2YUO


Conserved Protein Domain Family
SH3_SGSM3
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cd11813: SH3_SGSM3 
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Src Homology 3 domain of Small G protein Signaling Modulator 3
SGSM3 is also called Merlin-associated protein (MAP), RUN and SH3 domain-containing protein (RUSC3), RUN and TBC1 domain-containing protein 3 (RUTBC3), Rab GTPase-activating protein 5 (RabGAP5), or Rab GAP-like protein (RabGAPLP). It is expressed ubiquitously and functions as a regulator of small G protein RAP- and RAB-mediated neuronal signaling. It is involved in modulating NGF-mediated neurite outgrowth and differentiation. It also interacts with the tumor suppressor merlin and may play a role in the merlin-associated suppression of cell growth. SGSM3 contains TBC, SH3, and RUN domains. SH3 domains are protein interaction domains that bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs. They play versatile and diverse roles in the cell including the regulation of enzymes, changing the subcellular localization of signaling pathway components, and mediating the formation of multiprotein complex assemblies.
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Statistics
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PSSM-Id: 212747
Aligned: 13 rows
Threshold Bit Score: 112.207
Created: 31-May-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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peptide ligand
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:peptide ligand binding site [polypeptide binding site]
Evidence:
  • Comment:based on the binding of peptide ligands to the SH3 domains of other superfamily members
  • Comment:SH3 domains typically bind proline-rich ligands, preferentially to PxxP motifs.
  • Citation:PMID 7664083
  • Citation:PMID 7735837
  • Comment:flanking hinge and loops (RT and n-Src) confer sequence specificity for ligand residues outside the core binding motif
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1             # #  #   #                     ##            # ##   
2YUO_A         9 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVEV 61  house mouse
Q7T2D0       488 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVEI 540 zebrafish
A6H8I2       486 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVDI 538 African clawed frog
NP_650432    540 RAKALHDFERHDDDELGFRRNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVEL 592 fruit fly
XP_001627121 465 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVQI 517 starlet sea anemone
XP_001203600 134 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVEI 186 purple urchin
XP_002595687 478 RAKALLDFERHDDDELGFRKNDIITIISQ.[1].DEHCWVGELNGLRGWFPAKFVEL 530 Florida lancelet
XP_002110079 478 RARAILDFDGHDDNELGFRKNDIITIISQ.[1].DDHCWVGELNGLKGWFPAKFVEL 530 Trichoplax adhaerens
XP_002399358 489 RAKALLNFERHDDDELGFRKNDIITIISQ.[1].DEHCWIGELNGLRGWFPAKFVDL 541 black-legged tick
XP_002124002 476 RGKALLNFERNDDDELGFRKNDIITIISM.[1].DEHCWVGELNGLQGWFPAKFVEL 528 Ciona intestinalis
NP_509421    528 RARALLDFAREEENELGFRKNDIVTIISE.[1].DEHCWVGEVNGLRGWFPAKFVEV 580 nematode
XP_002573587 480 RAKALIDFERFEVDELQFHKNDILTIINS.[1].DEHCWIGELNDQQGWFPAKFVEL 532 Schistosoma mansoni
EFX88003     544 RAKALLDFERHDDDELGFRKNDVITVISQ.[1].DEDCWIGELNGLRGWFPAKFVQL 596 common water flea

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