Conserved Protein Domain Family
RRM_NOL8

?
cd12226: RRM_NOL8 
RNA recognition motif (RRM) found in nucleolar protein 8 (NOL8) and similar proteins
This model corresponds to the RRM of NOL8 (also termed Nop132) encoded by a novel NOL8 gene that is up-regulated in the majority of diffuse-type, but not intestinal-type, gastric cancers. Thus, NOL8 may be a good molecular target for treatment of diffuse-type gastric cancer. Also, NOL8 is a phosphorylated protein that contains an N-terminal RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), suggesting NOL8 is likely to function as a novel RNA-binding protein. It may be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells.
Statistics
?
PSSM-Id: 409673
Aligned: 23 rows
Threshold Bit Score: 83.3948
Created: 18-Nov-2011
Updated: 25-Oct-2021
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:

Q76FK4          9 RLYVGGL.[5].EADLQNQFSRFG.[3].DVEIITR.[ 8].KVFAYINIS.[4].DLKKCMSVLN.[1].TKWKGGTLQ 83   human
Q9HFE6          6 RIYVGGL.[5].SSDLESRFSRFG.[3].NLEIINK.[ 7].QRFAYLNFR.[4].KWQKCKSYLS.[1].ATFKGSKLR 79   fission yeast
XP_002175698    9 RVFIGGL.[5].EEDLVPRLQRFG.[3].NFEIVEK.[ 7].HRFAYVDLE.[4].NWVKCRTQLT.[1].VVFRGSRLK 82   Schizosaccharomyce...
CAL52065       22 RLFVGGL.[5].AADLRRRFAPFG.[3].CVDLILD.[10].RGFAFVELR.[5].KLGRCISTLN.[1].CTWRGREMV 99   Ostreococcus tauri
EFN59108        3 RLFVGGL.[5].PDDLRQRFLPFG.[3].ECSIAPA.[10].RNFGHVELQ.[5].ALRKCIAAYN.[1].CKWRGSQLK 80   Chlorella variabilis
Q08287          8 RIFVGNI.[7].YSELLDRFGKFG.[3].DFQFEKH      NHFAFIDIR.[5].DFNKLRKSFN.[1].VKFKGNILK 77   Saccharomyces cere...
CCE78764       10 RIHIGNI.[7].TSLLTRRISKFG.[4].DIELHTK.[ 4].HYFGYLTLR.[4].DLGKLKAALS.[1].SVFMGGRLT 83   Millerozyma farino...
XP_445030       5 RLFIGNL.[7].LADLEQRFKAFG.[6].QDVFERH      NGFAFVTMR.[5].ALQRLKSRFH.[1].VKFKGNQLI 77   Candida glabrata C...
XP_002493278    7 RIYIGNI.[7].IGNLETRLKRYG.[4].PLELHKK.[ 4].SYFAYISLK.[4].NFAKLKGSLN.[1].LNYKGSRVV 80   Pichia pastoris GS115
XP_500104       2 RLHISNL.[7].SSDLVKRLNRFG.[4].ELEVRQK.[ 4].TAYGFIDID.[4].QLGQLKKALN.[1].VRYKGNVIG 75   Yarrowia lipolytic...

Q76FK4         84 IQLAK 88   human
Q9HFE6         80 IEEAR 84   fission yeast
XP_002175698   83 LEEAK 87   Schizosaccharomyces japonicus yFS275
CAL52065      100 VARAQ 104  Ostreococcus tauri
EFN59108       81 CAPAH 85   Chlorella variabilis
Q08287         78 VDEAK 82   Saccharomyces cerevisiae S288c
CCE78764       84 ISQAK 88   Millerozyma farinosa CBS 7064
XP_445030      78 VDYAR 82   Candida glabrata CBS 138
XP_002493278   81 VDMAR 85   Pichia pastoris GS115
XP_500104      76 ISQAK 80   Yarrowia lipolytica CLIB122
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap