Conserved Protein Domain Family
SPRY_PRY_TRIM25-like
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cd13737: SPRY_PRY_TRIM25-like 
PRY/SPRY domain in tripartite motif-containing domain 25 (TRIM25)-like
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of proteins similar to TRIM25 (composed of RING/B-box/coiled-coil core and also known as RBCC proteins). TRIM25 (also called Efp) ubiquitinates the N terminus of the viral RNA receptor retinoic acid-inducible gene-I (RIG-I) in response to viral infection, leading to activation of the RIG-I signaling pathway, thus resulting in type I interferon production to limit viral replication. It has been shown that the influenza A virus targets TRIM25 and disables its antiviral function.
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Statistics
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PSSM-Id: 293972
Aligned: 4 rows
Threshold Bit Score: 343.392
Created: 18-Oct-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

AAI15999      435 LNFDATTASEELFLFKETHSVLNLGI.[6].AGGPFPGFKQWPQVLCSRGLAEGRHYWEADVSN.[2].VCLGVTYRRS 511  cattle
XP_003217315  385 LNFDASTANEELFLFKETHSVLNMGI.[4].YSKPSQGFNHWPQLLCTRSLCEGCHYWEAEISN.[2].LCLGVTYSYR 459  green anole
NP_001028947  444 LNFDPCTASEELFLFKETHSVLNLGI.[6].TNSPLPGFKQWPQVLCCPGLSEGCHYWEAEVSN.[2].MCLGVTYRRS 520  house mouse
EMP30913      786 LNFDPNTASEELLLFKETHSVLNMGI.[4].FFGSCQGFNHWPQVLCTRSLCEGCHYWEVEVSD.[2].VCLGATYSYM 860  green sea turtle


AAI15999      512 .[11].VYLLGRNPYSWCLEWDS.[1].KFSVWHNNTQTVLHG.[2].HRTLGVLLDC.[1].AGCLSFYGVA.[2].VS 582  cattle
XP_003217315  460 .[ 8].FYLIGRNSNSWCLEWDS.[1].KFSVWHDNIQTVVQG.[2].YKTIGVLLNY.[1].AGSLTFYGIS.[2].MN 527  green anole
NP_001028947  521 .[11].VYLLGRNPYSWCLEWDS.[1].KFSVWHNNTQTVLHG.[2].HHTLGVALDF.[1].TGCLSFYSVA.[2].VN 591  house mouse
EMP30913      861 .[ 8].FYLIGRNNTSWCLEWDS.[1].KFSVWHNNIQTVVKG.[2].YKIIGVFLDY.[1].AGSLTFYGVT.[2].MN 928  green sea turtle


AAI15999      583 LLYRFLASF.[1].EPLYPAVMVSS.[1].ASVTLKQ 611  cattle
XP_003217315  528 LIYSFLTTF.[1].EPLYPAAMVSS.[1].ASVTLRQ 556  green anole
NP_001028947  592 LLYRFLTSF.[1].EPLYPAVMVSS.[1].ASLTLKQ 620  house mouse
EMP30913      929 LIYRFLTTF.[1].EPLYPAVMQGE.[2].KPGRPFQ 958  green sea turtle
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