Conserved Protein Domain Family
Deadenylase_CCR4a
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cd10313: Deadenylase_CCR4a 
C-terminal deadenylase domain of CCR4a, also known as CCR4-NOT transcription complex subunit 6
This subfamily contains the C-terminal catalytic domain of the deadenylase, CCR4a, also known as CCR4-NOT transcription complex subunit 6 (CNOT6). CCR4 belongs to the large EEP (exonuclease/endonuclease/phosphatase) superfamily that contains functionally diverse enzymes that share a common catalytic mechanism of cleaving phosphodiester bonds. CCR4 is the major deadenylase subunit of the CCR4-NOT transcription complex, which contains two deadenylase subunits and several noncatalytic subunits. The other deadenylase subunit, Caf1, is a DEDD-type protein and does not belong in this superfamily. There are two vertebrate CCR4 proteins, CCR4a and CCR4b (also called CNOT6-like or CNOT6L). CCR4a associates with other components, such as CNOT1-3 and Caf1, to form a CCR4-NOT multisubunit complex, which regulates transcription and mRNA degradation. The nuclease domain of CCR4a exhibits Mg2+-dependent deadenylase activity with specificity for poly (A) RNA as substrate. CCR4a is a component of P-bodies and is necessary for foci formation of various P-body components. It also plays a role in cellular responses to DNA damage, by regulating Chk2 activity.
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Statistics
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PSSM-Id: 197340
Aligned: 4 rows
Threshold Bit Score: 737.625
Created: 24-May-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Feature 1:putative catalytic site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 

Feature 1            #                                               #                           
Q9ULM6       191 VMCYNVLCDKYAT.[2].LYGYCPSWALNWDYRKKAIIQEILSCNADIVSLQEVE.[1].EQYYSFFLVEL.[3].GYNG 261 human
NP_001103498 191 VMCYNVLCDKYAT.[2].LYGYCPSWALNWSYRKKSIMQEILNCNADIISLQEVE.[1].EQYFDFFLLEL.[3].GYDG 261 zebrafish
AAH91632     186 VMCYNVLCDKYAT.[2].LYGYCPSWALNWDYRKKAIIQEILSCNADIISLQEVE.[1].EQYYSFFLVEL.[3].GYNG 256 African clawed frog
XP_414612    197 VMCYNVLCDKYAT.[2].LYGYCPSWALNWEYRKKAIMQEILSCNADIISLQEVE.[1].EQYYSFFLVEL.[3].GYNG 267 chicken


Feature 1                                                                                      
Q9ULM6       262 FFSPKS.[2].RTMSEQER.[2].VDGCAIFFKT.[1].KFTLVQKHTVEF.[13].MLNRV.[2].KDNIGVAVLLE 333 human
NP_001103498 262 FFSPKS.[2].RTMSESDR.[2].VDGCAIFYKT.[1].KFNVVQKHTVEF.[13].MLNRV.[2].KDNIGVAVLLE 333 zebrafish
AAH91632     257 FFSPKS.[2].RTMSEQER.[2].VDGCAIFFKT.[1].KFTLVQKHTVEF.[13].MLNRV.[2].KDNIGVAVLLE 328 African clawed frog
XP_414612    268 FFSPKS.[2].RTMSEQER.[2].VDGCAIFFKT.[1].KFTLVQKHTVEF.[13].MLNRV.[2].KDNIGVAVLLE 339 chicken


Feature 1                    #                                     # #                         
Q9ULM6       334 .[21].ILVANAHMHWDPEYSDVKLVQTMMFLSEVKN.[19].IPLVLCADLNSLPDSGVVEYLSTG.[5].HKDFKE 439 human
NP_001103498 334 .[21].LLVANAHMHWDPEYSDVKLVQTMMFLSEVKN.[20].IPLVLCADLNSLPDSGVVEYLSTG.[5].HKDFKE 440 zebrafish
AAH91632     329 .[21].ILVANAHMHWDPEYSDVKLVQTMMFLSEVKN.[19].IPLVLCADLNSLPDSGVVEYLSTG.[5].HKDFKE 434 African clawed frog
XP_414612    340 .[21].VLVANAHMHWDPDYSDVKLVQTMMFLSEVKN.[19].IPLVLCADLNSLPDSGVVEYLSTG.[5].HKDFKE 445 chicken


Feature 1                                        #                                      ##       
Q9ULM6       440 .[24].HGFKLQSAY.[6].YTNYTFDFKGIIDYIFY.[3].QLNTLGILGPLD.[7].NISGCPHPLIPSDHFSLFAQL 538 human
NP_001103498 441 .[24].HAFKLKSAY.[6].YTNYTFDFRGVIDYIFY.[3].QLNVLGVLGPLD.[7].NISGCPHPLIPSDHFSLFAQL 539 zebrafish
AAH91632     435 .[24].HGFKLKSAY.[6].YTNYTFDFKGIIDYIFY.[3].QLNTLAILGPLD.[7].NISGCPHPLIPSDHFSLFAQL 533 African clawed frog
XP_414612    446 .[24].HGFKLKSAY.[6].YTNYTFDFKGIIDYIFY.[3].QLNILGILGPLD.[7].NISGCPHPLIPSDHFSLFAQL 544 chicken


Feature 1          
Q9ULM6       539 EL 540 human
NP_001103498 540 EL 541 zebrafish
AAH91632     534 EL 535 African clawed frog
XP_414612    545 EL 546 chicken

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