726 NQCVKMYQ 733  Saccoglossus kowalevskii
XP_006561120  693 NDCIKKYR 700  honey bee
XP_005113065  505 NNCVKKFY 512  California sea hare
XP_005746304  873 HHCIKIYQ 880  Pundamilia nyererei
XP_002733628  649 HNRVKVYQ 656  Saccoglossus kowalevskii

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap