1WF2,1WF1


Conserved Protein Domain Family
RRM_hnRNPC_like
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cd12341: RRM_hnRNPC_like 
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RNA recognition motif (RRM) found in heterogeneous nuclear ribonucleoprotein C (hnRNP C)-related proteins
This subfamily corresponds to the RRM in the hnRNP C-related protein family, including hnRNP C proteins, Raly, and Raly-like protein (RALYL). hnRNP C proteins, C1 and C2, are produced by a single coding sequence. They are the major constituents of the heterogeneous nuclear RNA (hnRNA) ribonucleoprotein (hnRNP) complex in vertebrates. They bind hnRNA tightly, suggesting a central role in the formation of the ubiquitous hnRNP complex; they are involved in the packaging of the hnRNA in the nucleus and in processing of pre-mRNA such as splicing and 3'-end formation. Raly, also termed autoantigen p542, is an RNA-binding protein that may play a critical role in embryonic development. The biological role of RALYL remains unclear. It shows high sequence homology with hnRNP C proteins and Raly. Members of this family are characterized by an N-terminal RNA recognition motif (RRM), also termed RBD (RNA binding domain) or RNP (ribonucleoprotein domain), and a C-terminal auxiliary domain. The Raly proteins contain a glycine/serine-rich stretch within the C-terminal regions, which is absent in the hnRNP C proteins. Thus, the Raly proteins represent a newly identified class of evolutionarily conserved autoepitopes.
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Statistics
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PSSM-Id: 409778
Aligned: 17 rows
Threshold Bit Score: 109.645
Created: 13-Sep-2011
Updated: 25-Oct-2021
Structure
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Sequence Alignment
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1WF2_A        16 SRVFIGNLNT.[2].VKKSDVEAIFS.[1].YGKIVGCSVH.[1].GFAFVQYVN.[2].NARAAVAGE.[1].GRMIAG 77  human
1WF1_A        28 SRVFIGNLNT.[2].VKKSDVETIFS.[1].YGRVAGCSVH.[1].GYAFVQYSN.[2].HARAAVLGE.[1].GRVLAG 89  human
AAX28497      18 SRVFVGNLNT.[2].MSKTELESIFS.[1].YGAVVGISVH.[1].GYAFIQYAN.[2].NARAAVIGE.[1].SKTYYN 79  Schistosoma japonicum
NP_996010     20 SRIFVGNLNT.[2].CSKTDVERMFQ.[1].YGRLAGISMH.[1].GYAFVQFTN.[2].DARNACHGE.[1].GKTVLS 81  fruit fly
Q86SE5        21 SRVFIGNLNT.[2].VKKVDIEAIFS.[1].YGKIVGCSVH.[1].GYAFVQYMS.[2].HARAAVAGE.[1].ARVIAG 82  rhesus monkey
XP_002399808  41 SRIFVGNLNT.[2].VSKEDVERLFK.[1].YGRIIGISMH.[1].GYAFVQYTD.[2].DARNAVLGE.[1].GRTIAG 102 black-legged tick
XP_780427     39 SRVFVGNLNP.[3].TDRMQLYHIFL.[1].YGNVKAISLH.[1].GFAFVQYDT.[2].EARTAVAEE.[1].GNLFGT 101 purple urchin
EEN50078      37 ARVFIGNLPT.[2].MTRQELEDQFS.[1].YGRVTACSLH.[1].GFGFVQFAE.[2].DARESVKGE.[1].GKVIKG 98  Florida lancelet
XP_001628761  18 CRIFIGNLAT.[2].IARQDLEEIFS.[1].HGKVLGCSLH.[1].NFGFVQFET.[2].GADEAVAKE.[1].GRIING 79  starlet sea anemone
XP_007910446  35 RRIFVGNLPT.[2].MVRKDLEDIFL.[1].YGKINALSIH.[1].GFGFVQFDR.[2].DAKASVQGE.[1].GRMCRG 96  elephant shark


1WF2_A        78 QVLDIN 83  human
1WF1_A        90 QTLDIN 95  human
AAX28497      80 MVLDVT 85  Schistosoma japonicum
NP_996010     82 QTLDVN 87  fruit fly
Q86SE5        83 QPLDIN 88  rhesus monkey
XP_002399808 103 QILGGL 108 black-legged tick
XP_780427    102 QKLDLC 107 purple urchin
EEN50078      99 FKVDIK 104 Florida lancelet
XP_001628761  80 KKIGML 85  starlet sea anemone
XP_007910446  97 YRLDVN 102 elephant shark
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