3DP4


Conserved Protein Domain Family
PBP2_iGluR_AMPA_GluR3
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cd13728: PBP2_iGluR_AMPA_GluR3 
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The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR3 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily.
This group contains the ligand-binding domain of the AMPA receptor subunit GluR3, a member of non-NMDA (N-methyl-D-aspartate) type iGluRs which are ligand-gated ion channels that mediate excitatory synaptic transmission in the central nervous system. While this ligand-binding domain is structurally homologous to the periplasmic-binding fold type II superfamily, the N-terminal domain of AMPA receptors belongs to the periplasmic-binding fold type I. The AMPA receptors are the most commonly found receptor in the nervous system and sensitive to the artificial glutamate analog, AMPA. They consist of four types of subunits (GluR1, GluR2, GluR3, and GluR4) which combine to form a tetramer and play an important role in mediating the rapid excitatory synaptic current
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Statistics
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PSSM-Id: 270446
Aligned: 14 rows
Threshold Bit Score: 464.55
Created: 23-Jun-2009
Updated: 2-Oct-2020
Structure
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ligand binding
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Comment:Cyclothiazide (a positive allosteric modulator) binding site based on sequence similarity to other members of the iGluR AMPA family.
  • Structure:3DP4: Rattus norvegicus S1S2 glutamate binding domain of GLuR3 binds glutamate; contacts at 4.0A
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Sequence Alignment
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Feature 1                                                             #                       
3DP4_A     19 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 98  Norway rat
NP_990546 416 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLASEIAKHVGIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 495 chicken
NP_938174 412 NRTIVVTTIMEAPYVMYK.[9].EKYEGYCVDLASEIAKHVGIKYRLSIVM.[3].YGARD.[3].KSWNGMVGELVYGR 491 zebrafish
BAA37124  416 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 495 house mouse
AAI17465  422 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 501 human
P42263    422 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 501 human
AAF61848  422 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 501 human
NP_015564 422 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLAYEIAKHVRIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 501 human
CAA61680  416 NRTIVVTTILESPYVMYK.[9].ERYEGYCVDLASEIAKHVGIKYKLSIVG.[3].YGARD.[3].KIWNGMVGELVYGR 495 chicken
NP_938153 415 NRTIVVTTIMEAPYVMYK.[9].DRYEGYCVDLASEIAKHVGIKYKLSIVA.[3].YGARD.[3].KTWNGMVGELVYGR 494 zebrafish


Feature 1           ###    #                                                  #  ###          
3DP4_A     99 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKGT       PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 167 Norway rat
NP_990546 496 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 689 chicken
NP_938174 492 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[124].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 684 zebrafish
BAA37124  496 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 689 house mouse
AAI17465  502 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 695 human
P42263    502 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 695 human
AAF61848  502 ADIAVAPLTITLVREEVIDFSKPLMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 695 human
NP_015564 502 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 695 human
CAA61680  496 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[125].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 689 chicken
NP_938153 495 ADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQ.[124].PIESAEDLAK.[3].IAYGTLDSGSTKEFFR.[3]. 687 zebrafish


Feature 1                                                 ##  #                             # 
3DP4_A    168 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 237 Norway rat
NP_990546 690 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 759 chicken
NP_938174 685 IAVYEKMWSYMK.[3].PSVFAKTTPDGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 754 zebrafish
BAA37124  690 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 759 house mouse
AAI17465  696 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 765 human
P42263    696 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 765 human
AAF61848  696 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 765 human
NP_015564 696 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 765 human
CAA61680  690 IAVYEKMWSYMK.[3].PSVFTKTTADGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 759 chicken
NP_938153 688 IAVYEKMWSYMK.[3].PSVFVKTTPDGVARVRKS.[3].FAFLLESTMNEYIEQR.[2].CDTMKVG.[2].LDSKGYG 757 zebrafish


Feature 1                                             
3DP4_A    238 VATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 277 Norway rat
NP_990546 760 VATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 799 chicken
NP_938174 755 VATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 794 zebrafish
BAA37124  760 VATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 799 house mouse
AAI17465  766 VATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 805 human
P42263    766 VATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 805 human
AAF61848  766 VATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 805 human
NP_015564 766 VATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGEC 805 human
CAA61680  760 VATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGEC 799 chicken
NP_938153 758 VATPKGSALRTPVSLAVLKLSEQGILDKLKNKWWYDKGEC 797 zebrafish

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