3ZGW


Conserved Protein Domain Family
STKc_MELK

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cd14078: STKc_MELK 
Click on image for an interactive view with Cn3D
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270980
Aligned: 13 rows
Threshold Bit Score: 528.492
Created: 9-Aug-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 20 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Structure:3ZGW: Human MELK binds AMP-PNP; contacts at 4A.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                  ## #### #            # #               #                    #        
3ZGW_A         8 LLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDK.[2].LGSDLPRIKTEIEALKNL.[1].HQHICQLYHVLET 79  human
AAH50520       9 LLRHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEK.[2].LGDDLPRVKIEIEAMKNL.[1].HQHVCRLYHVIET 80  zebrafish
NP_001026680   9 ILKYYELHETIGTGGFAKVKLGRHLLTGEKVAIKIMDK.[2].LGDDLPRVKTEIDAMKNL.[1].HQHVCRLYHVIET 80  chicken
CAA78913       9 LLKYYELHETVGTGGFAKVKLASHLITGEKVAIKIMDK.[2].LGDDLPRVKTEIDAMKNL.[1].HQHVCRLYHVIET 80  African clawed frog
XP_395000      7 LKGLYDLEKTIGSGGFAKVKLATHIATGEKVAIKIMDK.[2].LGDDLPRVKLEVQALKTL.[1].HQHICRLYQVIET 78  honey bee
XP_781767     29 IKHRYHLKETIGSGGFAKVKLATHLLSGQKVAIKIMDK.[2].LGDDLPRVKTEIKAMKEL.[1].HQHICTLYEVVET 100 purple sea urchin
XP_002613742   8 IQEYYQLRHTIGSGGFAKVKLAHHILTGEKVAVKIMDK.[2].LGPDLPRVQIEIEAMKTL.[1].HQHVCKLYQVLET 79  Florida lancelet
EFX88933      10 LDGFYEMYDTIGSGGFAKVKLGVHCLTGEKVAIKIMDK.[2].LGDDLPRIRLEIEAMKSL.[1].HQNVCKLFQVIET 81  common water flea
XP_001636502  10 LSKYYDVRETIGSGGFAKVKLAVHRTSGEKVAIKMMNK.[2].LGHDLPRVQRELEAMKDL.[1].HQHICQLYHVIET 81  starlet sea anemone
CBY32973       8 IKKRYLVKETIGSGGFGKVKRALHIATTETVAIKVMDK.[2].LGADLPRVKTEIKALRTL.[1].HPHICRLYEEIET 79  Oikopleura dioica
XP_002115270   5 VCDYYQVRETIGSGGFAQVKIAKHRLSGETVAIKVMNK.[2].LGEDLPRVQREINALRSL.[1].HQHISQMYQVIDT 76  Trichoplax adhaerens
NP_001023421   7 LQGFYAVHDELGSGGFGKVRLATHLLTNQKVAIKIIDK.[2].LGHDLPRVQTEMDALRNL.[1].HQNICRLYHYIET 78  nematode
XP_003389642  18 VEENYELFETLGSGGFAKVKLGKHKLTGEKVAVKIMNK.[2].LGDDLPRVYREMRALKNL.[1].HQHVCQLFEVIET 89  Amphimedon queenslandica

Feature 1                    ###       #                                              ## #   
3ZGW_A        80 .[1].NKIFMVLEYCP.[1].GELFDYIIS.[1].DRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDE 143 human
AAH50520      81 .[1].SKIYMVLEYCP.[1].GELFDYIIA.[1].DRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLLIDE 144 zebrafish
NP_001026680  81 .[1].KKIFMVLGYCP.[1].GELFDYIVS.[1].DRLSEEEARVFFRQIVSAIAYVHSQGYAHRDLKPENLLIDE 144 chicken
CAA78913      81 .[1].KKIFMVLEYCP.[1].GELFDYIIA.[1].DRLTEEEARVFFRQIVSAVAYIHSQGYAHRDLKPENLLIDE 144 African clawed frog
XP_395000     79 .[1].SHYFMVIEYCS.[1].GELFDHIVE.[1].NKLSETESRKFFRQIVSAVAYLHSLGYAHRDLKPENVLLDK 142 honey bee
XP_781767    101 .[1].NKIFMVIEFCP.[1].GELFDYIVA.[1].DRLKEAEARGFFRQIIAAVAFIHNEGYAHRDLKPENLLLDE 164 purple sea urchin
XP_002613742  80 .[1].TKIFMVLEYCP.[1].GELFDYIVA.[1].DRLPEEEARVFFRQIVSAVAYIHTEGYAHRDLKPENLLLDE 143 Florida lancelet
EFX88933      82 .[1].AKIFMVLEYCP.[1].GELFDYIVE.[1].DRLTEDEARHFFRQIVAAVAYIHHKGFAHRDLKPENLLLDD 145 common water flea
XP_001636502  82 .[1].ENIYMVLEYAQ.[1].GELFDYIVA.[1].DRLKEDEARGFFRQIISAVAYIHEKGYAHRDLKPENLLLDE 145 starlet sea anemone
CBY32973      80 .[1].NKIFLVLEHCS.[1].GELFDYIVE.[1].DRLNEDEARQFFREICAAVAYMHSKGFAHRDLKPENILIDE 143 Oikopleura dioica
XP_002115270  77 .[1].DDIYIVMEYVP.[1].GEVFDYIVT.[1].DRLLEDEARKFFRQVISAIAYVHNEGFAHRDLKPENLLLDR 140 Trichoplax adhaerens
NP_001023421  79 .[1].DKFFIVMEYCS.[1].GEMFDYIVR.[1].ERLEESEARHFFRQLVSAIAFVHSQGYAHRDLKPENLLLTE 142 nematode
XP_003389642  90 .[1].LMIYMILEYCS.[1].GELFDYIVA.[1].EKLKEPEARTFFRQIVAALKYVHTSGFIHRDLKPENLLLDE 153 Amphimedon queenslandica

Feature 1                  ##                                                                    
3ZGW_A       144 .[1].HKLKLIDFGLCAKPKGN.[1].DYHLQTCCGSLAYAAPELIQGKSY.[1].GSEADVWSMGILLYVLMCGFLPFD 211 human
AAH50520     145 .[1].HNLKLIDFGLCAKPKGG.[1].GFELLTCCGSPAYAAPELIQGKAY.[1].GSEADVWSMGVLLYALLCGFLPFD 212 zebrafish
NP_001026680 145 .[1].HNLKLIDFGLCAKPKGG.[1].DYRLNTCCGSPAYAAPELIQGKAY.[1].GSEADIWSMGVLLYALLCGFLPFD 212 chicken
CAA78913     145 .[1].QNLKLIDFGLCAKPKGG.[1].DYHLMTCCGSPAYAAPELIQGKAY.[1].GSEADIWSMGVLMYALMCGYLPFD 212 African clawed frog
XP_395000    143 .[1].ENLKLIDFGLCAKPKNG.[1].DSHLQTSCGSPTYAAPELILGKKY.[1].GSEVDIWSMGVLLYALLCGFLPFD 210 honey bee
XP_781767    165 .[1].QSLKLIDFGLAAKPKGG.[1].KDHLETCCGSPAYAAPELVSGKEY.[1].GSEADIWSMGVLLYALLCGFLPFD 232 purple sea urchin
XP_002613742 144 .[1].HNLKLIDFGLCAKPKGG.[1].DHQLSTCCGSPAYAAPELIQGDEY.[1].GAEADVWSMGVLLYALMCGFLPFD 211 Florida lancelet
EFX88933     146 .[1].QQLKLIDFGLCAKPKGG.[1].NSHLETCCGSPAYAAPELISGKCY.[1].GSEADIWSMGVLLYALLCGYLPFD 213 common water flea
XP_001636502 146 .[1].QNIKLIDFGLVAKPEGG.[1].TEQLETCCGSPAYAAPELISGLPY.[1].GNEVDLWSMGVLLYALVCGFLPFD 213 starlet sea anemone
CBY32973     144 .[1].HRIKLIDFGLCANPDAG.[1].ESALATCCGSPAYAAPELVSGRKY.[1].GPEADVWSLGVLLYALLNGFLPFD 211 Oikopleura dioica
XP_002115270 141 .[1].QNIKLIDFGLVAKPQSL     QDNLYTCCGSPAYAAPELIAGKPY.[1].GSKADIWSMGILLYALLCGYLPFD 207 Trichoplax adhaerens
NP_001023421 143 .[1].LHLKLIDFGLCAKTEKG.[3].KHNLDTCCGSPAYAAPELIQGLQY.[1].GNEADVWSMGILLYTLLVGALPFE 212 nematode
XP_003389642 154 .[1].SNIKLIDFGLVAEPKDI     RHLLKTCCGSPAYAAPELIKGGPY.[1].GPRADVWSLGVLLYALLNGFLPFD 220 Amphimedon queenslan...

Feature 1                                                             
3ZGW_A       212 DDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWI 264 human
AAH50520     213 DDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWA 265 zebrafish
NP_001026680 213 DDNVMALYRRITRGKYAVPKWLSPSSTLLLNQLLQVDPKKRITVKHLLSHPWL 265 chicken
CAA78913     213 DDNVMVLYKKIMRGKYEIPKWLSPGSVLLLSQMMQVDPKKRITVKHLLNHPWL 265 African clawed frog
XP_395000    211 DNNIENLYRKILSGKYDEPSWLSSSSKKLIQAMLQIDPKKRITIQELCNHPWI 263 honey bee
XP_781767    233 DDNVSLLYRKILSGVYEEPPWLSVETKELLRHMLQVNPTKRIKMKELIIHPWV 285 purple sea urchin
XP_002613742 212 DDNVGALYRKIRKGQYEIPDWLSPQSVDLINVMLQVNPKLRINVKELLCHPWL 264 Florida lancelet
EFX88933     214 DDNIAILYRKIQSGVYEKPEWLSESSMEMLDQLLQVDPKRRITVAQLLHHPWV 266 common water flea
XP_001636502 214 DDNTYKLYRLIQKGEYEIPSWLSQGTVAILGQLLQVSPRKRAKIQDLVNHDWV 266 starlet sea anemone
CBY32973     212 DDNMPTLYKKIKSGKYDEPEWLSSESKFLLATLLQVDPKKRITMRRLLSHRWL 264 Oikopleura dioica
XP_002115270 208 DDNTVKLYKQILKGEYETPRWLSHGSIKILDSMLQTDPNQRITVKHLLSHPWV 260 Trichoplax adhaerens
NP_001023421 213 DDNMQIMYKKIQSGCFYEPEFLSPLSKQLLRAMLQVVPERRISVKKLLEHDWL 265 nematode
XP_003389642 221 DDNTAELYRLIQNGRYDKPRWLSRDSLEILDVLLQTIPERRVTVDELLNHPWV 273 Amphimedon queenslandica

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