Conserved Protein Domain Family
SPRY_SOCS3

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cd12876: SPRY_SOCS3 
SPRY domain in the suppressor of cytokine signaling 3 (SOCS3) family
The SPRY domain-containing SOCS box protein family (SPSB1-4, also known as SSB-1 to -4) is composed of a central SPRY protein interaction domain and a C-terminal SOCS box. All four SPSB proteins interact with c-Met, the hepatocyte growth factor receptor, but SOCS3 regulates cellular response to a variety of cytokines such as leukemia inhibitory factor (LIF) and interleukin 6. SOCS3, along with SOCS1, are expressed by immune cells and cells of the central nervous system (CNS) and have the potential to impact immune processes within the CNS. In non-small cell lung cancer (NSCLC), SOCS3 is silenced and proline-rich tyrosine kinase 2 (Pyk2) is over-expressed; it has been suggested that SOCS3 could be an effective way to prevent the progression of NSCLC due to its role in regulating Pyk2 expression.
Statistics
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PSSM-Id: 293936
Aligned: 44 rows
Threshold Bit Score: 213.946
Created: 1-May-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Q6PJ21       104 DWVWD.[ 8].LLSCDNR.[1].VSFHM.[1].YSCGTAAIRGTKELGE     GQHFWEIKMTS.[1].VYGTDMMVGI 168 human
Q9V3U3        64 NWTWS.[ 8].VLRGPNS.[2].VHFHP.[1].WSKGTAGVQGKRSLNN     GRHYWELHVSQ.[1].VFGTSIMFGI 129 fruit fly
EEN59181      12 AWSWE.[12].IGGIKNR.[1].VMFHP.[1].WSRGTVAVRATKPLDK.[1].GVHYWEIRISE.[1].LFGTSMMFGI 81  Florida lancelet
ADY47870      30 YWSWD.[ 9].VLIEDNR     VTFHR.[1].YSYGTAAVRAKKRLTA.[1].TIAYWEIRVPH.[1].LFGTSVMFGI 95  pig roundworm
XP_780661     14 SWGWN.[ 8].QLKGPRN.[2].ALFHP.[1].WSIGAAGVRGTRPLLQ.[1].HCYYWEIAVAP.[1].VYGTSMMVGI 80  purple urchin
XP_002737573  12 NWCWN.[ 9].VFGKRNQ.[1].VLFHP.[1].WSNGTAAVRGNDALNN     GRHYWEIDVSQ.[1].IFGTSMMFGV 77  Saccoglossus kowalev...
XP_009047899  12 AWSWN.[ 8].RIHGKQL.[2].AYFHP.[1].WSNGTAGVRGSKPINI     GRHYWEIKISQ.[1].LFGTSMMFGI 77  owl limpet
EAT32938     106 KWSWS.[ 9].LSGTNNR.[1].VHFHP.[1].WSKGTAGIRGTRVLNN     GRYYWELSVSQ.[1].VFGTSMMFGI 171 yellow fever mosquito
EKC24546      19 RWTWN.[ 8].KTCGEGM.[2].AHFHP.[1].WSNGTAGIRGNCVLNY     GIHYWEIKVSQ.[1].IFGTSMMFGI 84  Pacific oyster
ELU18874      35 EWTWD.[ 8].RLNGARL.[2].ALFHP.[1].WSNGTAGVRGTRSLNR.[1].GAHYWEIHVQR.[1].LFGTSMMFGI 101 Capitella teleta

Q6PJ21       169 GTSDVDL.[9].LLGRDEDSWGLSYTG.[2].HHKGDKTSFSSRF.[1].QGSIIGVHLDT.[2].GTLTFFKNRKCIGV 242 human
Q9V3U3       130 GTKSARL.[7].MLGENEHGWGLSHKG.[2].WHEGVALLYTKRF.[3].QPTQIGVLFDG.[2].GTLTFYKDGKCLGV 203 fruit fly
EEN59181      82 GSAKTRL.[7].VLGENEHSWGLNHRG.[2].WHKGVDRPFTEPF.[3].TTTTVGLLYRR     GTLTYYRDGKCLGE 153 Florida lancelet
ADY47870      96 GNDCARH.[8].MLGADSNSYGLSHTG.[2].FHDGLCVRFCERF.[3].GSTAVGLMFHG.[2].ASLAYFRDGSPLGV 170 pig roundworm
XP_780661     81 GSQKARL.[7].LIGEDNESWGLSHKG.[2].WHGGDSFVFTQPF.[3].ALTIVGVLFDG.[2].GTLTYFKDGELLGQ 154 purple urchin
XP_002737573  78 GTKRARL.[7].LLGENEESWGLSHKG.[2].WNRGESKIYTKPF.[3].EPTTIGILFDG.[2].GTLSYFKDGETLGV 151 Saccoglossus kowalev...
XP_009047899  78 GTKKARL.[7].LLGEDEQSWGLSHKG.[2].WHNGLSRVYTKPF.[3].SSTIIGMLYDG.[2].GTLTYFKDGDCLGV 151 owl limpet
EAT32938     172 GTKKARL.[7].LLGEDKNGWGLSHKG.[2].WHDGMARNYTKRF.[3].QATKIGILFDG.[2].GTLTYYKDDVCLGI 245 yellow fever mosquito
EKC24546      85 GTKRARL.[7].IIGEDQYSWGLSHKG.[2].WHNGKSRQYTKPF.[3].EATVVGVLFDG.[2].GTLTFFKDGFSLGV 158 Pacific oyster
ELU18874     102 ATKKARL.[7].LLGEDEHSWGLSHKG.[2].WHGGRCRPYTRPF.[3].ESTVVGVLYDA.[2].GTLTFYRDGVCLGI 175 Capitella teleta

Q6PJ21       243 AATKL.[4].FYPMVCSTAARSSMKVT.[7].SLQY     LCCHRLR 286 human
Q9V3U3       204 AFRGL.[6].LYPIVCSTAAKTEMTLK.[7].NLQD     RCRAVIM 249 fruit fly
EEN59181     154 AFKGL.[6].LFPMIASTAAKTEMVLG.[7].SLRD     RCRAVIS 199 Florida lancelet
ADY47870     171 AFSHI.[5].LYPMISSTAQKSEFILC.[6].MTPY.[1].LCECALQ 215 pig roundworm
XP_780661    155 ACKDL.[7].LYPIICSTAAKTEMRLV.[7].SLVD     RCRNRIA 201 purple urchin
XP_002737573 152 AFEGF.[6].IFPIISSTAAKTEMTLI.[7].SLQD     RCRAVII 197 Saccoglossus kowalevskii
XP_009047899 152 AFSGL.[6].LYPIVTSTAAKTEMTLG.[7].NLQD     RCRASIL 197 owl limpet
EAT32938     246 AFRGL.[6].LYPIVCSTAAKTEMVLT.[7].NLQD     RCRAIII 291 yellow fever mosquito
EKC24546     159 AFTGL.[6].LYPIAASTAAKTEMTLG.[7].SLQD     RCRVKIL 204 Pacific oyster
ELU18874     176 AFSGL.[6].LYPAVCSTAAKTEMTLG.[7].SLED     RCRSAIA 221 Capitella teleta
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