Conserved Protein Domain Family
SH3_GAS7
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cd11829: SH3_GAS7 
Src homology 3 domain of Growth Arrest Specific protein 7
GAS7 is mainly expressed in the brain and is required for neurite outgrowth. It may also play a role in the protection and migration of embryonic stem cells. Treatment-related acute myeloid leukemia (AML) has been reported resulting from mixed-lineage leukemia (MLL)-GAS7 translocations as a complication of primary cancer treatment. GAS7 contains an N-terminal SH3 domain, followed by a WW domain, and a central F-BAR domain. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
Links
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Statistics
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PSSM-Id: 212763
Aligned: 6 rows
Threshold Bit Score: 105.673
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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peptide ligand
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1              # #  #    #                 ##                 # ## 
O60861          5 RCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKE.[1].GLRGWFPASYV 57   human
NP_001090555    5 LCRTLYAFTGDQHQQGLKFEAGEVIKVLQFLDGGWWEGEKD     GMRGWFPASYV 56   African clawed frog
XP_415577       5 RCQTLYPFSGERHRQGLRFAAGELITVLQVPDGGWWEGQKE.[1].GLRGWFPASYV 57   chicken
CAG02584     1188 DLAETQVNNGEQHQQGLSFDAGEIIRVVQALPGGWWEGERD     GHRGWFPTSYV 1239 spotted green pufferfish
XP_002606095    7 LCRALYDFVPEPGEQGLAFEAGDWVRVLQTAEDGWWEGEKD.[1].GVRGWFPATYV 59   Florida lancelet
XP_003199593    5 FCRSLYAFTGEQHREGLSFQPGELILITQAPEGGWWEGEKD     GARGWFPSTYV 56   zebrafish

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