4DN5,4G3F


Conserved Protein Domain Family
STKc_NIK
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cd13991: STKc_NIK 
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Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK)
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Links
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Statistics
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PSSM-Id: 270893
Aligned: 6 rows
Threshold Bit Score: 480.085
Created: 12-Sep-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 27 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1                        #####   #              # #                             #        
4DN5_A        69 YREEVHWATHQ.[2].LGRGSFGEVHRMED.[3].GFQCAVKKVR.[3].FRAEELMACAGL.[1].SPRIVPLYGAVRE 137  human
4G3F_A        53 YREEVHWMTHQ.[2].VGRGSFGEVHRMKD.[3].GFQCAVKKVR.[3].FRVEELVACAGL.[1].SPRIVPLYGAVRE 121  house mouse
NP_001026098 390 YREEVHWTKCH.[2].LGIGSFGEVYKVED.[3].GFQCAAKKVQ.[3].FRAEELTTCAAI.[1].SPKVVPLYGAVKE 458  chicken
CAG02785       9 YKEGREYVLSE.[1].IKDGSYGEVHSAQD.[3].GFKFAVKKIA.[3].FNSEEVGAWSTL.[1].SPRVAELFGVVRE 76   Tetraodon nigroviridis
CAG03027      10 YREGEEYCVLH.[1].IQNGSYGDVFCVRD.[3].GFTCAAKRIP.[3].FGLEEVSTWSVL.[1].SPRVVELFGAVRE 77   Tetraodon nigroviridis
Q99558       393 YREEVHWATHQ.[2].LGRGSFGEVHRMED.[3].GFQCAVKKVR.[3].FRAEELMACAGL.[1].SPRIVPLYGAVRE 461  human


Feature 1                   ####      # ##                                       # # ## #    
4DN5_A       138 GP.[1].VNIFMELL.[2].GSLGQLV.[5].LPEDRALYYLGQALEGLEYLH.[1].RRILHGDVKADNVLLSSD 202  human
4G3F_A       122 GP.[1].VNIFMELL.[2].GSLGQLI.[5].LPEDRALYYLGQALEGLEYLH.[1].RRILHGDVKADNVLLSSD 186  house mouse
NP_001026098 459 GP.[1].VTIFMKLM.[2].GSLGQLI.[5].LPEDRALSYLGQALEGLEYLH.[1].QNILHGDVKAENVLLSDD 523  chicken
CAG02785      77 GP.[1].VLLLMDLK.[1].GSLGQLI.[5].LPEDLGLHYQLQVLTALEYLA.[1].KKVAHLDIKADNVLLSED 140  Tetraodon nigroviridis
CAG03027      78 GP.[1].VVIFMDLK.[1].ACLAQLL.[5].LPEDLALHYLHQTLGALEHLH.[1].RKVLHLDVKVENVLLSAD 141  Tetraodon nigroviridis
Q99558       462 GP.[1].VNIFMELL.[2].GSLGQLV.[5].LPEDRALYYLGQALEGLEYLH.[1].RRILHGDVKADNVLLSSD 526  human


Feature 1                   #  #                          ####                               
4DN5_A       203 .[1].SHAALCDFGHAVCLQPDGLGKD      LLTGDYIPGTETHMAPEVVLG.[3].DAKVDVWSSCCMMLHML 266  human
4G3F_A       187 .[1].SRAALCDFGHALCLQPDGLGKS      LLTGDYIPGTETHMAPEVVMG.[3].DAKVDIWSSCCMMLHML 250  house mouse
NP_001026098 524 .[1].SRALLCDFGHSAHLHPDGLGKC      LVTGNYVPGTETHMAPEVVLG.[3].DSKVDVWSSCCMMLHML 587  chicken
CAG02785     141 .[1].RDTFLCDFGHAERLDNAGQSLS.[22].VFLQPDPKGSETHMAPEIVKG.[3].GAKADVWSSCCMFLHML 226  Tetraodon nigroviridis
CAG03027     142 .[1].RDTFLCDFGLSETVDDSGWSDQ      AFRGGVFPGTETHMAPEVARG.[3].SSKADVWSSCCMLLHML 205  Tetraodon nigroviridis
Q99558       527 .[1].SHAALCDFGHAVCLQPDGLGKS      LLTGDYIPGTETHMAPEVVLG.[3].DAKVDVWSSCCMMLHML 590  human


Feature 1                                                                                        
4DN5_A       267 .[1].GCHPWTQFF.[1].GPLCLKI.[2].EPPPVREIPPSC.[1].PLTAQAIQEGLRKEPIHRVSAAELGGKVNRAL 331  human
4G3F_A       251 .[1].GCHPWTQYF.[1].GPLCLKI.[2].EPPPIREIPPSC.[1].PLTAQAIQEGLRKEPVHRASAMELRRKVGKAL 315  house mouse
NP_001026098 588 .[1].GCHPWTQYY.[1].HPLCLKI.[2].EPPPLREIPPSC.[1].PLTAEIIKMGLEKEPVQRASASELRTKASTAL 652  chicken
CAG02785     227 .[1].GCQPWTRYY.[1].CRLYLKI.[2].DPPPLREIPPDC.[1].HLTFEALKAGLQKDPAKRSSATDLKEKTARAL 291  Tetraodon nigroviridis
CAG03027     206 .[1].GCRPWTRYY.[1].HPLCLQI.[2].EPPPLWEVPSHC.[1].NFTARVFRAGLRKDPERRASARALRRRTTKAL 270  Tetraodon nigroviridis
Q99558       591 .[1].GCHPWTQFF.[1].GPLCLKI.[2].EPPPVREIPPSC.[1].PLTAQAIQEGLRKEPIHRVSAAELGGKVNRAL 655  human


Feature 1             
4DN5_A       332 QQVGG 336  human
4G3F_A       316 QEVGG 320  house mouse
NP_001026098 653 QEVGG 657  chicken
CAG02785     292 KEVGG 296  Tetraodon nigroviridis
CAG03027     271 RAVGG 275  Tetraodon nigroviridis
Q99558       656 QQVGG 660  human

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