Conserved Protein Domain Family
HDAC6-dom1

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cd11682: HDAC6-dom1 
Histone deacetylase 6, domain 1
Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).
Statistics
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PSSM-Id: 212545
Aligned: 5 rows
Threshold Bit Score: 655.383
Created: 21-Feb-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activeZn binding site
Feature 1:putative active site [active site]
Evidence:
  • Comment:Active center contains inhibitor and a catalytic Zn ion that coordinates side chain atoms of two aspartates and one histidine, and a water molecule.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:

Feature 1                                                                                         
Q9UBN7         99 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQ.[1].RFAEKEELMLVHSLEYIDLMETTQYMNEGELR.[1].LADT 170  human
XP_001493915   99 CLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQ.[1].RFAEKEELMLVHSLEYIDLMETTQYMNERELR.[1].LADT 170  horse
NP_001080486   94 CLWDENFPECPGRIWAVRDKMAEYGLAERCVAVP.[1].REASEEEILLIHSPQYVALMRSTQKMTMDELR.[1].LSDR 165  African clawed frog
XP_003216905  136 CPWDESFPECPERLVAIRDKLLQCGLLERCVPVL.[1].REISEEEILLAHSPEYLALMKSTETMSKAELK.[1].LSDT 207  green anole
XP_693858      76 CLWDASHPECPARVSTVMEMLETEGLLGRCVQVE.[1].RAVTEDELLLVHTKEYVELMKSTQNMTEEELK.[1].LAEK 147  zebrafish

Feature 1                                                      ##          ##                     
Q9UBN7        171 YDSVYLHPNSYSCACLASGSVLRLVDAV.[4].IRNGMAIIRPPGHHAQH.[2].MDGYCMFNHVAVAARYA.[7].RVL 248  human
XP_001493915  171 YDSVYLHPNSYTCACLASGSVLRLVDAV.[4].IRNGMAIIRPPGHHAQH.[2].MDGYCMFNHVAVAARYA.[7].RIL 248  horse
NP_001080486  166 YDSVYLHPTSFTCASLAVGSVLQLVDRV.[4].IRNGLAVVRPPGHHAHT.[2].MNGYCMFNQLAIAARYA.[7].RVL 243  African clawed frog
XP_003216905  208 FDSVYLHPNSYHCACLAAGSVLQVVEKV.[4].LCNGLAVVRPPGHHAQH.[2].MDGYCMFNNVGIAAQYA.[7].RVL 285  green anole
XP_693858     148 YDSVYLHPGFFSSACLSVGSVLQLVDKV.[4].LRNGFSINRPPGHHAQA.[2].MNGFCMFNNLAIAARYA.[7].RVL 225  zebrafish

Feature 1             # #                                                                         
Q9UBN7        249 IVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWST.[1].GFGQGQGYTINVPWNQVGM.[1].DADYI 320  human
XP_001493915  249 IVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASDWST.[1].GFGQGRGYTINVPWNQVGM.[1].DADYI 320  horse
NP_001080486  244 IVDWDVHHGQGTQFIFESDPSVLYFSVHRYDNGGFWPHLKESASSA.[1].GKERGERFNVNVAWNKTRM.[1].DADYI 315  African clawed frog
XP_003216905  286 IVDWDVHHGQGTQYLFEDNPSVCYFSIHRYEGGNFWPHLPESDSHA.[1].GRGRGEGYNINVPWDQIGM.[1].DADYL 357  green anole
XP_693858     226 IVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSS.[1].GSGAGQGYNINLPWNKVGM.[1].SGDYI 297  zebrafish

Feature 1                                  #                                     #                
Q9UBN7        321 AAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGY.[3].ALAEGVSAS 398  human
XP_001493915  321 AAFLHILLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAHLTHLLMGLAGGKLILSLEGGY.[3].SLAEGVSAS 398  horse
NP_001080486  316 HVFLNVLLPVAYEFQPHLVLVAAGFDSVVGDPKGEMSATPACFSHLTHLLMSLAQGRLILSLEGGY.[3].SLAEGACAS 393  African clawed frog
XP_003216905  358 AAFLHILMPVALEFQPQLVLVAAGFDSVIGDPKGEMATTPGCFAHLAHLLMPLSGGKLVLSLEGGY.[3].SLAEGTCTV 435  green anole
XP_693858     298 TAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQGRLVLALEGGY.[3].STAEGVCAS 375  zebrafish

Feature 1                                             
Q9UBN7        399 LHTLLGDPCP.[6].APCRSAQASVSCALEALEPFW 435  human
XP_001493915  399 LHTLLGDPCP.[6].APCLSAKASLSCTLEALEPFW 435  horse
NP_001080486  394 LKALLGDPCP.[6].APCQSALDSMSDTISAHCSLW 430  African clawed frog
XP_003216905  436 LKALLGDPCP.[6].APCRSALHSVSQTIAAHSKFW 472  green anole
XP_693858     376 MRSLLGDPCP.[6].APCESALKSISKTISDLYPFW 412  zebrafish

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