Conserved Protein Domain Family
SPRY_PRY_TRIM16

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cd12890: SPRY_PRY_TRIM16 
PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)
This domain, consisting of the distinct N-terminal PRY subdomain followed by the SPRY subdomain, is found at the C-terminus of TRIM16 and TRIM-like proteins. TRIM16 (also known as estrogen-responsive B box protein or EBBP) does not possess a RING domain like the other TRIM proteins, but contains two B-box domains and can heterodimerize with other TRIM proteins such as TRIM24, Promyelocytic leukemia (PML) protein and Midline-1 (MID1 or TRIM18). It is a regulator of keratinocyte differentiation and a tumor suppressor in retinoid-sensitive neuroblastoma. It has been shown that loss of TRIM16 expression plays an important role in the development of cutaneous squamous cell carcinoma (SCC) and is a determinant of retinoid sensitivity. TRIM16 also has E3 ubiquitin ligase activity.
Statistics
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PSSM-Id: 293948
Aligned: 9 rows
Threshold Bit Score: 353.696
Created: 22-Jun-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

O95361       365 REQFLQYAYDITFDPDTAH.[1].YLRLQEENRKVTNTTPW.[3].YPDLPSRFL.[1].WRQVLSQQSLY.[1].HRYY 430 human
AAI55347     392 RDDFLQYVTPLSLDANTAH.[1].FLRLTEECKKVTNTTPW.[3].YPDLPERFQ.[1].FKQVLTQESFY.[1].GRHY 457 zebrafish
XP_003217131 384 RSDFLKYTCPLTFDPITAH.[1].YLRLLDDNHKVTNTTPW.[3].YPDHLERFE.[1].WRQVLSDKSLY.[1].GRYY 449 green anole
AAH74300     364 RNEFLKYKSNLTLDPVTAH.[1].FLRLLEDNRKVSNTAPW.[3].YPDDPQRFE.[1].FRQVLSAESFY.[1].GRHY 429 African clawed frog
XP_007664696  93 RQEFLKYAYSISFDPDTAH.[1].YLRLLEENRRVTNTTPW.[3].YPDHPDRFE.[1].WRQVLAKQSLY.[1].HRYY 158 platypus
XP_001374088 366 RNDFLKYAYPITFDPDTAH.[1].YLRLQEDNHKVTNTTPW.[3].YPDHPSRFE.[1].LRQVLSKQSLY.[1].NQYY 431 gray short-tailed op...
XP_007260977 350 REDFLKYASPLSFDSSTAH.[1].FLRLTEDGRKVTNTTPW.[3].YPERPERFV.[1].WKQVLASHSFY.[1].GRHY 415 Mexican tetra
Q99PP9       357 RDEFLQYACDITFDPDTAH.[1].YLRLQEDNRKVTNTTPW.[3].YPDLPSRFL.[1].WRQVLSQQSLY.[1].HRYY 422 house mouse
CDQ93947      26 RDDFLKYANPVSFDADTAH.[1].FLRLTEENRKVTNTTPW.[3].YLDVPERFE.[1].WRQVLATESFY.[1].GRHY 91  rainbow trout

O95361       431 FEVEIFG.[1].GTYVGLTCKGIDRKG.[3].NSCISGNNFSWSLQWN.[2].EFTAWYSDM     ETPLKA.[4].RL 495 human
AAI55347     458 FEVDMKG.[1].GTHVGLTYKSIDRKG.[3].NSCIAGNNFSWCLQWN.[2].SFSAWHSDV.[2].PLSCPK.[2].HI 522 zebrafish
XP_003217131 450 FEVEIFG.[1].GIYIGMTNKSIDRKG.[3].NSCISGNNFSWCIKWN.[2].EFSAWHSDM     ETPLKS.[4].RI 514 green anole
AAH74300     430 YEVEFKG.[1].EIYMGLTYKCINRKG.[3].NSCITGNDFSWTLKWN.[2].EFSAWHSDV     ETPLKT.[4].RV 494 African clawed frog
XP_007664696 159 FEVEVSG.[1].GTYVGVTYRSIDRKG.[3].NSCISGNNFSWSLHWG.[2].EFSAWHSDA     ELPLQA.[4].RL 223 platypus
XP_001374088 432 FELEIKG.[1].GVYIGVTNKSIDRKG.[3].NSRISGNNFSWSIHWN.[2].EFSAWHNDS     ETLLKG.[4].RL 496 gray short-tailed op...
XP_007260977 416 FEADISG.[1].GVHVGVTSGCIARQS.[3].NGCLTGHGASWCLQWN.[2].GFSAWNEGQ.[2].PISAPK.[2].RV 480 Mexican tetra
Q99PP9       423 FEVELSG.[1].GTYVGLTCKGIDRKG.[3].NSCISGNSFSWSIHWN.[2].EFTAWHSDT     ETPLKV.[4].RL 487 house mouse
CDQ93947      92 FEVDVSG.[1].GTYVGLTYKSIDRKG.[3].NSCITGNDFSWCLQWN.[2].SFSAWHGDV     ETPLSV.[4].RI 156 rainbow trout

O95361       496 GVYIDF.[1].GGILSFYGVEY.[1].TMTLVHKFACKFSEPVYAAFWL.[3].ENAIRIV 546 human
AAI55347     523 GIYVDY.[1].GGLLAFYDVEN     GMTLIHKYQAEFLEPLYPAFWL.[2].KENVVLL 571 zebrafish
XP_003217131 515 GIYLDY.[1].RGTLSFYGIIS.[1].TMTLLHKFECNFTEPLYPAFWL.[3].ENMMRIV 565 green anole
AAH74300     495 GIYVNY.[1].SGNISFYGVTD     KMTLLHQFDGKFTEPLYAAFWL.[4].SSAVVLS 545 African clawed frog
XP_007664696 224 GVYLNY.[1].GETLSFYGVSS.[1].SMTLLHRFSCKFAEPVFPAFWL.[3].ENSVRIV 274 platypus
XP_001374088 497 GIYLNY.[1].GSTLSFYGIEF.[1].TMVLIHKFNCDFAEPVYPVFWL.[3].ENSIQII 547 gray short-tailed opossum
XP_007260977 481 GVYLDF.[1].QGSLAFYAVDG     GMTLLHRYQAELREPLYPACWL.[3].ENVVMLV 530 Mexican tetra
Q99PP9       488 GIYVNF.[1].GGILSFYGVEY.[1].AMTLIHKFDCKFSEPVYAAFWL.[3].ENAIRIV 538 house mouse
CDQ93947     157 GVYVDY.[1].RGLLAFYGVDD.[2].GMTLIHKYKAEFLEPLYPAFWL.[3].ENVVVLV 208 rainbow trout
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